Salvianolic acid B / Lithospermic acid B Lithospermate-B CAS No.115939-25-8
Bayani mai mahimmanci
Salvianolic acid B shine narkar da kwayoyin Danshensu guda uku da kwayar caffeic acid guda daya.Yana daya daga cikin mafi yawan binciken salvianolic acid.Yana da mahimmancin tasirin magunguna akan zuciya, kwakwalwa, hanta, koda da sauran gabobin.Wannan samfurin yana da tasirin haɓaka zagayawa na jini da cire ƙwaƙƙwaran jini, cire meridians da kunna haɗin gwiwa.Ana amfani da shi musamman don maganin bugun jini wanda ke haifar da stasis na jini yana toshe meridians, irin su numbness na rabin jiki da gaɓoɓi, rauni, ciwon kwangila, gazawar mota, karkatar da baki da ido, da sauransu.
Laƙabi:salvianolic acid B, salvianolic acid, salvianolic acid B
Sunan Ingilishi:salvianolic acid B
Tsarin kwayoyin halitta:c36h30o16
Nauyin kwayoyin halitta:718.62
Lambar CAS:115939-25-8
Hanyar ganowa:HPLC ≥ 98%
Ƙayyadaddun bayanai:10mg, 20mg, 100mg, 500mg, 1g (ana iya kunshe bisa ga abokin ciniki bukatun)
Aiki da amfani:Ana amfani da wannan samfurin don tantance abun ciki.
Jiki da sinadarai Properties
Kaddarori:samfurin shine farin foda.
Dandanan ɗanɗano ɗan ɗaci ne da astringent, tare da haɓakar danshi.Mai narkewa a cikin ruwa, ethanol da methanol.
Salvianolic acid B an kafa ta ta hanyar haɗakar da kwayoyin salvianolic acid guda 3 da kuma kwayoyin 1 na caffeic acid.Yana da ƙungiyoyin carboxyl guda biyu kuma yana wanzuwa a cikin nau'ikan gishiri daban-daban (K +, Ca2 +, Na +, NH4 +, da sauransu).A cikin aiwatar da Decoction da maida hankali, karamin sashi na salvianolic acid B yana hydrolyzed zuwa purple oxalic acid da salvianolic acid, kuma wani ɓangare na salvianolic acid B ya zama rosmarinic acid a ƙarƙashin yanayin acidic;Salvianolic acid A da C na iya zama tautomeric a cikin bayani.
Ƙayyadaddun bayanai
5%, 10%, 50%, 70%, 90%, 98%
Tsarin Hakar
Radix Salviae Miltiorrhizae an murkushe shi, an saka shi a cikin tankin hakar, an jika shi da adadin 0.01mol/l hydrochloric acid sau 8 a cikin dare, sa'an nan kuma an shafe shi da adadin ruwa sau 14.Maganin da aka cirewa yana tsarkake shi ta AB-8 macroporous resin ginshiƙi.Da fari dai, zazzage da 0.01mol/l hydrochloric acid don cire ƙazantattun abubuwan da ba a haɗa su ba, sa'an nan kuma ƙara da 25% ethanol don cire ƙazantattun ƙazantattun igiyoyi.A ƙarshe, tattara 40% ethanol eluent a ƙarƙashin rage matsa lamba don dawo da ethanol da daskare-bushe don samun jimlar Salvia miltiorrhiza phenolic acid tare da tsafta fiye da 80%.
Gane
Ɗauki 1g na samfurin, sai a niƙa shi, ƙara 5ml na ethanol, juzu'i sosai, tace, ɗimbin digo na tacewa, dige shi a kan takardar tacewa, bushe shi, kiyaye shi a ƙarƙashin fitilar ultraviolet (365nm), nuna blue- launin toka mai launin toka, rataya takardar tacewa a cikin kwalban maganin ammonia mai da hankali (ba tuntuɓar ruwa ba), fitar da shi bayan mintuna 20, kiyaye shi a ƙarƙashin fitilar ultraviolet (365nm), yana nuna haske mai shuɗi-kore.
Acidity:Ɗauki maganin ruwa mai ruwa a ƙarƙashin abin tsabta, kuma ƙimar pH za ta zama 2.0 ~ 4.0 (shafi na 1977 na Pharmacopoeia na Sinanci).
Ƙaddamar da abun ciki
An ƙaddara shi ta babban aikin chromatography na ruwa (Shafi VI D, Juzu'i na I, Pharmacopoeia na Sinanci, EDITION 2000).
