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Ngwaahịa

Glycyrrhizin, Liquiritin;Liquiritoside;Likvitamin;Liquiritoside Cas No.551-15-5

Nkọwa dị mkpirikpi:

Glycyrrhizin bụ ihe dị mkpa monomer na-arụ ọrụ nke flavonoids licorice.Ọ nwere ọtụtụ mmetụta ọgwụ, dị ka mgbochi oxidation, mgbochi h IV na ndị ọzọ.Ọ nwere ike igbochi ọnya ọnya nke pyloric ligation guzobere na oke, wee mepụta mgbanwe mgbanwe na ọrịa cancer imeju ascites na oke na Ehrlich ascites mkpụrụ ndụ kansa na ụmụ oke.

Aha bekeeỌgwụ: Liquiritin

Aha aha: Liquiritoside;Likvitamin;Liquiritoside

Nkà mmụta ọgwụ: antioxidant, mgbochi h IV, wdg

Cas No.551-15-5


Nkọwa ngwaahịa

Mkpado ngwaahịa

Okwu mmalite

Glycyrrhizin, nke a makwaara dị ka Liquiritin.Licorice bụ osisi nke Glycyrrhiza na Leguminosae.Mgbọrọgwụ ya na ị ga bụ ahịhịa ndị China na-ahụkarị.

A na-ekesa ọgwụ na Northeast China, Xinjiang, Yunnan, Mongolia Inner, Anhui na ebe ndị ọzọ.Shennong materia medica classic depụtara ya dị ka ọkwa kacha elu, na-ekwu na "ahịhịa a bụ eze ọgwụ niile, ọ dịkwa ole na ole na-adịghị eji ya".Licorice nwere ihe mgbagwoju anya, gụnyere triterpenoids, flavonoids na coumarins.Flavonoids bụ ụdị ihe ndị na-emepụta ihe na-emepụta ihe na-esi na licorice wepụ.Ya ọgwụ kemịkal akụkụ tumadi gụnyere glycyrrhizin, isoglycyrrhizin, glycyrrhizin, isoglycyrrhizin, neoglycyrrhizin, wdg Na-adịbeghị anya, e nwere akụkọ na free radical scavenging, antioxidant, mgbochi cancer na mgbochi mutagenic mmetụta nke licorice flavonoids n'ụlọ na ná mba ọzọ.

ChemicalName:4H-1-Benzopyran-4-otu, 2- [4- (β-D-glucopyranosyloxy) phenyl] -2, 3-dihydro-7-hydroxy-, (S)

PhysicalPakụrụngwa:Monohydrate (itinye ethanol ma ọ bụ mmiri), ebe agbaze: 212 ~ 213 Celsius ℃.

Ihe omume ọgwụ
Nsi: Ọ dịghị
Mmeghachi omume ọjọọ: amaghị
Isi ihe na-emepụta: legume Glycyrrhiza glabra L. mgbọrọgwụ, Glycyrrhiza uralensis Fisch Root.

Mwepụta nke Glycyrrhizin

Ngwọta nke akụrụngwa akụrụngwa licorice
Ngwakọta kemịkalụ nke akụrụngwa licorice dị mgbagwoju anya.Iji nweta mmetụta nkewa ka mma, belata mmetọ nke adịghị ọcha na kọlụm chromatographic nkwadebe, ma melite ọdịnaya nke glycyrrhizin n'ime akụrụngwa injection, a na-eji usoro mmịpụta mee ihe iji mebie ngwa ahụ.Tulee hay 4G nwere nguzo eletrọnịkị wee tinye ya na beaker.Jiri cylinder ihe atụ tụọ mmiri nke 100ml nke ọma ma wụsa ya na beaker maka mgbaze.Ultrasonic maka ihe dị ka nkeji 15, na mgbe niile nwuo na mkpara iko iji mee ngwangwa mgbasa.Mgbe ahụ, tinye beaker n'ime bat nke okpomọkụ 90 ℃ ma kpoo ya maka awa 2, wee kpoo ya maka nzacha.Mgbe ịgbakwunye filtrate n'ime n-butanol solvent ma guzoro ruo ọtụtụ nkeji, ọtụtụ n'ime glycosides na-agbaze na n-butanol solvent, wee mee mmịpụta nke abụọ, wepụ obere glycosides fọdụrụ na mmiri, ma mesịa jikọta ma tinye uche n'ime n- butanol ngwọta enwetara site na nke abụọ mmịpụta maka chromatography na ịdị ọcha.

