Cycloastragenol CAS No. 78574-94-4
Khoom Specification
[npe]:cycloastragal cawv
[alias]:triterpenoid cyclic flavonol
[English lub npe]:cycloastragenol
[molecular formula]:C30H50O5
[molecular hnyav]:490.71 ib
[CAS Nr.]:78574-94-4 ib
[Nrhiav txoj kev]:HPLC ≥ 98%
[Specification]:20mg 50mg 100mg 500mg 1g (tuaj yeem ntim tau raws li cov neeg siv khoom xav tau)
[cov khoom]:Cov khoom no yog xim tsis muaj xim acicular crystal
[muaj nuj nqi thiab siv]:Cov khoom no yog siv rau kev txiav txim siab cov ntsiab lus, kev txheeb xyuas, kev sim tshuaj, kev tshuaj xyuas kev ua haujlwm thiab lwm yam kev tshawb fawb tshawb fawb.Xws li kev tswj hwm ntawm tes, kev ntsuam xyuas intragastric, kev tshuaj xyuas sab hauv ntawm cov chaw muag tshuaj, thiab lwm yam.Source: Astragalus membranaceus (Fisch.) Bge.Qhuav cag extract
Txoj kev khaws cia
2-8 ° C, kaw los ntawm lub teeb thiab khaws cia ntawm qhov kub thiab txias.
Nco tseg
Cov khoom no yuav tsum tau khaws cia ntawm qhov kub thiab txias.Yog tias nws raug huab cua ntev ntev, cov ntsiab lus yuav raug txo.
Chromatographic tej yam kev mob} chromatographic kem: Zorbax rx-c18 (4.6mm) × 150mm), 5 μ m； Mobile theem: acetonitrile dej (30:70);Flow tus nqi: 1.0ml / min, kem kub: 35 ℃, ELSD tsis: drift tube kub: 105 ℃, nitrogen txaus tus nqi: 2.70ml / min.
Physicochemical zog: ceev 1.20
Bioactivity ntawm cycloastragenol
Cycloastragalol yog ib qho triterpene saponin compound, uas yog Astragalus membranaceus (Fisch.) Hydrolyzate ntawm cov khoom xyaw nquag hauv Bunge).Astramembrangenin muaj kev nyab xeeb ntawm qhov ncauj thiab muaj ntau yam tshuaj muaj txiaj ntsig, suav nrog kev ua kom telomerase, telomere prolongation, anti-inflammatory thiab antioxidant zog.Astramembrangenin muaj cov khoom tiv thaiv kev laus.CAG txhawb nqa kev ua haujlwm telomerase hauv tib neeg cov keratinocytes yug tshiab thiab nas paj hlwb thiab ua rau CREB ua kom muaj zog.Astramembrangenin tuaj yeem muaj cov tshuaj kho tshiab hauv kev nyuaj siab
Pawg muaj feem:
Kev taw qhia txoj kev > > apoptosis > > apoptosis
Kev tshawb fawb teb >> mob / tiv thaiv kab mob
Kev tshawb fawb teb > > kab mob neurological
Kev tshawb fawb hauv Vitro:
Piv nrog rau kev tswj cov cab kuj hauv HEK kab lis kev cai, lub hnub qub membrane protein (0-10 μ M; 3-6 hnub) nce cell loj hlob [1].Astramembrangenin (0.3 μ M;5-90 feeb) induced CREB phosphorylation hauv thawj cortical neurons, thiab kev qhia tag nrho CREB hauv ob hom cell tsis cuam tshuam los ntawm CAG [1].Star membrane protein (3) μ M;6-48 teev) tuaj yeem txhawb nqa hauv vivo teeb liab hloov pauv hauv cov neurons, nce TERT mRNA qhia, thiab qhia tau nce bcl 2 mRNA qhia [1].Cell viability assay [1] cell kab: HEK cell concentration: 1 μ M, 3 μ M, 10 μ M kab lis kev cai lub sij hawm: 3-6 hnub tau: cell loj hlob ob zaug ntawm 6 hnub.Western blot tsom xam [1] kab ntawm tes: neuron cell concentration: 0.3 μ M kab lis kev cai lub sij hawm: 5 feeb, 15 feeb, 30 feeb, 90 feeb.Cov txiaj ntsig: CAG induced CREB activation in neurons.RT-PCR [1] kab ntawm tes: neuron cell concentration: 3 μ M kab lis kev cai lub sij hawm: 6-48 teev cov txiaj ntsig: kev qhia ntawm TERT thiab Bcl 2 mRNA nce.
