Obtusin
Hoʻohana i ka Obtusin
ʻO Obtusin, mai ka hua cassia, he mea koho nui a hoʻokūkū hoʻokūkū o ke kanaka monoamine oxidase-A (hmao-a), me ka IC50 o 11.12 μ M. Ki he 6.15.He hana pale ʻo Obtusin i nā maʻi neurodegenerative, ʻoi aku ka hopohopo a me ke kaumaha.
Ka inoa o Obtusin
Inoa Pelekania: Obtusin
Bioactivity o Obtusin
ʻO ka wehewehe: ʻo obtusin mai ka hua cassia.He mea koho nui a hoʻokūkū hoʻokūkū o ke kanaka monoamine oxidase-A (hmao-a), me IC50 o 11.12 μ M. Ki he 6.15.He hana pale ʻo Obtusin i nā maʻi neurodegenerative, ʻoi aku ka hopohopo a me ke kaumaha.
Nā Māhele e pili ana: ala ala hōʻailona > > ala ala neural > > monoamine oxidase
Kahua noiʻi > > maʻi neʻe
Pahuhopu: IC50: 11.12 μ M (hMAO-A)[1] Ki: 6.15 (hMAO-A)[1]
Nānā: [1] Paudel P, et al.In Vitro and in Silico Human Monoamine Oxidase Inhibitory Potential of Anthraquinones, Naphthopyrones, and Naphthalenic Lactones from Cassia obtusifolia Linn Seeds.ACS Omega.2019 Sep 18;4(14):16139-16152.
Na waiwai kino o Obtusin
Māmā: 1.4 ± 0.1 g / knm3
Puni paila: 614.9 ± 55.0 ° C ma 760 mmHg
Ke Kumu Molekala: c18h16o7
Kaumaha Molekala: 344.315
Laila Uila: 227.0 ± 25.0 ° C
Nuipa pololei: 344.089600
PSA:102.29000
LogP:4.10
Pumi mahu: 0.0 ± 1.8 mmHg ma 25 ° C
Hōʻike Hōʻikeʻike: 1.634
ʻIke palekana Obtusin
Code Dute: 2914690090
Moʻolelo: Cameron, Donald W;Feutrill, Geoffrey I.;Gamble, Glenn B.;Stavrakis, John Tetrahedron Letters, 1986, vol.27, # 41 p.4999 - 5002
Obtusin Dute
Code Dute: 2914690090
Manaʻo Pākē: Manaʻo Pākē
Hōʻuluʻulu manaʻo: 2914690090 mau quinones ʻē aʻe. Kūlana kiaʻi: ʻAʻohe. VAT: 17.0% 。 Laki ʻauhau: 9.0% . ʻO ka uku MFN: 5.5% . Ka uku nui: 30.0%
English Alias of Customs
9,10-Anthracenedione, 1,7-dihydroxy-2,3,8-trimethoxy-6-methyl-
1,7-dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione
1,7-Dihydroxy-2,3,8-trimethoxy-6-methyl-9,10-anthraquinone
Hoʻoholo maikaʻi o ka huahana
1. Ua kūʻai aku ka hui i ka nuklea magnetic resonance (Bruker 400MHz) spectrometer, liquid phase mass spectrometer (LCMS), gas phase mass spectrometer (GCMs), mass spectrometer (water SQD), mau analytical automatic high performance liquid chromatographs, preparative liquid chromatographs, etc. .
2. Mālama ka hui i ka launa pū ʻana a me ka launa pū ʻana me nā keʻena noiʻi ʻepekema e like me Shanghai Institute for drug control, Nanjing biomedical public service platform and analysis and testing center of Shanghai Pharmaceutical Industry Research Institute.
3. Ke hoʻokō nei ka hui i ka palapala hōʻoia hoʻokolohua ʻekolu ʻaoʻao, a ua manaʻo ʻia e loaʻa iā CNAs Laboratory Accreditation Certificate ma 2021.