Ọcha Glycyrrhizin site na Chromatography
Were 10 ml nke ngwaahịa a amịpụtara n'elu dị ka akụrụngwa mapụtara, bido mgbapụta ahụ, tọọ ọnụego erute ya na 25 ml / min, wee weta akụrụngwa n'ime 500 mm site na usoro mkpanaka (methanol: mmiri = 1: 4) × Na a. 40 mm kọlụm nkwadebe, na-anakọta akụkụ dị nta nke ngwaahịa hay glucoside dị ka ọnọdụ kacha elu si dị: a na-achịkọta akụkụ nke mbụ 1 h dị ka akụkụ nke pre adịghị ọcha, wee gbanwee mmiri ahụ.Dịka ọmụmaatụ, saa kọlụm ahụ na ngwakọta nke methanol 50% na mmiri, jikọọ ngwaahịa ahụ kwa nkeji 20, wee tinye karama ngwaahịa ọ bụla na evaporation rotary, wee were 20 µ L maka nyocha chromatographic HPLC, ruo mgbe achọpụtaraghị ebumnuche ọ bụla.Ọnọdụ nchọpụta nke HPLC bụ ndị a: usoro mkpanaka: methanol: mmiri = 3.5: 6.5;Oge nkwụsị: silica gel carbon 18;Kọlụm chromatographic: 450 mm × 4.6 mm; Ọnụego ntinye: 1 ml / min;Ogologo oge nchọpụta: 254nm.Ọdịnaya nke glycyrrhizin na karama nke abụọ bụ nke kachasị elu n'ime ngwaahịa a na-enweta kwa nkeji 20 ọ bụla

Ọcha Glycyrrhizin site na rechromatography
Ebe ọ bụ na ọdịnaya nke glycyrrhizin mgbe emechara chromatographic isi adịghị elu, a na-ahọrọ otu usoro ahụ.Were 10 ml nke ngwaahịa a sachara nke dị n'elu dị ka ngwa ngwa njikere, ọnụego eruba bụ 25 ml / min, wee weta karama ngwaahịa nke abụọ n'ime 500 mm site na usoro mkpanaka (methanol: mmiri = 2: 5) × Na 20 mm } kọlụm chromatographic, na-anakọta distillate nke ngwaahịa hay glycoside dị ka ọnọdụ kacha elu si dị: jikọọ ngwaahịa ahụ kwa nkeji 4, wee tinye karama ngwaahịa ọ bụla na ikuku rotary, wee jiri otu ihe nchọpụta ahụ dị n'elu maka nyocha chromatographic HPLC ruo mgbe enweghị ebumnuche. .Mgbe nyochachara, a chọpụtara na ọdịnaya nke glycyrrhizin na karama nke isii bụ nke kachasị elu n'etiti ngwaahịa ndị a na-enweta na nkeji 4 ọ bụla, nke oge njide bụ 5.898 min dị ka ebumnuche kacha elu, ọdịnaya ruru ihe dịka 40% site na usoro nhazi mpaghara. .

Post Ọgwụgwọ nke Ngwaahịa
A na-ekpochapụ ngwaahịa ahụ anakọtara n'okpuru nrụgide dị ntakịrị na evaporator rotary na 70 ℃.Mgbe ihe mgbaze na-ekpochapụ nke ọma, were obere methanol gbarie ngwaahịa ahụ siri ike na flask dị n'okpuru ala, ma kpochaa n'ime tube ule na okpomọkụ dị n'ime ụlọ ruo mgbe kristal na-acha ọcha pụtara [2].


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