Cycloastragenol CAS Nọmba 78574-94-4
Nkọwapụta ngwaahịa
[aha]:mmanya cycloastragalus
[utu]:triterpenoid cyclic flavonol
[Aha bekee]:cycloastragenol
[usoro ihe omimi]:C30H50O5
[molecular arọ]:490.71
[CAS Mba]:78574-94-4
[usoro nchọpụta]:HPLC ≥ 98%
[Nkọwa]:20mg 50mg 100mg 500mg 1g (nwere ike ngwugwu dị ka ahịa chọrọ)
[ihe onwunwe]:ngwaahịa a bụ kristal acicular enweghị agba
[ọrụ na ojiji]:A na-eji ngwaahịa a maka ikpebi ọdịnaya, njirimara, nnwale ọgwụ, nyocha ọrụ na nnwale nyocha sayensị ndị ọzọ.Dị ka nchịkwa cell, ule intragastric, nyocha nke ime ụlọ nke ụlọ ọrụ ọgwụ, wdg. Isi mmalite: Astragalus membranaceus (Fisch.) Bge.Mkpokọta mgbọrọgwụ akpọnwụwo
Usoro nchekwa
2-8 Celsius C, mechie site na ọkụ ma chekwaa ya na obere okpomọkụ.
Rịba ama
Ekwesịrị ịchekwa ngwaahịa a na obere okpomọkụ.Ọ bụrụ na ekpughere ya na ikuku ruo ogologo oge, ọdịnaya ga-ebelata.
Ọnọdụ chromatographic} kọlụm chromatographic: Zorbax rx-c18 (4.6mm) × 150mm), 5 μ m ； Akụkụ mkpanaka: mmiri acetonitrile (30:70);Ọsọ ọsọ: 1.0ml/min, okpomọkụ kọlụm: 35 ℃, ELSD parameters: drift tube okpomọkụ: 105 ℃, nitrogen eruba ọnụego: 2.70ml/min.
Njirimara physicochemical: njupụta 1.20
Bioactivity nke cycloastragenol
Cycloastragalol bụ triterpene saponin, nke bụ Astragalus membranaceus (Fisch.) The hydrolyzate nke ihe na-arụ ọrụ na Bunge).Astramembrangenin nwere nchekwa ọnụ ma nwee mmetụta dị iche iche nke ọgwụ, gụnyere ịgbalite telomerase, ịgbatị telomere, mgbochi mkpali na ihe antioxidant.Astramembrangenin nwere ihe mgbochi ịka nká.CAG na-akpali ọrụ telomerase na keratinocytes amụrụ ọhụrụ na mkpụrụ ndụ akwara oke ma na-akpalite CREB.Astramembrangenin nwere ike inwe mmetụta ọgwụgwọ ọhụrụ na ịda mbà n'obi
Otu dị mkpa:
Ụzọ mgbaama > > apoptosis > > apoptosis
Ogige nyocha > > mbufụt / mgbochi
Mpaghara nyocha > > ọrịa akwara ozi
N'ime Vitro Ọmụmụ:
E jiri ya tụnyere njikwa ihe na-ebu na omenala HEK, protein membrane star (0-10 μM; 3-6 ụbọchị) mụbara uto cell [1].Astramembrangenin (0.3 μ M;Nkeji 5-90) kpalitere CREB phosphorylation na neurons cortical bụ isi, yana nkwupụta nke mkpokọta CREB na ụdị sel abụọ ahụ emetụtaghị CAG [1].protein akpụkpọ anụ kpakpando (3) μ M;6-48 awa) nwere ike ịkwalite ntụgharị mgbaàmà vivo na neurons, na-abawanye okwu TERT mRNA, ma gosipụta mmụba bcl 2 mRNA okwu [1].Nnwale viability cell [1] ahịrị cell: Ntinye uche cell HEK: 1 μM，3 μM，10 μM oge omenala: 3-6 ụbọchị pụta: uto cell mụbara okpukpu abụọ na ụbọchị isii.Western blot analysis [1] cell line: neuron cell focus: 0.3 μM omenala oge: nkeji 5, nkeji 15, nkeji 30, nkeji 90.Nsonaazụ: CAG butere CREB n'ime neurons.RT-PCR [1] ahịrị sel: mkpokọta mkpụrụ ndụ neuron: 3 μM oge omenala: nsonaazụ awa 6-48: ngosipụta nke TERT na Bcl 2 mRNA mụbara.