Siv:
[1].Ip FC, et al.Cycloastragenol yog lub zog telomerase activator hauv cov hlwb neuronal: cuam tshuam rau kev tswj kev nyuaj siab.Neurosignals.2014; 22(1:52-63.
[2].Yus Y, et al.Cycloastragenol: Ib tus neeg sib tw tshiab zoo siab rau cov kab mob muaj hnub nyoog.Exp Ther Med.2018 Sep; 16(3): 2175-2182.
[3].Sun C, et al.Cycloastragenol mediates activation thiab proliferation suppression nyob rau hauv concanavalin A-induced nas lymphocyte pan-activated qauv.Immunopharmacol Immunotoxicol.2017 Lub Ib Hlis; 39(3): 131-139.
Physicochemical Properties Ntawm Cycloastragenol
Ceev:1.2 ± 0.1 g / cm3
Boiling point:617.2 ± 55.0 ° C ntawm 760 mmHg
Melting point:241.0 txog 245.0 ° C
Molecular formula:c30h 5
Molecular Luj:490.715 ib
Flash point:327.1 ± 31.5 ° C
Raws li pawg:490.365814 ib
PSA:90.15.000 Nws
LogP:3.82 ib
Chav siab:0.0 ± 4.0 mmHg ntawm 25 ° C
Refractive Index:1.582 ib
Cycloastragenol Safety Information
Kev thauj mus los ntawm cov khoom txaus ntshai: nonh rau txhua hom kev thauj
RTECS tus lej;GX8265000
PIB: 294200000
Cycloastragalol Kev lis kev cai
PIB: 294200000
Cycloastragalol Literature
Cycloastragenol yog lub zog telomerase activator hauv cov hlwb neuronal: cuam tshuam rau kev tswj kev nyuaj siab.
Neurosignals 22(1), 52-63, (2014)
Cycloastragenol (CAG) yog ib qho aglycone ntawm astragaloside IV.Nws tau pom thawj zaug thaum kuaj Astragalus membranaceus extracts rau cov khoom xyaw nquag nrog cov khoom tiv thaiv.Txoj kev tshawb no ntawm ...
Ib tug tshiab telomerase activator suppresses lub ntsws puas nyob rau hauv ib tug murine qauv ntawm idiopathic pulmonary fibrosis.
PLoS ONE 8(3), e58423, (2013)
Qhov tshwm sim ntawm cov kab mob cuam tshuam nrog telomere tsis ua haujlwm, suav nrog AIDS, aplastic anemia thiab pulmonary fibrosis, tau txhawb kev txaus siab rau telomerase activators.Peb qhia txog kev txheeb xyuas tus n...
Telomerase-based pharmacologic txhim kho kev ua haujlwm ntawm kev ua haujlwm ntawm tib neeg CD8 + T lymphocytes.
J. Immunol.181(10), 7400-6, (2008)
Telomerase thim rov qab transcribes telomere DNA mus rau qhov kawg ntawm cov kab chromosomes thiab retards cellular aging.Nyob rau hauv sib piv rau feem ntau ib txwm somatic hlwb, uas qhia me ntsis los yog tsis muaj telomerase kev ua, tshuaj tiv thaiv ...
English Alias ntawm Cycloastragalol
9,19-Cyclolanostane-3,6,16,25-tetrol, 20,24-epoxy-,(3β,6α,9β,16β,20R,24S)-
Astramembrangenin
(3β,6α,9β,16β,20R,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
19-Cyclolanostane-3,6,16,25-tetrol, 20,24-epoxy-,(3β,6α,9β,16β,20R,24R)-
(3β,6α,9β,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
Cyclosieversigenin
Cyclogalegigenin
