Hyperoside；Hypercin Cas No. 482-36-0
ʻIke lāʻau lapaʻau
[inoa huahana] hypericin
[Inoa Pelekane] Hyperoside
[alias] hyperin, quercetin 3-galactoside, quercetin-3-o-galactoside
[kumu molekula] c21h20o12
[kaumaha molekula] 464.3763
[C like No.] 482-36-0
[ka hoʻokaʻawale kemika] flavonoids
[kumu] Hypericum perforatum L
[Hōʻike] > 98%
[Safety terminology] 1. Mai hanu i ka lepo.2. Inā pilikia a pilikia paha, e ʻimi koke i ka lāʻau lapaʻau (e hōʻike i kona lepili inā hiki).
[Pharmacological efficacy] Hoʻolaha nui ʻia ka Hypericin.He huahana kūlohelohe koʻikoʻi me nā ʻano hana physiological like ʻole, e like me anti-inflammatory, antispasmodic, diuretic, cough relieving, blood pressure reducing, cholesterol lowering, protein assimilation, local and central analgesia, a me nā hopena pale i ka naʻau a me nā moku cerebral.
[Nā waiwai kino a me kemika] Crystal acicular melemele māmā.ʻO ka helu hoʻoheheʻe he 227 ~ 229 ℃, a ʻo ka rotation optical - 83 ° (C = 0.2, pyridine).Hiki ke hoʻoheheʻe ʻia i ka ethanol, methanol, acetone a me pyridine a paʻa ma lalo o nā kūlana maʻamau.Hoʻopili ʻo ia me ka waika hydrochloric magnesium pauka e hana i ka ʻulaʻula cherry, a ʻo ka ferric chloride ka ʻōmaʻomaʻo, α- Naphthol pane maikaʻi.
[Risk terminology] Poino ke aleia.
Hana lāʻau lapaʻau
1. He hopena analgesic koʻikoʻi ka Hypericin, ʻoi aku ka nāwaliwali ma mua o ka morphine, ʻoi aku ka ikaika ma mua o ka aspirin, a ʻaʻohe ona hilinaʻi.ʻO Hypericin kahi ʻano hou o ka analgesic kūloko I ka manawa like,
2. He hopena palekana maikaʻi ka Hypericin i ka myocardial ischemia-reperfusion, cerebral ischemia-reperfusion a me ka cerebral infarction.
3. Loaʻa ka Hypericin i ka hopena anti-inflammatory: ma hope o ka hoʻokomo ʻana i ka pōpō huluhulu, ua hoʻopiʻi ʻia nā ʻiole me ka 20mg / kg i kēlā me kēia lā no 7 mau lā, kahi i kāohi nui ai i ke kaʻina hana inflammatory.
4. He hopena antitussive ikaika.
5. Hoʻohuihui.
6. He mea maikaʻi paha ke kāohi ikaika ʻana i ka aldose reductase no ka pale ʻana i ka maʻi maʻi maʻi cataract.
Ka hopena pale i ka myocardial ischemia
Hiki i ka Hypericin ke hoʻemi i ka helu apoptosis o nā cardiomyocytes i hoʻokumu ʻia e ka hypoxia reoxygenation, ke kāohi i ka hoʻokuʻu ʻana o ka lactate dehydrogenase, hoʻomaikaʻi i ka hana o ka myocardial superoxide dismutase (SOD) i nā ʻiole me ka myocardial ischemia-reperfusion injury, hoʻemi i ka hana ʻana o malondialdehyde (MDA), keʻakeʻa i ka hoʻonui i ka myocardial phosphokinase (CPK) i loko o ka serum, a hoʻemi i ka hoʻokumu ʻana o ka radical free radical a me ka nitric oxide free radical, no ka pale ʻana i ka myocardium a hoʻemi i ka hōʻeha cardiomyocyte a me ka apoptosis cardiomyocyte i hana ʻia e ka ischemia-reperfusion.
