Ngwaahịa

Nkọwa:Danshensu bụ akụkụ dị irè nke Salvia miltiorrhiza, nke nwere ike mee ka ụzọ mgbaàmà Nrf2 rụọ ọrụ ma chebe usoro obi obi.
Otu ndị emetụtara: ụzọ akara > > autophagy > > autophagy
Ụzọ mgbama>> NF-κ B ụzọ mgbama>> keap1-nrf2
Ogige nyocha > > ọrịa obi
Ngwaahịa eke > > benzoic acid

N'ime Vitro Ọmụmụ:Danshensu (DSS) belatara nke ukwuu ọkwa nke enzymes nrịbama (creatine kinase na lactate dehydrogenase) nke ọpụpụ akwara ọbara na oke infarction myocardial.Nke a nwere ike ịkwalite mgbake nke ọrụ obi mgbe m merụrụ ahụ.DSS nwekwara ọrụ scavenging ROS ma na-akwalite ọrụ nke antioxidants endogenous dị ka SOD, pusi, MDA, GSH-Px na HO-1 site n'ịgbalite ihe nrịbama erythrocyte-2 metụtara ihe 2 (Nrf2) ụzọ akara nke Akt na ERK1 na-arụ ọrụ.2 na nyocha Western blot [2].

Na Ọmụmụ Vivo:nnukwu ọgwụgwọ na otu dose nke Danshensu agbanwebeghị plasma tHcy na oke nwere tHcy nkịtị.N'ụzọ dị iche, Danshensu belatara nke ukwuu tHcy na oke nwere tHcy dị elu.Ọkwa dị elu nke cysteine ​​​​na glutathione mgbe a gwọchara Danshensu na-egosi na mmetụta ya na ibelata tHcy bụ site n'ịbawanye ọrụ nke ụzọ trans vulcanization [1].

Nnwale anụmanụ:A na-agbaze kemịkalụ niile na saline ma e wezụga tolcapone gbazere na saline nwere 20% (V / V) peg 200. N'oge nnwale ahụ, a na-ebu ọnụ oke n'otu abalị wee kenye ya na otu dị iche iche.Mgbe anesthesia ether gasịrị, a na-ewepụ ihe dị ka 200 na orbital sinus μ L ọbara, wee kpochapụ mmanya na-aba n'anya ngwa ngwa ma pịa na owu.A na-anakọta ihe nlele ọbara ozugbo n'ime tubes polypropylene nwere heparin sodium na centrifuged na 5000 g na 5 Celsius C maka nkeji 3.A na-edobe ihe nlele plasma ndị a kwadebere na -20 ℃ ma nyochaa n'ime awa 48.

Ntụaka:[1] YG Cao, et al.Mmetụta bara uru nke danshensu, ihe na-arụ ọrụ nke Salvia miltiorrhiza, na metabolism homocysteine ​​​​site na ụzọ trans-sulphuration na oke.Br J Pharmacol.2009 Jun;157 (3): 482–490 .

[2].Yu J, et al.Danshensu na-echebe obi dịpụrụ adịpụ megide mmerụ ahụ reperfusion ischemia site na ịgbalite akara Akt/ERK1/2/Nrf2.Int J Clin Exp Med.2015 Septemba 15;8 (9): 14793-804 .