page_head_bg

Products

Methylophiopogonanone A; Opogonanone A

Short Description:

Common Name: Ophiopogon japonicus high isoflavone a

English Name: methylophiopogonnone a

CAS No.: 74805-92-8

Molecular Weight: 342.343

Density: 1.4 ± 0.1 g / cm3

Boiling Point: 580.1 ± 50.0 ° C at 760 mmHg

Molecular Formula: c19h18o6

Melting Point: N/ A

MSDS: N/ A

Flash Point: 212.9 ± 23.6 ° C


Product Detail

Product Tags

Application of Methylophiopogonanone A

Methylophiopogonanone A is a flavonoid extracted from Ophiopogon japonicas, which has antioxidant and anti-inflammatory effects.

Name Of Methylophiopogonanone A

English Name:
(3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one

Chinese Alias:
Ophiopogon methyl flavanone a | methyl Ophiopogon dihydrohomoisoflavone a | methyl Ophiopogon flavanone a

Biological Activity Of Methylophiopogonanone A

Description: methylophiopogonanone A is a flavonoid extracted from Ophiopogon japonicas, which has
antioxidant and anti-inflammatory effects.
Related Categories: signal pathway > > apoptosis > > apoptosis
research field > > inflammation / immunity

In Vitro Study: methyl aspartate a (mo-a; 10 μ Mo (L / L) significantly decreased apoptosis and Caspase-3 expression, increased Bcl-2 / Bax ratio and restored no production. Methylaspartate a (mo-a) pretreatment

significantly enhanced the activation of PI3K / Akt / eNOS pathway in H9c2 cells under H / R, while the protective effect of mo-a was cancelled in the presence of PI3K inhibitor wortmannin (100 nmol / L) [1].

In Vivo Study: protective effect of methylaspartate a (mo-a; 10mg / kg / D, PO) on cardiac function after myocardial I / R injury [1].

References: [1] He F, et al. Methylophiopogonanone A suppresses ischemia/reperfusion-induced myocardial apoptosis in mice via activating PI3K/Akt/eNOS signaling pathway. Acta Pharmacol Sin. 2016 Jun; 37(6):763-71.

Physicochemical properties Of Methylophiopogonanone A

Density: 1.4 ± 0.1 g / cm3

Boiling Point: 580.1 ± 50.0 ° C at 760 mmHg

Molecular Formula: c19h18o6

Molecular Weight: 342.343

Flash Point: 212.9 ± 23.6 ° C

Exact Mass: 342.110352

PSA:85.22000

LogP:5.16

Steam Pressure: 0.0 ± 1.7 mmHg at 25 ° C

Refractive Index: 1.654

English Alias Of Methylophiopogonanone A

(1,3-Benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydro-4H-chromen-4-one

4H-1-Benzopyran-4-one, 3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-

N1002

Methylophiopogonanone A

Yongjian Service

Customized Service Of Chemical Reference Materials Of Traditional Chinese Medicine
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd. is mainly engaged in the basic research of active substances of traditional Chinese medicine for more than ten years. So far, the company has conducted in-depth research on more than 100 kinds of commonly used traditional Chinese medicine, and extracted thousands of chemical components.

The company has top R & D personnel and perfect testing and analysis equipment in the industry, and has served hundreds of scientific research institutions. It can quickly and efficiently meet the needs of customers

Drug Impurity Separation, Preparation and Structure Confirmation Service
Impurities in drugs are closely related to the quality, safety and stability of drugs. The preparation and structure confirmation of impurities in drugs can help us understand the ways of impurities and provide a basis for the improvement of production process. Therefore, the preparation and separation of impurities is of great significance to drug research and development.

However, the content of impurities in the drug is low, the source is wide, and the structure is mostly similar to the principal component. What technology can be used to separate and purify all impurities in the drug one by one and quickly? What techniques and methods are used to confirm the structure of these impurities? This is the difficulty and challenge faced by many pharmaceutical units, especially the pharmaceutical enterprises of plant medicine and Chinese patent medicine.

Based on such needs, the company has launched drug impurity separation and purification services. Relying on nuclear magnetic resonance, mass spectrometry and other equipment and technologies, the company can quickly identify the structure of the separated compounds, so as to meet the needs of customers.

SPF Animal Experiment
The construction area of the animal experimental area is 1500 square meters, including 400 square meters of SPF level experimental area and 100 square meters of P2 level cell laboratory. Led by scientists of China Pharmaceutical University, it forms a core technical team with a number of returnees. Provide high-quality animal models, experimental design, overall projects and other services for biomedical scientific research, teaching and industrial development.

Scope Of Business

1. Small animal feeding

2. Animal disease modeling

3. College project outsourcing

4. Pharmacodynamic evaluation in vivo

5. Pharmacokinetic evaluation

6. Tumor cell experiment service

Our Strengths

1. Focus on real experiments

2. Strictly standardize the process

3. Strictly sign confidentiality agreement

4. Own laboratory without intermediate links

5. The professional technical team guarantees the experimental quality

SPF experimental environment, specially assigned person feeding, real-time tracking experimental progress


  • Previous:
  • Next:

  • Write your message here and send it to us