Isoliquiritin Apioside
Aplikasyon Isoliquiritin Apioside
Isoliquiritin apioside, yon eleman izole nan glycorrhizae radyo rhome, siyifikativman redwi PMA pwovoke ogmantasyon nan aktivite MMP9 ak inibit PMA pwovoke MAPK ak deklanchman NF-κ B.Isoliquitin apioside inibit envazyon an ak anjyogenesis nan selil kansè yo ak selil andotelyal yo.
Non Isoliquiritin Apioside
Non Chinwa:Isoliquiritin Apioside
Non angle:(E)-3-[4-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl] oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
Byoaktivite Isoliquiritin Apioside
Deskripsyon:isoliquitin apioside, yon eleman izole nan glycorrhizae radyo rhome, siyifikativman redwi PMA pwovoke ogmantasyon nan aktivite MMP9 ak inibit PMA pwovoke MAPK ak deklanchman NF-κ B.Isoliquitin apioside inibit envazyon an ak anjyogenesis nan selil kansè yo ak selil andotelyal yo.
Ki gen rapòCkategori:domèn rechèch > > kansè
Chemen siyal > > chemen siyal MAPK / ERK > > p38 MAPK
Chemen siyal > > metabolik anzim / proteaz > > MMP
Sib:MMP9
NF-κB
p38 MAPK
Etid in vitro:isorlicin te kapab efektivman anpeche aktivite gelation MMP-9 nan selil HT1080 PMA pwovoke.Isoglycyrrhizin apigenin diminye ogmantasyon nan pwodiksyon MMP-9 nan selil HT1080 pwovoke pa PMA, gen kapasite nan anti metastaz ak anti anjojenèz nan selil timè malfezan ak selil endothelial, epi li pa gen okenn sitotoksisite [1].
Referans:[1].Kim A1, et al.Isoliquiritin Apioside siprime anvayisman an vitro ak anjojenèz nan selil kansè yo ak selil andotelyal.Front Pharmacol.2018 Desanm 10;9:1455.
Pwopriyete fizikochimik Isoliquiritin Apioside
Dansite: 1.6 ± 0.1 g / cm3
Pwen bouyi: 901.0 ± 65.0 ° C nan 760 mmHg
Fòmil molekilè: c26h30o13
Pwa molekilè: 550.509
Flash pwen: 301.9 ± 27.8 ° C
Mas egzat: 550.168640
PSA:215.83000
LogP: 1.96
Presyon vapè: 0.0 ± 0.3 mmHg nan 25 ° C
Endèks refraktif: 1.709
Angle alyas Isoliquiritin Apioside
2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-[4-[[2-O-[(2S,3R,4R)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl )-2-furanyl]-β-D-glucopyranosyl]oxy]phenyl]-, (2E)-
3-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl]phenyl 2-O-[(2S,3R,4R)-3,4-dihydroxy-4 -(hydroxymethyl)tetrahydro-2-furanyl]-β-D-glucopyranoside
Neolikurozid
