Zogulitsa

Kufotokozera:Danshensu ndi gawo lothandiza la Salvia miltiorrhiza, lomwe limatha kuyambitsa njira yolumikizira ya Nrf2 ndikuteteza dongosolo la mtima.
Magulu Ofananira: njira yolumikizira>> autophagy>> autophagy
Njira yolumikizira>> NF- κ B njira yolumikizira>> keap1-nrf2
Kafukufuku > > matenda a mtima
Natural Products > > benzoic zidulo

Phunziro la In Vitro:Danshensu (DSS) inachepetsa kwambiri milingo ya ma enzymes (creatine kinase ndi lactate dehydrogenase) ya coronary outflow ndi kukula kwa myocardial infarction.Izi zitha kulimbikitsa kuyambiranso kwa mtima pambuyo povulala kwa I / R.DSS ilinso ndi ntchito yowononga ya ROS ndipo imalimbikitsa ntchito ya antioxidants endogenous monga SOD, mphaka, MDA, GSH-Px ndi HO-1 poyambitsa nyukiliya factor erythrocyte-2 yokhudzana ndi chinthu 2 (Nrf2) njira yowonetsera yomwe imakhala pakati pa Akt ndi ERK1.2 mu Western blot analysis [2].

Mu Phunziro la Vivo:pachimake mankhwala ndi limodzi mlingo wa Danshensu sanasinthe plasma tHcy makoswe ndi yachibadwa tHcy.Mosiyana ndi zimenezi, Danshensu anachepetsa kwambiri tHcy mu makoswe okhala ndi tHcy yokwezeka.Kuchuluka kwa cysteine ​​​​ndi glutathione pambuyo pa chithandizo ndi Danshensu kumasonyeza kuti zotsatira zake zochepetsera tHcy ndikuwonjezera ntchito ya trans vulcanization pathway [1].

Kuyesera kwa Zinyama:mankhwala onse amasungunuka mu saline kupatula tolcapone yosungunuka mu saline yomwe ili ndi 20% (V / V) chikhomo cha 200. Panthawi yoyesera, makoswe anasala kudya usiku wonse ndipo mwachisawawa anapatsidwa magulu osiyanasiyana.Pambuyo pa opaleshoni ya ether, pafupifupi 200 adachotsedwa ku orbital sinus μ L magazi, ndiye mwamsanga mankhwala ophera tizilombo ndi mowa ndikusindikiza ndi thonje.Zitsanzo za magazi nthawi yomweyo anasonkhanitsidwa mu polypropylene machubu munali heparin sodium ndi centrifuged pa 5000 ga pa 5 ° C kwa mphindi 3.Zitsanzo za plasma zokonzedwa zidasungidwa pa -20 ℃ ndikuwunikidwa mkati mwa maola 48.

Zolozera:[1] YG Cao, et al.Zotsatira zabwino za danshensu, gawo logwira ntchito la Salvia miltiorrhiza, pa homocysteine ​​metabolism kudzera mu trans-sulphuration pathway mu makoswe.Br J Pharmacol.2009 Jun;157(3): 482–490.

[2].Yu J, ndi al.Danshensu amateteza mtima wakutali kuvulazidwa kwa ischemia reperfusion kudzera pakuyambitsa chizindikiro cha Akt/ERK1/2/Nrf2.Int J Clin Exp Med.2015 Sep 15;8(9):14793-804.