Ka hopena pale i ka cerebral ischemia
Hiki i ka Hypericin ke pale pono i ka emi ʻana o ka maʻiʻo formazan i nā ʻāpana cerebral ma hope o ka hypoxia glucose deprivation reperfusion hōʻeha, e hoʻonui i ka helu o nā neurons ola i loko o ka cortex a me ka striatum o nā ʻāpana cerebral i ka ischemic wahi, a hana i ka morphology o nā neurons i hoʻopiha a hoʻohele maikaʻi ʻia.Kāohi i ka emi ʻana o ka hana neuronal i hoʻoulu ʻia e ka hypoxia glucose deprivation reperfusion injury.Kāohi i ka emi ʻana o nā hana SOD, LDH a me glutathione peroxidase (GSHPx).Hiki ke pili i kāna hana me ka hoʻoheheʻe ʻana i ka radical manuahi, ka pale ʻana i ka komo ʻana o Ca2 a me ka hoʻokumu ʻana i ka anti lipid peroxide.
Ka hopena pale i ka ate a me ka mucosa o ka ʻōpū
Loaʻa ka Hypericin i ka hopena pale i ka ʻiʻo ate a me ka mucosa ʻōpū.Ua pili kona mīkini i ka hopena antioxidant, e paipai ana i ka hoʻihoʻi ʻana o ka pae N0 i ka maʻamau a me ka hoʻonui ʻana i ka hana SOD.
Ka hopena analgesic antispasmodic
Ua ʻike ʻia ka haʻawina e hana ʻia ka hopena analgesic o hypericin ma o ka hoʻemi ʻana i ka Ca 2 i nā hopena ʻehaʻeha.I ka manawa like, hiki i ka hypericin ke kāohi i ka Ca 2 influx i hoʻoulu ʻia e ka potassium kiʻekiʻe, e hōʻike ana i ka hypericin e hoʻopaʻa pū i ke kahawai Ca i loko o ka ʻiʻo nerve.Manaʻo hou ʻia ʻo hypericin paha he blocker o Ca 2 channel.Hōʻike ka nānā ʻana i ka hypericin injection me ka atropine i ka mālama ʻana i ka dysmenorrhea mua.Ma waho aʻe o nā hopena ʻaoʻao hiamoe, ʻaʻohe hopena ʻino maʻamau e like me tachycardia, mydriasis a me ke ʻano wela.ʻO ia kahi antispasmodic kūpono a me ka analgesic.
Ka hopena hypolipidemic
Hiki i ka Hypericin ke ho'ēmi nui i ka TC serum a hoʻonui i ka ratio HDL / TC i nāʻiole momona kiʻekiʻe, e hōʻike ana e hiki i ka hypericin ke hoʻemi i ka cholesterol, hoʻoponopono i ka lipid koko, a hoʻonui i ka hana o HDL a me ka serum SOD i nāʻiole.Hiki i kēia hopena ke hoʻemi nui i ka pōʻino o ka radical manuahi superoxide i ka endothelium vascular i ka hyperlipidemia, a he mea kūpono i ka decomposition a me ka metabolism o ka lipid peroxide e pale i ka endothelium vascular.
Hoʻonui i ka hana immune
ʻO ka Hypericin ma nā ʻano o 300 mg / kg a me 150 mg / kg i loko o ka vivo hiki ke pale nui i ka thymus index, ka hoʻonui ʻana o ka spleen T a me B lymphocytes a me ka phagocytosis o peritoneal macrophages;Ma ka 59 mg / kg, ua hoʻonui nui ia i ka hoʻonui ʻana o ka spleen T a me B lymphocytes a me ka phagocytosis o peritoneal macrophages.Hiki i ka Hypericin ma ka nui o 50 ~ 6.25 ml in vitro ke hoʻoikaika nui i ka hoʻonui ʻana o ka spleen T a me B lymphocytes a hoʻonui i ka hiki o T lymphocytes e hana i ka IL-2;ʻO Hypericin ma 6.25 g / ml i hoʻonui nui i ka hiki o nā macrophages peritoneal mouse e phagocytize neutrophils, mai 12.5 a 3.12 μG / ml i hoʻonui nui i ka hiki o nā macrophages peritoneal mouse e hoʻokuʻu i No.
Ka hopena antidepressant
ʻO ka Hypothalamic pituitary adrenal (HPA) activation he hoʻololi olaola maʻamau i nā poʻe maʻi me ke kaumaha koʻikoʻi, kahi i hōʻike ʻia e ka huna nui ʻana o ka hormone adrenocorticotropic (ACTH) a me cortisol.Hiki i ka Hypericin ke hoʻoponopono i ka hana o ka axis HPA a hoʻemi i nā pae o ACTH a me corticosterone, i mea e pāʻani ai i kahi hana antidepressant.
