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Descriptio:glucoridin est isoflavana ex glycorrhiza glabra, quae ligare et movere potest PPAR γ， The EC50 valor 6115 um.Glabridin habet antioxidantam, antibacterial, glomerulonephritis anti, diabetem anti-tumorem, anti-inflammatorem, anti osteoporosum, cardiovascularem protege, nervos tuere, radicales liberas et alia functiones scavenge.

Related Categoriae:investigationis campi > ​​> cancer
Signans iter > > cyclum cellum / DNA damnum > > PPAR
Investigationes campi > ​​> inflammatio / immunitas

In Vitro Study:glabridin ligat et operatur PPAR γ， EC50 is 6115 um [1].Glabridin（40,80 μ M) Proliferatio linearum SCC-IX et SAS linearum cellularum inhibita est modo dose et temporis dependens post 24 et 48 horas curationis [2].Glabridin（0-80 µ M) Etiam apoptosin inducit, ducens sub G1 cycli cellularum comprehensionem in SCC-9 et SAS lineas cellulas [2].Glabridin (0,20,40 et 80 μ M) Dose dependenter reducitur Caspase-3,-8 et - 9 et aucta FISSIO PARP, signanter phosphorylating ERK1/2, JNK1/2 et P-38 MAPK in SCC-9.CELLAE [2].

In Vivo Study:glabridinum (50 mg / kg, Padi semel cotidie) validam anti-inflammatoriam actionem ostendit et mutationes inflammatorias a dextrano sodium sulfatis (DSS) inductas emendavit.

Notae:[1] Rebhun JF, et al.Identification of glabridin as a bioactive compound in licorice (Glycyrrhiza glabra L.Fitoterapia.2015 Oct;106:55-61.
[2].Chen CT, et al.Glabridin inducit apoptosin et cyclum cellularum comprehensionem in cellulis cancri oralis per iter JNK1/2 significans.Environ Toxicol.2018 Jun;33 (6): 679-685.
[3].El-Ashmawy NE, et al.downregulation of inos and elevation of camp mediae the anti-inflammatory effect of glabridin in mures with ulcerative colitis.Inflammopharmacologia.MMXVIII Apr;26(2):551-559.