Ntụaka:
[1].Ip FC, et al.Cycloastragenol bụ ike telomerase activator na sel neuronal: ihe ọ pụtara maka njikwa ịda mbà n'obi.Neurosignals.2014;22 (1): 52-63 .
[2].Yu Y, et al.Cycloastragenol: Onye na-achọ akwụkwọ akụkọ na-atọ ụtọ maka ọrịa ndị metụtara afọ.Exp The Med.2018 Sep; 16 (3): 2175-2182 .
[3].Sun C, et al.Cycloastragenol na-eme ka ịgbalite na mbelata mgbasawanye na concanavalin A-induced mouse lymphocyte pan-activation model.Immunopharmacol Immunotoxicol.2017 Jun; 39 (3): 131-139 .
Njirimara physicochemical nke Cycloastragenol
Njupụta:1.2 ± 0.1 g / cm3
Ebe esi mmiri:617.2 ± 55.0 ° C na 760 mmHg
Ebe mgbaze:241.0 ruo 245.0 Celsius C
Usoro ihe omimi:c30h50o5
Arọ molikula:490,715
Ebe mgbari:327.1 ± 31.5 Celsius C
Kpọmkwem oke:490.365814
PSA:90,15000
LogP:3.82
Nrụgide Steam:0.0 ± 4.0 mmHg na 25 Celsius
Ndekọ ntụgharị uche:1.582
Ozi nchekwa Cycloastragenol
Koodu ụgbọ njem nke ngwa ahịa dị ize ndụ: noh maka ụdị ụgbọ njem niile
Nọmba RTECS;GX8265000
Koodu mpaghara:: 2942000000
Ụdị Cycloastragalol
Koodu mpaghara:: 2942000000
Cycloastragalol akwụkwọ
Cycloastragenol bụ ike telomerase activator na sel neuronal: ihe ọ pụtara maka njikwa ịda mbà n'obi.
Neurosignals 22 (1), 52-63, (2014)
Cycloastragenol (CAG) bụ aglycone nke astragaloside IV.Achọpụtara ya na mbụ mgbe a na-enyocha ihe mpụta Astragalus membranaceus maka ihe ndị na-arụ ọrụ nwere ihe mgbochi ịka nká.Ọmụmụ ihe ugbu a de...
Telomerase activator akwụkwọ akụkọ na-egbochi mmebi ngụgụ n'ụdị murine nke fibrosis pulmonary idiopathic.
PLoS ONE 8 (3) , e58423, (2013)
Mpụta nke ọrịa ndị metụtara telomere dysfunction, gụnyere AIDS, aplastic anaemia na pulmonary fibrosis, emewo ka mmasị dị na telomerase activators.Anyị na-akọ njirimara nke n...
Nkwalite ọgwụ ọgwụ sitere na Telomerase nke ọrụ antiviral nke CD8+ T lymphocytes mmadụ.
J. Immunol.181 (10), 7400-6, (2008)
Telomerase reverse na-edegharị DNA telomere na nsọtụ chromosomes linear ma na-akwụsị ịka nká cellular.N'adịghị ka ọtụtụ mkpụrụ ndụ somatic nkịtị, nke na-egosi ntakịrị ma ọ bụ enweghị ọrụ telomerase, immun...
Utu aha Bekee nke Cycloastragalol
9,19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24S)
Astramembrangenin
(3β,6α,9β,16β,20R,24R) -20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24R)
(3β,6α,9β,16β,20R,24S) -20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
Cyclosieversigenin
Cyclogalegigenin
