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Cycloastragenol CAS No

Description:

Cycloastragalolum, saponin triterpenoidum, maxime obtinetur hydrolysi astragaloside IV.cycloastragalolum solum activator telomerasis hodie invenitur.Potest mora telomere correpta telomerasis augendo.Cycloastragalol anti-canus effectum habere consideratur


Product Detail

Product Tags

Product Specification

[nomen];cycloastragalus alcohol

[alias];triterpenoideus cyclicus flavonol

[nomen Anglicum];cycloastragenol

[Molecular formula];C30H50O5

[pondus hypotheticus]490.71

[CAS No.]:78574-94-4

[ratio deprehendendi]:HPLC ≥ 98%

[specification].20mg 50mg 100mg 500mg 1g (sicut elit potest packaged)

[proprietates]Hoc productum est hyalina acicularis crystal

[munus et usus];Productum hoc adhibitum est ad contentum determinationem, agnitionem, experimentum pharmacologicum, navitatem protegendi et alia experimenta scientifica inquisitionis.Ut cellae administratio, probatio intragastrica, inspectio qualitatis internae officinae pharmaceuticae, etc.Source: Astragalus membranaceus (Fisch.) Bge.Exaruit radix extract

Ratio repono

2-8° C, signatus a luce et temperatus humilis.

Nota

Hoc productum condi debet humilis temperatus.Si diu pateat, contentum reduci.

Condiciones chromatographicae} columna chromatographica: Zorbax rx-c18 (4.6mm) × 150mm) ,5 µ m; Phase mobile: aqua acetonitrile (30:70);Fluunt rate: 1.0ml/min, columna temperatura: 35 ℃, ELSD parametri: fistula calliditate temperatus: 105 , nitrogenium fluens rate: 2.70ml/min.

Proprietates physicae: densitas 1.20

Bioactivity of cycloastragenol

Cycloastragalolus triterpenes saponin compositum est, quod est Astragalus membranaceus (Fisch.) De hydrolyzata ingrediens activae in Bunge).Astramembrangenin salutem oralem habet et effectus pharmacologicos amplis habet, inter activationem telomerasicam, prolongationem telomerei, proprietates anti-inflammatorias et antioxidantas.Astramembrandenin habet proprietates anti-canus.CAG actio telomerasis excitat in keratinocyte nato humano et nervus rat cellas et activationem creb inducit.Astramembrangenin potest habere novum medendi effectum in tristitia

Categoria pertinet:
> > > apoptosis > > apoptosis
Investigationes campi > ​​> inflammatio / immunitas
Investigationes campi > ​​> morbi neurologici

In Vitro Study:
Comparatus cum ferebat potestate in cultura HEK, dapibus stellarum membranarum (0-10 µ M; 3-6 dies) auctum cellae incrementum [1].Astramembrangenin(0.3 μ M;5-90 minuta) phosphorylationem in neuronibus corticalibus primariis inductam CREB, et expressio totalis CREB in utraque specie cellularum a CAG affecta non est.μ M;VI-XLVIII horas) potest vivo signo translationis in neurons promovere, TERT mRNA expressionem augere et augeri bel 2 mRNA expression [1].Cellula viability primordium [1] cellula linea: HEK concentratio cellae: 1 µ M,3 µ M,10 µ M culturae tempus: 3-6 dies consequitur: incrementum cellulae duplicatur ad 6 dies.Western dele analysis [1] cellula linea: cell concentratio neuron: 0.3 µ M tempus culturae: 5 minuta, 15 minuta, 30 minuta, 90 minuta.Proventus: CAG activationem in neurons CREB inductam.RT-PCR [1] cellula linea: cell concentratio neuron: 3 µ M tempus culturae: 6-48 horae eventus: expressio TERT et Bcl 2 mRNA aucta.

Relatio:
[1].Ip FC, et al.Cycloastragenol activator potens in cellis neuronalibus est: implicationes pro tristitia procuratio.Neurosignals.2014; 22 (1): 52-63.
[2].Yu Y, et al.Cycloastragenol: Candidatus novas excitando pro morbis ætatibus associatis.Exp Ther Med.2018 Sep;16(3):2175-2182.
[3].Sol C, et al.Cycloastragenol mediat activum et proliferation suppressionem in concanavalin A-inducta exemplar mus lymphocytae pan-activationis.Immunopharmacol Immunotoxicol.2017 Iun; 39 (3): 131-139.

Physica Proprietatibus Cycloastragenol

Densitas:1.2 ± 0.1 g / cm3

Ferveret:617.2 ± 55.0 ° C at 760 mmHg

Liquescens punctum:241.0 ad 245.0 ° C

Formulae hypotheticae:c30h50o5

Pondus hypotheticum:490.715

Mico punctum:327.1 ± 31.5 ° C

Exige massa;490.365814

PSA:90,15000

LogP:3.82

Vapor pressura:0.0 ± 4.0 mmHg ad 25° C

Index refractivus:1.582

Cycloastragenol Safety Information

Transporto codice periculosa bona: nonh omnibus modis onerariis

RTECS numerus;GX8265000

Consuetudines Codicis: 2942000000

Cycloastragalol Consuetudines

Consuetudines Codicis: 2942000000

Cycloastragalol Literature

Cycloastragenol activator potens in cellis neuronalibus est: implicationes pro tristitia procuratio.

Neurosignals 22 (1), 52-63, (2014)
Cycloastragenol (CAG) aglyconum astragaloside IV.Primum notum est cum Astragalus membranaceus extractionem protegit pro rebus activis cum proprietatibus antiaging.Praesens studium de...
Novus telomerasis activator damnum pulmonis in murini exemplari fibrosis pulmonis idiopathicae supprimit.

PLoS PRIMUM 8(3), e58423, (2013)
Morborum emergentia associata cum dysfunctione telomerei, in AIDS, anemia aplastic et fibrosi pulmonalis, usuram in activatoribus telomerasis confirmavit.identificatio alicuius n... nuntiamus
Telomerase fundatum amplificationem pharmaceuticae functionis antiviralis lymphocytarum humani CD8+T.

J. Immunol.181 (10), 7400-6, (2008)
Telomerase e converse telomere DNA transcribit in fines chromosomatum linearium et senescentes cellulosos retardans.E contra normales cellulas somaticas, quae parvam vel nullam actionem telomerases ostendunt, immunes sunt.

English Alias ​​of Cycloastragalol

9,19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24S)-

Astramembrangenin

(3β,6α,9β,16β,20R,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrolum

19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24R)-

(3β,6α,9β,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrolum

Cyclosieversigenin

Cyclogalegigenin


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