Zogulitsa

Chlorogenic acid imakhala ndi zinthu zambiri zachilengedwe.Kafukufuku wokhudzana ndi chilengedwe cha chlorogenic acid mu sayansi yamakono apita mozama m'madera ambiri, monga chakudya, chisamaliro chaumoyo, mankhwala, makampani opanga mankhwala tsiku ndi tsiku ndi zina zotero.Chlorogenic acid ndi chinthu chofunikira kwambiri cha bioactive, chomwe chili ndi ntchito za antibacterial, antiviral, kuwonjezeka kwa leukocyte, kuteteza chiwindi ndi ndulu, anti-chotupa, kutsitsa kuthamanga kwa magazi, kutsitsa lipids zamagazi, kuwononga ma radicals aulere komanso kusangalatsa kwapakati pamanjenje.

Antibacterial ndi antiviral
Eucommia ulmoides chlorogenic asidi ali amphamvu antibacterial ndi odana ndi kutupa zotsatira, aucubin ndi ma polima ndi zoonekeratu antibacterial zotsatira, ndi aucubin ali chopinga zotsatira pa Gram-negative ndi zabwino mabakiteriya.Aucubin imakhala ndi bacteriostatic ndi diuretic zotsatira, ndipo imatha kulimbikitsa machiritso a bala;Aucubin ndi glucoside amathanso kupanga zodziwikiratu sapha mavairasi oyambitsa zotsatira pambuyo chisanadze chikhalidwe, koma alibe sapha mavairasi oyambitsa ntchito.Institute of aging Medical Sciences, Aichi Medical University, yatsimikizira kuti zinthu zamchere zotengedwa ku Eucommia ulmoides Oliv.Ali ndi mphamvu yowononga chitetezo cha mthupi cha munthu.Mankhwalawa atha kugwiritsidwa ntchito popewa komanso kuchiza Edzi.

Antioxidation
Chlorogenic acid ndi othandiza phenolic antioxidant.Mphamvu yake ya antioxidant ndi yamphamvu kuposa caffeic acid, p-hydroxybenzoic acid, ferulic acid, syringic acid, butyl hydroxyanisole (BHA) ndi tocopherol.Chlorogenic asidi ali antioxidant kwenikweni chifukwa lili ndi kuchuluka kwa R-OH kwakukulu, amene akhoza kupanga hydrogen kwakukulukulu ndi antioxidant kwenikweni, kuti athetse ntchito ya hydroxyl kwambiri, superoxide anion ndi zina free ankafuna kusintha zinthu mopitirira, kuti ateteze minofu ku okosijeni. kuwonongeka.

Free radical scavenging, anti-kukalamba, anti-musculoskeletal kukalamba
Chlorogenic acid ndi zotumphukira zake zimakhala ndi mphamvu zowononga kwambiri kuposa ascorbic acid, caffeic acid ndi tocopherol (vitamini E), zimatha kuwononga DPPH yaulere, hydroxyl free radical and superoxide anion free radical, komanso imatha kuletsa makutidwe ndi okosijeni otsika kachulukidwe. lipoprotein.Chlorogenic acid imatenga gawo lofunikira pakuchotsa bwino ma radicals aulere, kusunga mawonekedwe ndi magwiridwe antchito a maselo amthupi, kupewa ndikuchedwetsa kusinthika kwa chotupa ndi kukalamba.Eucommia chlorogenic acid ili ndi gawo lapadera lomwe lingalimbikitse kaphatikizidwe ndi kuwonongeka kwa kolajeni pakhungu la munthu, fupa ndi minofu.Imakhala ndi ntchito yolimbikitsa metabolism ndikuletsa kuchepa.Angagwiritsidwe ntchito kupewa kuchepa kwa mafupa ndi minofu chifukwa cha kulemera kwa danga.Nthawi yomweyo, zimapezeka kuti Eucommia chlorogenic acid imakhala ndi anti free radical effect mu vivo ndi mu vitro.