Octadecyl silane bonded silica gel da aka yi amfani da matsayin filler a cikin chromatographic yanayi da tsarin aikace-aikace gwajin;Methanol acetonitrile formic acid ruwa (30:10:1:59) shine tsarin wayar hannu;Tsayin da aka gano shine 286 nm.Adadin faranti da aka lissafta bisa ga salvianolic acid B kololuwa ba zai zama ƙasa da 2000 ba.
Shirye-shiryen bayani daidai auna daidai adadin maganin salvianolic acid B da kuma ƙara ruwa don sanya shi dauke da 10% a kowace 1ml μG bayani.
Shirye-shiryen maganin gwajin ɗaukar kimanin 0.2g na samfurin, auna shi daidai, saka shi a cikin kwalban aunawa na 50ml, ƙara adadin methanol mai dacewa, sonicate na minti 20, kwantar da shi, ƙara ruwa zuwa sikelin, girgiza shi da kyau, tace. shi, daidai gwargwado 1ml na ci gaba da tacewa, sanya shi a cikin kwalban auna 25ml, ƙara ruwa zuwa ma'aunin, girgiza shi da kyau.
Hanyar ƙaddara daidai tana ɗaukar 20% na maganin sarrafawa da 20% na maganin gwajin μ l.Zuba shi a cikin chromatograph na ruwa don ƙaddara.
Tasirin Magunguna
Salvianolic acid B shine narkar da kwayoyin Danshensu guda uku da kwayar caffeic acid guda daya.Yana daya daga cikin mafi yawan binciken salvianolic acid.Yana da mahimmancin tasirin magunguna akan zuciya, kwakwalwa, hanta, koda da sauran gabobin.
Antioxidant
Salvianolic acid B yana da tasirin antioxidant mai ƙarfi.Gwaje-gwaje a cikin vivo da in vitro sun nuna cewa salvianolic acid B na iya lalata iskar oxygen kyauta kuma ya hana peroxidation lipid.Ƙarfin aikin sa ya fi na bitamin C, bitamin E da mannitol.Yana daya daga cikin sanannun samfuran halitta tare da tasirin maganin antioxidant mafi ƙarfi Nazarin Pharmacological ya nuna cewa salvianolic acid don allura yana da tasirin antioxidant na zahiri, yana hana haɓakar platelet da thrombosis, kuma yana iya tsawaita lokacin rayuwar dabbobi a ƙarƙashin hypoxia.Sakamakon ya nuna cewa salvianolic acid don allura (60 ~ 15mg / kg) na iya inganta haɓakar ƙarancin ƙwayar cuta a cikin berayen tare da rauni na ischemia-reperfusion na cerebral, inganta haɓakar halayen halayen kuma yana rage girman yanki na infarction na cerebral.Akwai babban bambanci tsakanin manya da matsakaici (60 da 30mg / kg);Salvianolic acid don allura na iya inganta haɓakar ƙwayar cuta ta hanyar FeCl3 da ke haifar da ischemia na cerebral a cikin berayen a cikin 1, 2 da 24 hours bayan gudanarwa, wanda ya bayyana a cikin inganta yanayin rashin lafiya da kuma rage ƙwayar ƙwayar cuta;Salvianolic acid 40 mg / kg don allura yana hana haɓakar platelet ɗin zomo wanda ADP, arachidonic acid da collagen suka haifar, kuma ƙimar hanawa ya kasance 81.5%, 76.7% da 68.9% bi da bi.Salvianolic acid 60 da 30mg / kg don allura yana hana thrombosis a cikin berayen;Salvianolic acid 60 da 30mg / kg don allura yana daɗaɗa lokacin rayuwa na beraye a ƙarƙashin hypoxia.
Aikace-aikacen asibiti
Wannan samfurin yana da tasirin haɓaka zagayawa na jini da cire ƙwaƙƙwaran jini, cire meridians da kunna haɗin gwiwa.Ana amfani da shi musamman don maganin bugun jini wanda ke haifar da stasis na jini yana toshe meridians, irin su numbness na rabin jiki da gaɓoɓi, rauni, ciwon kwangila, gazawar mota, karkatar da baki da ido, da sauransu.
Store
A wuri mai sanyi da bushewa.
Wa'adin Tabbatarwa
Shekaru biyu.
Hanyar Ajiya
2-8 ° C, adana a cikin sanyi da bushe wuri kuma nesa da haske.
Abubuwan Bukatar Kulawa
Ya kamata a adana samfurin a ƙananan zafin jiki.Idan an fallasa shi zuwa iska na dogon lokaci, za a rage abun ciki.
