Isoliquiritin Apioside
Kugwiritsa ntchito Isoliquiritin Apioside
Isoliquiritin apioside, chigawo chodzipatula ku glycorrhizae radio rhome, chinachepetsa kwambiri PMA yomwe inachititsa kuwonjezeka kwa ntchito ya MMP9 ndipo inaletsa PMA inachititsa MAPK ndi NF- κ B kutsegula.Isoliquitin apioside imalepheretsa kuwukira ndi angiogenesis ya ma cell a khansa ndi ma endothelial cell.
Dzina la Isoliquiritin Apioside
Dzina lachi China:Isoliquiritin Apioside
Dzina la Chingerezi:(E) -3- [4- [(2S,3R,4S,5S,6R)-3- [(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl] oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
Bioactivity ya Isoliquiritin Apioside
Kufotokozera:isoliquitin apioside, chigawo chodzipatula ku glycorrhizae radio rhome, chinachepetsa kwambiri PMA yomwe inachititsa kuwonjezeka kwa ntchito ya MMP9 ndipo inalepheretsa PMA inachititsa MAPK ndi NF- κ B kutsegula.Isoliquitin apioside imalepheretsa kuwukira ndi angiogenesis ya ma cell a khansa ndi ma endothelial cell.
ZogwirizanaCmagulu:kafukufuku > > khansa
Njira yolumikizira>> MAPK / ERK njira yolumikizira>> p38 MAPK
Njira yolumikizira>> metabolic enzyme / proteinase>> MMP
Zolinga:MMP9
NF-kB
p38 MAPK
Maphunziro a in vitro:Isorlicin imatha kuletsa bwino ntchito ya gelation MMP-9 ya PMA yochititsa ma cell a HT1080.Isoglycyrrhizin apigenin imachepetsa kuchuluka kwa kupanga MMP-9 m'maselo a HT1080 opangidwa ndi PMA, ili ndi mphamvu ya anti metastasis ndi anti angiogenesis m'maselo owopsa a chotupa ndi ma endothelial cell, ndipo alibe cytotoxicity [1].
Zolozera:[1].Kim A1, ndi al.Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells.Front Pharmacol.2018 Dec 10; 9:1455.
Physicochemical katundu wa Isoliquiritin Apioside
Kachulukidwe: 1.6 ± 0.1 g / cm3
Malo otentha: 901.0 ± 65.0 ° C pa 760 mmHg
Chilinganizo cha maselo: c26h30o13
Kulemera kwa molekyulu: 550.509
Pothirira: 301.9 ± 27.8 ° C
Kulemera kwake: 550.168640
PSA: 215.83000
Chizindikiro: 1.96
Kuthamanga kwa nthunzi: 0.0 ± 0.3 mmHg pa 25 ° C
Mlozera wowonetsa: 1.709
English dzina la Isoliquiritin Apioside
2-Propen-1-imodzi,1-(2,4-dihydroxyphenyl) -3--[4--[[2-O-[(2S,3R,4R))-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl )-2-furanyl]-β-D-glucopyranosyl]oxy]phenyl]-, (2E)-
3-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl]phenyl 2-O-[(2S,3R,4R)-3,4-dihydroxy-4 -(hydroxymethyl)tetrahydro-2-furanyl]-β-D-glucopyranoside
Neolicuroside