Kuletsa kusintha kwa masinthidwe ndi antitumor
Kuyesera kwamakono kwamankhwala kwatsimikizira kuti Eucommia ulmoides chlorogenic acid ali ndi zotsatira za anti-cancer ndi anti-cancer.Akatswiri a ku Japan aphunzira za antimutagenicity ya Eucommia ulmoides chlorogenic acid ndipo adapeza kuti izi zikugwirizana ndi zigawo za anti mutagenic monga chlorogenic acid, kuwulula kufunikira kwa chlorogenic acid popewa chotupa.
Ma polyphenols mu masamba ndi zipatso, monga chlorogenic acid ndi caffeic acid, amatha kuletsa mutagenicity wa carcinogens aflatoxin B1 ndi benzo [a] - pyrene poletsa ma enzymes omwe adatsegulidwa;Chlorogenic acid imathanso kukwaniritsa zotsutsana ndi khansa komanso zotsutsana ndi khansa pochepetsa kugwiritsa ntchito ma carcinogens ndi kayendedwe kake m'chiwindi.Chlorogenic acid imakhala ndi zotsatira zoletsa kwambiri pa khansa yapakhungu, khansa ya chiwindi ndi khansa ya m'mphuno.Amaonedwa kuti ndi othandiza kwambiri poteteza khansa ku khansa.

Chitetezo kwambiri pamtima dongosolo
Monga free radical scavenger ndi antioxidant, chlorogenic acid yatsimikiziridwa ndi kuyesa kwakukulu.Izi kwachilengedwenso ntchito chlorogenic asidi akhoza kuteteza dongosolo mtima.Isochlorogenic acid B imakhudza kwambiri kulimbikitsa kutulutsidwa kwa prostacyclin (PGI2) ndi anti-platelet aggregation mu makoswe;Mlingo woletsa wa SRS-A kutulutsidwa koyambitsidwa ndi antibody kupita ku zinyalala za m'mapapo a Guinea pig anali 62.3%.Isochlorogenic acid C idalimbikitsanso kutulutsidwa kwa PGI2.Kuphatikiza apo, isochlorogenic acid B imakhala ndi mphamvu yoletsa kuphatikizika kwa mapulateleti a thromboxane biosynthesis ndi kuvulala kwa endothelin komwe kumabwera chifukwa cha hydrogen peroxide.

Hypotensive zotsatira
Zatsimikiziridwa ndi zaka zambiri zamayesero azachipatala kuti Eucommia chlorogenic acid imakhala ndi antihypertensive kwenikweni, yokhazikika yochiritsa, yopanda poizoni komanso yopanda zotsatirapo.The University of Wisconsin anapeza kuti ogwira zigawo zikuluzikulu za Eucommia ulmoides wobiriwira kuchepetsa kuthamanga kwa magazi ndi terpineol diglucoside, aucubin, asidi chlorogenic, ndi Eucommia ulmoides chlorogenic asidi polysaccharides.[5]

Ntchito zina zamoyo
Chifukwa chlorogenic acid imakhala ndi choletsa chapadera pa hyaluronic acid (HAase) ndi glucose-6-phosphatase (gl-6-pase), chlorogenic acid imakhudzanso machiritso a bala, thanzi la khungu ndi kunyowetsa, kudzoza mafupa, kuteteza kutupa ndi kutupa. kuwongolera bwino kwa glucose m'magazi.Chlorogenic acid imakhala ndi zoletsa zolimba komanso zopha pa matenda osiyanasiyana ndi ma virus.Chlorogenic acid imakhala ndi zotsatira za pharmacological zochepetsera kuthamanga kwa magazi, antibacterial, antiviral, anti-yotupa, kuwonjezera maselo oyera a magazi, kupewa matenda a shuga, kuchulukitsa m'mimba motility komanso kulimbikitsa kutulutsa kwam'mimba.Kafukufuku wasonyeza kuti oral chlorogenic acid akhoza kwambiri yotithandiza katulutsidwe ya ndulu ndi zotsatira kupindula ndulu ndi kuteteza chiwindi;Ikhozanso kulepheretsa hemolysis ya makoswe erythrocytes chifukwa cha H2O2.