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Cov khoom

Astragaloside IV CAS No. 84687-43-4

Lus piav qhia luv luv:

Astragaloside IV yog cov khoom siv organic nrog cov tshuaj formula C41H68O14.Nws yog dawb crystalline hmoov.Nws yog ib qho tshuaj rho tawm los ntawm Astragalus membranaceus.Lub ntsiab active Cheebtsam ntawm Astragalus membranaceus yog astragalus polysaccharides, Astragalus saponins thiab Astragalus isoflavones, Astragaloside IV yog tsuas yog siv raws li tus qauv los ntsuas qhov zoo ntawm Astragalus.Pharmacological cov kev tshawb fawb qhia tau hais tias Astragalus membranaceus muaj cov teebmeem ntawm kev txhim kho kev tiv thaiv kab mob, ntxiv dag zog rau lub plawv thiab txo cov ntshav siab, txo cov ntshav qabzib, diuresis, tiv thaiv kev laus thiab tiv thaiv qaug zog.


Product Detail

Khoom cim npe

Lus Taw Qhia

English Alias:Astragaloside IV;beta-D-Glucopyranoside, (3beta, 6alpha, 16beta, 24R)-20,24-epoxy-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl;(3beta,6alpha,9beta,16beta,20R,24S)-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy)-20,24-epoxy-9,19-cyclolanostan-6-yl beta-D-threo - hexopyranoside

Molecular Formula:C41H68O14

Lub npe tshuaj:17-[5-(1-Hydroxyl-1-methyl-ethyl)- 2methyl-tetrahydro- furan-2-yl]-4,4,13,14-tetramethyl-tetradecahydro-cyclopropa[9,10]cyclopenta[a] Phenanthren-16-ol-3-β-D-aracopyranosyl-6-β-D- glucoside

Mp:200 ~ 204 ℃

[α]D:-56.6 (c, 0.13 hauv DMF)

UV:ua 203nm

purity:98%

Qhov chaw:Astragalus membranaceus, Astragalus pubescens.

Cov qauv tshuaj formula ntawm astragaloside IV

Cov qauv tshuaj formula ntawm astragaloside IV

Physicochemical Properties

[zoo li]:dawb crystalline hmoov

[purity]:saum toj 98%, txoj kev kuaj pom: HPLC

[cog qhov chaw]:Cov hauv paus hniav ntawm Astragalus Alexandrinus Boiss, Astragalus dissectus, Astragalus membranaceus (Fisch.) Bungede cag, Astragalus sieversianus Pall Root ntawm Astragalus spinosus Vahl, aerial ib feem ntawm Astragalus spinosus Vahl.

[cov khoom siv]:Astragalus membranaceus extract yog xim av daj hmoov.

[Kev txiav txim siab cov ntsiab lus]:txiav txim los ntawm HPLC (Appendix VI D, Volume I, Chinese Pharmacopoeia, 2010 Edition).

Chromatographic tej yam kev mob thiab system applicability test} octadecyl silane bonded silica gel yog siv raws li muab tub lim, acetonitrile dej (32:68) yog siv raws li mobile theem, thiab evaporative lub teeb scattering detector yog siv los tshawb nrhiav.Tus lej ntawm cov phiaj xwm theoretical yuav tsum tsis pub tsawg dua 4000 raws li astragaloside IV ncov.

Kev npaj cov kev daws teeb meem, siv qhov tsim nyog ntawm astragaloside IV siv, ntsuas qhov tseeb, thiab ntxiv methanol los npaj cov tshuaj uas muaj 0.5mg ib 1ml.

