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Tanshinone IIA

ʻO ka wehewehe pōkole:

Inoa maʻamau: tanshinone IIA

Inoa Pelekania: tanshinone IIA

Ka helu CAS: 568-72-9

Kaumaha Molekala: 294.344

Māmā: 1.2 ± 0.1 g / cm3

Puni paila: 480.7 ± 44.0 ° C ma 760 mmHg

Ke Kumu Molekala: c19h18o3

Ka helu hehee: 205-207 º C

Kekahi uila: 236.4 ± 21.1 ° C


Huahana Huahana

Huahana Huahana

Keʻano mālama

ʻO Tanshinone IIA (Tan IIA) kekahi o nā mea momona momona nui i loko o nā aʻa o ke aʻa ʻulaʻula Salvia miltiorrhiza.Hiki i ka Tanshinone IIA ke pale i ka angiogenesis ma ka huli ʻana i ka protein kinase domain o VEGF / VEGFR2.

Ka inoa o Tanshinone IIA

inoa Pelekania:tanshinone IIA
Nā inoa Pākē:tanshinone |tanshinone IIA |tanshinone 2A |tanshinone IIA |tanshinone IIA hana olaola

wehewehe:
ʻO Tanshinone IIA (Tan IIA) kekahi o nā mea momona momona nui i loko o nā aʻa o ke aʻa ʻulaʻula Salvia miltiorrhiza.Hiki i ka Tanshinone IIA ke pale i ka angiogenesis ma ka huli ʻana i ka protein kinase domain o VEGF / VEGFR2.

Nā waeʻano pili:
Kahua noiʻi > > maʻi naʻau
Nā Huahana Kūlohelohe > > Quinones

Pahuhopu:
VEGF/VEGFR2[1]

Haʻawina In Vitro:ʻO nā hopena antitumor o ka tanshinone IIA me ka pale ʻana i ka hoʻonui ʻana o ka cell tumor, ka hoʻopilikia ʻana i ka pōʻai cell tumor, ka hoʻoulu ʻana i ka apoptosis cell tumo a me ka pale ʻana i ka hoʻouka ʻana o ka cell tumor a me ka metastasis.Ua loaʻa i ka Tanshinone IIA ka hopena anti proliferative ma nā pūnaewele A549: ʻo ka IC50 o tanshinone IIA ma hope o 24, 48 a me 72 mau hola he 145.3, 30.95 a me 11.49, kēlā me kēia μ M. CCK-8 assay i hoʻohana ʻia e loiloi i ka tanshinone IIA (2.5-80 μM). ʻO ka hana proliferative o nā cell A549 i mālama ʻia ma 24, 48 a me 72 mau hola.Ua hōʻike nā hualoaʻa CCK-8 e hiki i ka tanshinone IIA ke kāohi nui i ka hoʻonui ʻana o nā cell A549 ma kahi ʻano hilinaʻi a hilinaʻi i ka manawa.Ua ʻike ʻia ka nui o ka apoptosis a me ka pale ʻana i ka ulu ʻana o nā cell A549 i nā hola 48 ma hope o ka mālama ʻana i ka lāʻau (ʻo ka manaʻo i hoʻohana ʻia e pili ana i ka waiwai IC50: tanshinone iia31 ma A549) μ M)。 Ua hōʻike ʻia ka blotting Western i ka ʻike ʻana i ka tanshinone IIA (31) ma nā cell A549 no 48 mau hola. μ M), i lalo e hoʻoponopono i ka hōʻike o VEGF a me VEGFR2 protein i ka hui lāʻau lapaʻau a me ka vector [1].ʻO Tanshinone IIA kekahi o nā mea nui loa o ke aʻa Salvia miltiorrhiza, hiki ke pale aku i nā cell H9c2 mai apoptosis.ʻO nā pūnaewele H9c2 i mālama ʻia me ka tanshinone IIA i kāohi i ka angiotensin II i hoʻokomo ʻia i ka apoptosis ma o ka hoʻoponopono ʻana i ka ʻōlelo o PTEN (phosphatase a me tensin homologue).ʻO ka PTEN kahi mea hoʻopau puʻupuʻu e hana nui i ka apoptosis.Kāohi ʻo Tanshinone IIA i ka angiotensin II (AngII) - i hoʻokomo ʻia i ka apoptosis ma o ka hoʻoponopono ʻana i ka ʻōlelo o ka phosphatase a me ka tensin homologue (PTEN) [2].Hoʻemi ʻo Tanshinone IIA i ka hōʻike protein o EGFR, a pale ʻo IGFR i ke ala PI3K / Akt / mTOR i loko o nā pūnaewele AGS maʻi ʻōpū [3].

