Salvianolic acid C
Cholinga
Salvianolic acid C ndi inhibitor yosapikisana ya cytochrome p4502c8 (cyp2c8) komanso inhibitor yosakanikirana ya cytochrome P4502J2 (CYP2J2) yokhala ndi mphamvu yapakatikati.Miyezo yake ya Ki pa cyp2c8 ndi CYP2J2 ndi 4.82 motsatana μ M ndi 5.75 μ M
Dzina lachingerezi
(2R) -3-(3,4-Dihydroxyphenyl) -2-({(2E)-3--[2-(3,4-dihydroxyphenyl)- 7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy) propanoic acid
English Alias
(2R) -3-(3,4-Dihydroxyphenyl) -2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2 -enoyl}oxy) propanoic acid
(2R) -3-(3,4-Dihydroxyphenyl) -2-({(2E)-3--[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy) propanoic acid
Benzenepropanoic acid, α--[[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3, 4-dihydroxy-, (αR)-
Salvianolic acid C
Physicochemical katundu wa Salvianolic Acid C
Kachulukidwe: 1.6 ± 0.1 g / cm3
Malo Owira: 844.2 ± 65.0 ° C pa 760 mmHg
Fomula ya mamolekyu: C26H20O10
Kulemera kwa Maselo: 492.431
Pothirira: 464.4 ± 34.3 ° C
Misa Yeniyeni: 492.105652
PSA: 177.89000
Mtundu: 3.12
Kuthamanga kwa Steam: 0.0 ± 3.3 mmHg pa 25 ° C
Mlozera wowoneka bwino: 1.752
Bioactivity ya Salvianolic Acid C
Kufotokozera:
Salvianolic acid C ndi inhibitor yosapikisana ya cytochrome p4502c8 (cyp2c8) komanso inhibitor yosakanikirana ya cytochrome P4502J2 (CYP2J2) yokhala ndi mphamvu yapakatikati.Makhalidwe ake a Ki a cyp2c8 ndi CYP2J2 ndi 4.82 motsatana μ M ndi 5.75 μ M.
Magawo oyenera:
Njira yolumikizira>> metabolic enzyme/protease>> cytochrome P450
Kafukufuku> > khansa
Natural Products > > ena
Zolinga:
CYP2C8:4.82 μM (Ki)
CYP2J2:5.75 μM (Ki)
Phunziro la In Vitro:
Salvianolic acid C ndi choletsa chosakanikirana chosakanikirana cha cyp2c8 inhibitor ndi CYP2J2.The KIS ya cyp2c8 ndi CYP2J2 ndi 4.82 ndi 5.75 motsatira μ M [1]. 1 ndi 5 μ M salvianolic acid C (SALC) ikhoza kuletsa kwambiri LPS yomwe imapangitsa kuti pasakhale kupanga.Salvianolic acid C idachepetsa kwambiri mawu a iNOS.Salvianolic acid C imalepheretsa LPS yomwe inachititsa kuti TNF- α, IL-1 β, IL-6 ndi IL-10 ikhale yochuluka.Salvianolic acid C imalepheretsa LPS kuyambitsa NF- κ B.Salvianolic acid C idakulitsanso mawu a Nrf2 ndi HO-1 mu BV2 microglia [2].
Mu Maphunziro a Vivo:
Chithandizo cha Salvianolic acid C (20mg/kg) chinachepetsa kwambiri kuthawa kwachedwa.Kuphatikiza apo, chithandizo cha SALC (10 ndi 20 mg / kg) chinachulukitsa kwambiri kuchuluka kwamawoloka nsanja poyerekeza ndi gulu lachitsanzo la LPS.Poyerekeza ndi gulu lachitsanzo, kayendetsedwe ka kayendetsedwe ka salvianolic acid C pansi pa ubongo TNF- α, IL-1 β Ndi IL-6.Miyezo ya iNOS ndi COX-2 mu cerebral cortex ndi hippocampus ya makoswe inali yapamwamba kuposa ya gulu lolamulira, pamene chithandizo cha salvianolic acid C chinayang'anira cortex ndi hippocampus.Salvianolic acid C (5, 10 ndi 20 mg / kg) chithandizo chinawonjezeka p-ampk, Nrf2, HO-1 ndi NQO1 misinkhu mu makoswe cerebral cortex ndi hippocampus m'njira yodalira mlingo [2].
Zolozera:
[1].Xu MJ, et al.Zotsatira Zoletsa za Danshen components pa CYP2C8 ndi CYP2J2.Chem Biol Interact.2018 Jun 1;289:15-22 .
[2].Song J, ndi al.Kutsegula kwa chizindikiro cha Nrf2 ndi salvianolic acid C kumalepheretsa NF κ B kuyankha kwapakati pa kutupa mu vivo ndi mu vitro.Mankhwala a Immunopharmacol.Oct 2018;63:299-310.