Kev npaj cov tshuaj ntsuam xyuas:noj txog 4G ntawm cov hmoov los ntawm cov khoom no, ntsuas nws kom raug, muab tso rau hauv Soxhlet extractor, ntxiv 40ml ntawm methanol, tsau rau ib hmos, ntxiv ib qho tsim nyog ntawm methanol, cua sov thiab reflux rau 4 teev, rov qab cov kuab tshuaj los ntawm cov extract thiab mloog zoo. nws kom qhuav, ntxiv 10ml dej kom yaj cov residue, co thiab rho tawm nrog saturated n-butanol rau 4 zaug, 40ml txhua lub sij hawm, muab n-butanol tov, thiab ntxuav nws tag nrho nrog ammonia test tov rau 2 zaug, 40ml txhua. Lub sij hawm, muab pov tseg cov tshuaj ammonia, evaporate cov tshuaj n-butanol, ntxiv 5ml dej kom yaj cov residue, thiab txias nws, Los ntawm D101 macroporous adsorption resin kem (sab hauv kab: 37.5px, kem qhov siab: 300px), elute nrog 50ml dej. , muab pov tseg cov dej tov, elute nrog 30ml ntawm 40% ethanol, pov tseg lub eluent, elute nrog 80ml ntawm 70% ethanol, sau cov eluent, evaporate nws mus rau qhuav, dissolve qhov seem nrog methanol, hloov mus rau 5ml volumetric hwj, ntxiv. methanol rau qhov ntsuas, co zoo, thiabces tau.

Txoj kev txiav txim:yog nqus tau 10% ntawm kev siv tshuaj raws li μ l, 20 μl.Test tov 20 txhua μl.Txhaj nws mus rau hauv cov kua chromatograph, txiav txim siab nws, thiab xam nws nrog lub logarithm sib npaug ntawm cov txheej txheem sab nraud ob-taw tes.

Muab xam raws li cov khoom qhuav, cov ntsiab lus ntawm astragaloside IV (c41h68o14) yuav tsum tsis txhob tsawg dua 0.040%

Pharmacological Action

Lub ntsiab zoo ntawm Astragalus yog polysaccharides thiab astragaloside.Astragaloside muab faib ua astragaloside I, astragaloside II thiab astragaloside IV.Ntawm lawv, astragaloside IV, astragaloside IV, muaj cov haujlwm lom neeg zoo tshaj plaws.Astragaloside IV tsis tsuas yog muaj cov nyhuv ntawm Astragalus polysaccharides, tab sis kuj muaj qee qhov cuam tshuam tsis zoo ntawm Astragalus polysaccharides.Nws txoj kev siv zog yog ntau tshaj li ob zaug ntawm cov pa astragalus polysaccharides, thiab nws cov tshuaj tiv thaiv kab mob yog 30 npaug ntawm Astragalus polysaccharides.Vim nws cov ntsiab lus tsawg thiab cov nyhuv zoo, nws tseem hu ua "super astragalus polysaccharide".

1. Txhim khu kev tiv thaiv kab mob thiab tiv thaiv kab mob.
Nws tuaj yeem tshwj xeeb thiab tsis tshwj xeeb cais tawm txawv teb chaws invading lub cev, txhawb kev tiv thaiv tshwj xeeb, tiv thaiv kab mob thiab nonspecific, thiab txhim kho cov kab mob ntawm lub cev.Nws tuaj yeem txhawb kev tsim cov tshuaj tiv thaiv kab mob, thiab txhim kho tus naj npawb ntawm cov tshuaj tiv thaiv kab mob tsim cov hlwb thiab cov nqi kuaj hemolysis.Astragaloside IV tuaj yeem txhim kho qib lymphocyte hloov pauv thiab E-rosette tsim tus nqi ntawm coccidia tiv thaiv qaib.Nws yog ib qho zoo activator ntawm monocyte macrophage system.Astragaloside IV kuj tuaj yeem txhim kho oxidation, GSH-Px thiab SOD cov dej num hauv lub cev tiv thaiv kab mob, thiab txhim kho kev tiv thaiv kab mob thiab kev tiv thaiv kab mob.