ʻO ka hoʻokolohua kelepona:Ua helu ʻia nā cell A549 i ka māhele logarithmic a me 6000 cell (90 μL volume) ma 96 well plate.E 10 μ L nā mana'o like'ole o ka tanshinone IIA (nā hopena hope loa 80,60,40,30,20,15,10,5 a me 2.5 μ M) A me ADM (nā ho'opa'a hope loa 8,4,2,1,0.5 a me 0.25 μ M ) Ua hoʻohui ʻia i ka hui lāʻau lapaʻau, ʻoiai ʻo ka hui hoʻomalu maikaʻi ʻole (hui lawe lawe) ua hoʻohui wale ʻia ʻo 10 μ Ldmso a i ʻole saline maʻamau me ka tanshinone IIA a i ʻole Adm. Hoʻohui i nā cell me CCK-8 reagent (100 μ L / ml medium) no ka he 2 mau hola hou, a ua heluhelu ʻia ka absorbance ma 450 nm me ka hoʻohana ʻana i kahi mea heluhelu microplate.Hoʻohālikelike ʻia ka nui o ka hoʻonui ʻana o ka cell e like me ke ʻano: proliferation inhibition rate (%) = 1 - [(A1-A4) / (A2-A3)] × 100, kahi A1 ka waiwai OD o ka hui hoʻokolohua lāʻau. ʻO A2 ka waiwai OD o ka pūʻulu mana blank, ʻo A3 ka waiwai OD o RPMI1640 medium me ka ʻole o nā pūnaewele, a ʻo A4 ka waiwai OD o ka lāʻau lapaʻau me ka manaʻo like me A1 akā me ka ʻole o nā cell.Ua helu ʻia ka waiwai IC50 e ka loiloi regression nonlinear me ka hoʻohana ʻana i ka polokalamu graphpad prism [1], e hōʻike ana i ka ʻike lāʻau lapaʻau e hōʻike ana i ka 50% cell growth inhibition.

Kuhikuhi:[1].Xie J, et al.ʻO ka hopena antitumor o tanshinone IIA ma ka anti-proliferation a me ka hoʻohaʻahaʻa ʻana i ka hōʻike VEGF / VEGFR2 ma ke kanaka liʻiliʻi liʻiliʻi liʻiliʻi maʻi maʻi maʻi maʻi A549 cell line.Acta Pharm Sin B. 2015 Nov;5(6):554-63.
[2].Zhang Z, et al.Kāohi ʻo Tanshinone IIA i ka apoptosis i ka myocardium ma o ka hoʻoulu ʻana i ka ʻōlelo microRNA-152-3p a laila hoʻohaʻahaʻa i ka PTEN.Am J Transl Res.2016 Iulai 15;8(7):3124-32.
[3].Su CC, et al.Hoʻemi ʻo Tanshinone IIA i ka hōʻike protein o EGFR, a ke kāohi nei ʻo IGFR i ke ala PI3K/Akt/mTOR i loko o nā pūnaewele AGS carcinoma ʻōpū i loko o ka vitro a me ka vivo.ʻO Oncol Rep. 2016 Aug;36(2):1173-9.

Nā waiwai kino o ka tanshinone IIA

Māmā: 1.2 ± 0.1 g / knm3

Puni paila: 480.7 ± 44.0 ° C ma 760 mmHg

Ka helu hehee: 205-207 º C

Ke Kumu Molekala: c19h18o3

Kaumaha Molekala: 294.344

Laila Uila: 236.4 ± 21.1 ° C

Nuipa pololei: 294.125580

PSA:47.28000

LogP:5.47

Nānā: Crystal

Pumi mahu: 0.0 ± 1.2 mmHg ma 25 ° C

Hōʻike Hōʻikeʻike: 1.588

Kūlana mālama: 2-8 ° C

ʻIke Palekana ʻo Tanshinone IIA

Nā Lako Palena Pilikino: nā pale maka;Nā mīkina lima;ʻano N95 (US);ʻano P1 (EN143) kānana respirator

Code Transport Of Dangerous Goods: nonh no nā ʻano kaʻa a pau

Tanshinone IIA Moolelo

Code Dute: 2942000000

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Tanshinone IIA English Alias

Phenanthro[1,2-b]furan-10,11-dione, 6,7,8,9-tetrahydro-1,6,6-trimethyl-

Tanshinone IIA

tanshinone II-A

ʻO Dan Shen Ketone

Tanshionesiia

Tanshine II

TANSHION PE

1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione

ʻAlani ʻAlani

MFCD00238692

QS-D-77-4-2

ʻO TANSHINONE A

ʻO Tanshiones

Tanshinone II


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