Acidum Salvianolicum C
Propositum
Acidum Salvianolicum C inhibitor cytochromi p4502c8 (cyp2c8) non competitive est et inhibitor mixti cytochromi P4502J2 (CYP2J2) cum media vehementia.Eius valores Ki pro cyp2c8 et CYP2J2 sunt 4.82 respective μ M et 5.75 µ M
Nomen anglicum
(2R) -3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)- 7-hydroxy-1-benzofuran-4-yl]-2- propenoyl} oxy) propanoicum acidum
Anglicus Alias
(2R) -3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2 -enoyl}oxy) acidum propanoicum
(2R) -3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]-2- propenoyl} oxy) propanoicum acidum
Acidum benzenepropanoicum, α-[[(2E)-3-[2-(3,4-dihydroxyphenyl) -7-hydroxy-4-benzofuranyl] -1-oxo-2-propen-1-yl]oxy]-3; 4-dihydroxy-, (αR)-
Acidum Salvianolicum C
De Proprietatibus Physicochemicis Acidum Salvianolicum C
Densitas: 1.6 ± 0.1 g / cm3
Fervens Point: 844.2 ± 65.0 ° C ad 760 mmHg
Formulae hypotheticae: C26H20O10
Pondus hypotheticum: 492.431
Mico punctum: 464.4 ± 34.3 ° C
Exacta Missa: 492.105652
PSA:177.89000
LogP: 3.12
Vapor Pressura: 0.0 ± 3.3 mmHg ad 25° C
Index refractivus: 1.752
Bioactivity De Salvianolic Acido C
Descriptio:
Acidum Salvianolicum C inhibitor cytochromi p4502c8 (cyp2c8) non competitive est et inhibitor mixti cytochromi P4502J2 (CYP2J2) cum media vehementia.Eius valores Ki pro cyp2c8 et CYP2J2 sunt 4.82 µ M et 5.75 µ M。
Genera pertinentia:
P450 . > > metabolic enzyme / protease > > cytochrome P450
Investigatio campi > > cancer
Natural Products >> alii
Scopum:
CYP2C8:4.82 μM (Ki)
CYP2J2:5.75 μM (Ki)
In Vitro Study:
Acidum Salvianolicum C est moderatum inhibitor mixti inhibitoris non competitive cyp2c8 inhibitoris et CYP2J2.KIS cyp2c8 et CYP2J2 sunt 4.82 et 5.75, respective μ M[1]。 1 et 5 µ M acidum salvianolicum C (SALC) signanter inhibere LPS nullam productionem adduci potest.Acidum Salvianolicum C expressionem iNOS significanter reduxit.Acidum Salvianolicum C vetat LPS inductum TNF- α， IL-1 β， IL-6, IL-X superductae sunt.Acidum Salvianolicum C stringit LPS inductum NF- κ B activum.Acidum Salvianolicum C etiam expressionem Nrf2 et HO-1 in BV2 microglia auxit.
In Vivo Studiorum:
Acidum Salvianolicum C (20mg / kg) curatio significanter evasionem latency redegit.Praeterea SALC (10 et 20 mg / kg) tractatum signanter augevit numerum transitus suggesti comparati cum exemplari coetus LPS.Comparata cum exemplarium circulo, systemica administrationis acidi salvianolici C descendentis cerebri regularis TNF- α， IL-1 β Et IL-6 gradus.Gradus iNOS et COX-2 in cerebri cortex et hippocampi mures altiores erant quam qui in globo moderante, cum curatio salvianolicum C cortex et hippocampi signanter descendens moderabatur.Acidum Salvianolicum C (5, 10 et 20 mg / kg) auctum curationis p-ampk, Nrf2, HO-1 et NQO1 gradus in rat cerebri cortex et hippocampus in modo dependens [2].
Relatio:
[1].Xu MJ, et al.Effectus inhibitoriae Danshen componentium in CYP2C8 et CYP2J2.Chem Biol Interact.2018 Jun 1;289: 15-22.
[2].Song J, et al.Activatio Nrf2 significativa per acidum salvianolicum C attenuat NF κ B responsio inflammatoria mediata tam vivo quam in vitro.Int Immunopharmacol.MMXVIII Oct;63:299-310.
