Cov khoom

Nqe lus piav qhia:glucoridin yog ib qho isoflavane los ntawm glycorrhiza glabra, uas tuaj yeem khi thiab qhib PPAR γ, EC50 tus nqi yog 6115 nm.Glabridin muaj antioxidant, tshuaj tua kab mob, tiv thaiv glomerulonephritis, tiv thaiv ntshav qab zib, tiv thaiv qog, tiv thaiv kab mob, tiv thaiv pob txha, tiv thaiv kab mob plawv, tiv thaiv cov hlab ntsha, tshem tawm cov dawb radicals thiab lwm yam haujlwm.

Pawg muaj feem:kev tshawb fawb teb > > mob cancer
Kev taw qhia txoj hauv kev > > cell voj voog / DNA puas > > PPAR
Kev tshawb fawb teb >> mob / tiv thaiv kab mob

Kev tshawb fawb hauv Vitro:glabridin khi thiab qhib PPAR γ, EC50 yog 6115 nm [1].Glabridin (40,80 μ M) Kev loj hlob ntawm SCC-9 thiab SAS cov kab ntawm tes tau raug cuam tshuam rau hauv ib koob tshuaj thiab lub sijhawm nyob ntawm kev kho mob tom qab 24 thiab 48 teev [2].Glabridin (0-80 μ M) Nws kuj induces apoptosis, ua rau sub G1 cell voj voog ntes hauv SCC-9 thiab SAS cell kab [2].Glabridin (0,20,40 thiab 80 μ M) Dose dependently activated Caspase-3, - 8 thiab - 9 thiab nce PARP cleavage, ho phosphorylating ERK1 / 2, JNK1 / 2 thiab P-38 MAPK hauv SCC-9.Cells [2].

Hauv Vivo Study:glabridin (50 mg / kg, Po ib hnub ib zaug) tau pom muaj zog tiv thaiv kev ua haujlwm thiab txhim kho cov kev hloov pauv uas tshwm sim los ntawm dextran sodium sulfate (DSS) [3]

Cov ntaub ntawv:[1] Rebhun JF, et al.Kev txheeb xyuas ntawm glabridin raws li bioactive compound hauv licorice (Glycyrrhiza glabra L.) extract uas ua rau tib neeg peroxisome proliferator-activated receptor gamma (PPAR γ).Fitoterapia.Peb Hlis 2015;106:55-61.
[2].Chen CT, et al.Glabridin induces apoptosis thiab cell voj voog ntes nyob rau hauv lub qhov ncauj kab mob hlwb los ntawm JNK1/2 signaling txoj kev.Environ Toxicol.Lub Rau Hli 2018;33(6):679-685 : kuv.
[3].El-Ashmawy NE, et al.Kev txo qis ntawm iNOS thiab nce ntawm cAMP kho kom haum rau cov tshuaj tiv thaiv kab mob ntawm glabridin hauv cov nas uas muaj kab mob ulcerative.Inflammopharmacology.2018 Plaub Hlis Ntuj;26(2:551-559) ib.