2.Antiviral nyhuv.
Nws txoj cai tiv thaiv kab mob: txhawb kev ua haujlwm ntawm macrophages thiab T hlwb, nce tus naj npawb ntawm E-ntiv nplhaib tsim cov hlwb, ua rau cytokines, txhawb kev induction ntawm interleukin, thiab ua rau tsiaj lub cev tsim endogenous interferon, thiaj li ua tiav lub hom phiaj ntawm cov tshuaj tua kab mob.Cov txiaj ntsig tau pom tias tag nrho cov kev tiv thaiv ntawm astragaloside IV ntawm IBD yog 98.33%, uas tuaj yeem tiv thaiv thiab kho IBD, thiab tsis muaj qhov sib txawv tseem ceeb piv nrog cov tshuaj tiv thaiv kab mob siab qe qe.Astragaloside tuaj yeem txhim kho kev ua haujlwm ntawm cov enzymes antioxidant hauv lub cev, txo cov ntsiab lus ntawm LP0, txo qhov kev puas tsuaj ntawm cov pa oxygen reactive, thiab yog li txo qhov xwm txheej thiab kev tuag ntawm MD.Nws tuaj yeem txhim kho qhov tsis muaj zog tiv thaiv kab mob los ntawm cov qog, txhawb kev ua kom lub cev tiv thaiv kab mob, tso cov khoom endogenous, thiab tiv thaiv kev tua thiab inhibition ntawm cov qog hlwb tshwm sim los ntawm peroxidation;Astragaloside a tuaj yeem cuam tshuam kev loj hlob ntawm tus kab mob khaub thuas thiab kev ua haujlwm ntawm sialidase.Nws muaj cov txiaj ntsig tseem ceeb ntawm kev ua haujlwm ntawm tus kab mob khaub thuas kab mob cell membrane thiab adsorption thiab nkag mus ntawm tus kab mob mus rau cov hlwb rhiab heev.Kev tuag thiab qe tso tus nqi ntawm cov nqaij qaib tau txo qis heev, thiab cov qe qe thiab cov qe qe zoo rov qab zoo dua li cov pawg tswj hwm amantadine nkaus xwb, thiab cov nyhuv ntawm Astragalus polysaccharide tsis pom tseeb;Astragaloside IV muaj zog tua thiab inhibitory cuam tshuam ntawm tus kab mob.Lub hauv paus ntsiab lus yog tias kev siv astragaloside IV yog ua ntej nrhiav pom tus kab mob Nd, yog li nws yog qhov zoo tshaj plaws los siv astragaloside IV rau lub sijhawm ntev, Avian myeloblastic leukemia (AMB) 3 hnub qub AA broilers pub astragaloside IV nrog tus kab mob. ntawm AMB tus kab mob, tuaj yeem txo qis qhov tshwm sim thiab kev tuag ntawm AMB, nce LPO cov ntsiab lus hauv lub cev tiv thaiv kab mob xws li spleen thiab thymus, ua kom muaj txiaj ntsig zoo ntawm tus po thiab thymus thiab lwm yam kab mob hauv lub cev ntawm myeloid derived qog hlwb.Qhov thib ob, astragaloside IV muaj kev tiv thaiv thiab kho cov teebmeem ntawm cov kab mob ua pa xws li kab mob laryngotracheitis.Siv.

3. Los tiv thaiv kev ntxhov siab.
Astragaloside IV tuaj yeem tiv thaiv adrenal hyperplasia thiab thymus atrophy hauv lub sijhawm ceeb toom ntawm kev ntxhov siab, thiab tiv thaiv qhov txawv txav ntawm lub sijhawm tiv thaiv thiab lub sijhawm tsis ua haujlwm ntawm kev ntxhov siab, yog li ua lub luag haujlwm tiv thaiv kev ntxhov siab, tshwj xeeb tshaj yog muaj kev tswj hwm ob txoj hauv kev. cuam ​​tshuam rau cov enzymes hauv cov txheej txheem ntawm cov khoom noj metabolism, thiab txo thiab tshem tawm qhov cuam tshuam ntawm kev ntxhov siab kub ntawm lub cev kev ua haujlwm ntawm lub cev mus rau qee yam.

4. Ua tus txhawb nqa kev loj hlob.
Nws tuaj yeem txhim kho cov metabolism hauv lub cev ntawm cov hlwb, txhawb cov ntshav ncig, txhim kho cov metabolism hauv tsiaj lub cev, thiab ua lub luag haujlwm ntawm kev noj haus thiab kev noj qab haus huv.Kev tshawb fawb qhia tau hais tias nws tuaj yeem txhawb kev loj hlob ntawm bifidobacteria thiab lactic acid cov kab mob thiab muaj cov nyhuv ntawm probiotics.

5. Astragaloside IV tuaj yeem txhim kho cardiopulmonary muaj nuj nqi.
Txhim kho lub plawv contractility, tiv thaiv myocardium thiab tiv thaiv lub plawv tsis ua hauj lwm.Nws kuj muaj cov teebmeem ntawm kev tiv thaiv daim siab, tiv thaiv inflammatory thiab analgesic.Nws tuaj yeem siv los ua kev kho mob ntxiv rau ntau yam kab mob thiab kab mob.


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