Ophiopogonin D Cas No.945619-74-9
Ophiopogon Saponin D Jeneng
Jeneng Inggris:(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galaktopiranosida
Bioaktivitas Ophiopogon Japonicus Saponin D
katrangan:Ophiopogon D minangka glikosida steroid C29 alami sing diisolasi saka umbi Ophiopogon japonicus.Ophiopogonin D minangka inducer CYP2J3 sing nambah CYP2J2 / eets lan PPAR ing sel endothelial vena umbilical manungsa (HUVECs) α Ekspresi Ang II nyandhet Ang II kanthi signifikan NF- κ B translokasi nuklir, I κ B α Regulasi mudhun, Ca2 intraselular + kakehan lan aktivasi sitokin proinflamasi.Ophiopogonin D wis digunakake kanggo nambani inflamasi lan penyakit kardiovaskular sajrone ewu taun.
Kategori Relevan
Jalur sinyal > > transportasi transmembran > > saluran kalsium
Bidang riset > > penyakit jantung
Jalur sinyal > > siklus sel / karusakan DNA > > PPAR
Bidang riset > > inflamasi/kekebalan
Target
PPARα
NF-kB
Ca2+
Dokumen Referensi:[1].Wang L, et al.Homo-aro-cholestane, furostane lan saponin spirostane saka umbi Ophiopogonjaponicus.Fitokimia.2017 Apr;136:125-132.
[2].Huang X, et al.Ophiopogonin D lan EETs nambah respon inflamasi sing diakibatake Ang II liwat ngaktifake PPARα ing HUVECs.Biochem Biophys Res Commun.2017 Agustus 19; 490 (2): 123-133.
Alias Inggris saka Ophiopogon saponin D
(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside β-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[β-D-xylopyranosyl-(1->3)]-6-deoxy-
(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-hydroxy-2-(((4R,5'R,6R,6aR,6bS,8aS) ,8bR,9S,10R,11aS,12aS,12bS)-4-hydroxy-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a, 6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2 '-pyran]-6-yl)oxy)-6-methyl-4-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro- 2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
Ophiopogonin D
Deasetilofiopogonin C
