Ophiopogonin D Cas No.945619-74-9
Non Ophiopogon Saponin D
Non angle:(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside
Byoaktivite Ophiopogon Japonicus Saponin D
Deskripsyon:Ophiopogon D se yon ra natirèl C29 glikozid esteroyid izole nan tubèrkul Ophiopogon japonicus.Ophiopogonin D se yon pwodiktè CYP2J3 ki ogmante CYP2J2 / eets ak PPAR nan selil endothelial venn lonbrit imen (HUVECs) α Ekspresyon Ang II siyifikativman anpeche Ang II pwovoke NF- κ B translokasyon nikleyè, I κ B α Regilasyon desann, Ca2 + intraselilè. surcharge ak aktivasyon nan sitokin proenflamatwa.Ophiopogonin D te itilize pou trete enflamasyon ak maladi kadyovaskilè pou dè milye ane.
Kategori ki enpòtan
Siyal chemen >> transmembrane transpò >> chanèl kalsyòm
Domen rechèch > > maladi kadyovaskilè
Chemen siyal > > sik selil / domaj ADN > > PPAR
Jaden rechèch > > enflamasyon / iminite
Sib
PPARα
NF-κB
Ca2+
Dokiman referans:[1].Wang L, et al.Homo-aro-cholestane, furostane ak spirostane saponin soti nan tubèrkul yo nan Ophiopogonjaponicus.Fitochimi.2017 Apr;136:125-132.
[2].Huang X, et al.Ophiopogonin D ak EET yo amelyore repons enflamatwa Ang II-induit atravè aktive PPARα nan HUVEC yo.Biochem Biophys Res Commun.2017 Out 19;490(2):123-133.
Angle alyas Ophiopogon saponin D
(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside β-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[β-D-xylopyranosyl-(1->3)]-6-deoxy-
(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-hydroxy-2-(((4R,5'R,6R,6aR,6bS,8aS) ,8bR,9S,10R,11aS,12aS,12bS)-4-hydroxy-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a, 6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2 '-piran]-6-yl)oxy)-6-methyl-4-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro- 2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
Ophiopogonin D
Deacetylophiopogonin C