Laau Laau Pau
ʻO Ciwujia capsule
ʻO Acanthopanax senticosus capsule he mea hoʻomākaukau me ka ʻōpala Acanthopanax senticosus a me ka lau lau e like me ka mea maka.ʻO ka mea nui he flavonoids, kahi hypericin ka mea hana nui o nā lau Acanthopanax senticosus.
Nā hōʻailona nui: hoʻoikaika i ke kahe koko a hoʻoneʻe i ke koko stasis.Hoʻohana ʻia ia no ka arthralgia umauma a me ka maʻi puʻuwai i hoʻokumu ʻia e ka stasis koko.ʻO nā hōʻailona e pili ana i ka ʻeha o ka umauma, ka paʻa o ka umauma, ka palpitation, hypertension, etc. no ka hemahema o ka spleen a me ka puʻupaʻa a me ke koko stasis a me Yin.
Xinan capsule
He hoʻomākaukau ia i hana ʻia i ka hawthorn leaf extract, kahi waiwai i nā flavonoids, kahi hypericin kekahi o nā mea nui.
Nā hōʻailona nui: hoʻonui i ka ʻōnaehana cardiovascular coronary, hoʻomaikaʻi i ka hāʻawi koko myocardial a hoʻemi i ka lipid koko.Hoʻohana ʻia ia e mālama i ka maʻi naʻau coronary, angina pectoris, ka paʻa o ka umauma, palpitation, hypertension, etc.
Qiyue Jiangzhi papa
ʻO ka papa Qiyue Jiangzhi kahi lāʻau lapaʻau maʻamau Kina maʻemaʻe lipid-lowering lāʻau i hoʻomākaukau ʻia ma ka unuhi ʻana i nā ʻāpana kūpono o ka lāʻau lapaʻau Kina e like me ka hawthorn (enucleated) a me Astragalus membranaceus.ʻO kekahi o nā mea nui o ka hawthorn he flavonoids, kahi kiʻekiʻe o ka hypericin content.
Nā hōʻailona nui: hoʻemi i ka lipid koko a hoʻomaʻamaʻa i nā kīʻaha koko.Hoʻohana ʻia ia e hoʻomaikaʻi i ke kahe koko coronary a hakakā i ka arrhythmia a me hyperlipidemia.
Xinxuening papa
ʻO ka papa Xinxuening kahi hoʻomākaukau hoʻohui i hana ʻia me ka lāʻau lapaʻau Kina e like me ka hawthorn a me ka pueraria.ʻO Hawthorn ka lāʻau lapaʻau o kā mākou pāʻina.Aia ka ursolic acid, Vitexin rhamnoside, hypericin, citric acid, a me nā mea ʻē aʻe, ʻo ia ka hypericin ka mea nui.
ʻO nā hōʻailona nui: ka hoʻoikaika ʻana i ke kahe koko a me ka wehe ʻana i ke koko stasis, dredging collaterals a hoʻomaha i ka ʻeha.Hoʻohana ʻia ia no ka umauma arthralgia a me ka vertigo i hoʻokumu ʻia e ka puʻuwai koko stasis a me ka lolo collaterals, a me ka maʻi naʻau coronary, hypertension, angina pectoris a me hyperlipidemia.
ʻO Yukexin capsule
ʻO Yukexin capsule kahi hoʻomākaukau lāʻau lapaʻau kuʻuna Kina i hoʻomohala ʻia mai kahi lāʻau lapaʻau kahiko, kahi i haku ʻia me Hypericum perforatum, ʻōpala jujube wild, Albizzia bark, Gladiolus a me nā lāʻau lapaʻau Kina.Loaʻa ka nui o ka hypericin, quercetin, quercetin, chlorogenic acid, caffeic acid, ymaning, hypericin a me nā mea ʻē aʻe.
Nā hōʻailona nui: ke kaumaha o ka noʻonoʻo ma muli o ka hoʻomaha ʻole o ka ate qi a me ke ʻano maikaʻi ʻole.
