Ophiopogonin D Cas No.945619-74-9
Ophiopogon Saponin D Namme
Ingelske namme:(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl-6-deoksy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoksy-β-D-galactopyranoside
Bioaktiviteit fan Ophiopogon Japonicus Saponin D
Beskriuwing:Ophiopogon D is in seldsum natuerlik C29 steroidale glycoside isolearre út 'e knol fan Ophiopogon japonicus.Ophiopogonin D is in CYP2J3-inducer dy't CYP2J2 / eets en PPAR yn minsklike umbilical vein endothelial sellen (HUVEC's) fergruttet α De ekspresje fan Ang II ynhibearre signifikant Ang II-induzearre NF- κB nukleêre translokaasje, I κ B α Ca Down-regulaasje, intracellular overload en aktivearring fan proinflammatory cytokines.Ophiopogonin D is al tûzenen jierren brûkt om ûntstekkingen en kardiovaskulêre sykten te behanneljen.
Relevante kategoryen
Sinjaalpaad >> transmembrane ferfier >> kalsiumkanaal
Undersyksfjild >> kardiovaskulêre sykte
Sinjaalpaad >> selsyklus / DNA-skea >> PPAR
Undersyksfjild >> ûntstekking / ymmuniteit
Doel
PPARα
NF-KB
Ca2+
Referinsjedokuminten:[1].Wang L, et al.Homo-aro-cholestane, furostane en spirostane saponins út de knollen fan Ophiopogonjaponicus.Fytokemy.Apr 2017;136:125-132.
[2].Huang X, et al.Ophiopogonin D en EET's ferbetterje Ang II-induzearre inflammatoare antwurden fia aktivearjen fan PPARα yn HUVEC's.Biochem Biophys Res Commun.2017 Aug 19;490(2):123-133.
Ingelske alias fan Ophiopogon saponin D
(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl-6-deoksy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoksy-β-D-galactopyranoside β-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl O-6-deoksy-α-L-mannopyranosyl-(1- >2)-O-[β-D-xylopyranosyl-(1->3)]-6-deoksy-
(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-hydroxy-2-(((4R,5'R,6R,6aR,6bS,8aS) ,8bR,9S,10R,11aS,12aS,12bS)-4-hydroxy-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a, 6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[nafto[2',1':4,5]indeno[2,1-b]furan-10,2 '-pyran]-6-yl)oksy)-6-methyl-4-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oksy)tetrahydro- 2H-pyran-3-yl)oksy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
Ophiopogonin D
Deacetylophiopogonin C
