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Zogulitsa

Verbascoside CAS No. 61276-17-3

Kufotokozera Kwachidule:

Verbascoside ndi mankhwala omwe ali ndi formula ya C29H36O15.

Dzina lachi China:Verbascoside English dzina: acteoside;Verbascoside;Kusaginin

Dzinali:ergosterol ndi Mullein Molecular Formula: C29H36O15


Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Zambiri Zofunikira

[dzina]Mullein glycoside

[zina]ergosterol, Mullein

[gulu]phenylpropanoid glycosides

[Dzina lachingerezi]acteoside;Verbascoside;Kusaginin

[chilinganizo cha maselo]C29H36O15

[kulemera kwa maselo]624.59

[CAS No.]61276-17-3

Physicochemical Properties

[katundu]mankhwalawa ndi woyera singano kristalo ufa

[kachulukidwe wachibale]1.6g/cm3

[kusungunuka]amasungunuka mosavuta mu ethanol, methanol ndi ethyl acetate.

M'zigawo Gwero

Izi ndi tsinde louma lomwe lili ndi masamba owuma a Cistanche deserticola, chomera cha banja la liedang.

Njira Yoyesera

HPLC ≥ 98%

Chromatographic mikhalidwe: mobile phase methanol acetonitrile 1% acetic acid (15:10:75), kuthamanga kwa 0.6 ml · min-1, kutentha kwapakati 30 ℃, kutalika kwa mawonekedwe 334 nm (zongotchula chabe)

Ntchito ndi Kugwiritsa Ntchito

Izi zimagwiritsidwa ntchito pozindikira zomwe zili

Njira Yosungira

2-8 ° C, kusungidwa kutali ndi kuwala.

Bioactivity ya Verbascoside

Phunziro la In Vitro:

Monga mpikisano wa PKC Inhibitor wa ATP, Verbascoside ili ndi IC50 ya 25 μ M [1]。 Verbascoside (5,10) μ M) Kuletsa kwa 2,4-dinitrochlorobenzene (DNCB) - kuchititsa T cell costimulatory factor CD86 ndi CD54, proinflammatory cytokines ndi NF mu maselo a thk-1 κ B njira yotsegula [2].

Mu Maphunziro a Vivo:

Verbascoside (1%) inachepetsa kuchuluka kwa machitidwe okanda komanso kuopsa kwa zotupa pakhungu mumtundu wa mbewa wa 2,4-dinitrochlorobenzene (DNCB) - induced atopic dermatitis (AD).Verbascoside imathanso kuletsa pro-inflammatory cytokine TNF mu DNCB imayambitsa zotupa pakhungu- α, Kufotokozera kwa IL-6 ndi IL-4 mRNA [2].Verbascoside (50100 mg / kg, IP) sinasinthe kuzizira koopsa kwa ululu wobwera chifukwa cha kuvulala kosalekeza (CCI).Verbascoside (200 mg / kg, IP) inachepetsa kusagwirizana ndi kuzizira komwe kunayambitsa acetone pa tsiku la 3. Verbascoside inachepetsanso kwambiri kusintha kwa khalidwe lokhudzana ndi matenda a ubongo.Kuphatikiza apo, Verbascoside inachepetsa Bax ndikuwonjezera Bcl-2 pa tsiku 3 [3].

Kuyesa Maselo:

lymphocytic mouse leukemia L1210 cell (ATCC, CCL 219) inali ndi 10% fetal bovine serum, 4 mmM glutamine, 100 U / ml penicillin, 100 μ Mu 24 chitsime cha tsango mbale ya Dulbecco kusinthidwa Chiwombankhanga sing'anga, maselo 104 pa chitsime anali ochepa Ml streptomycin sulfate ndi Verbascoside (kusungunuka mu DMSO).Kukula kunayang'aniridwa powerengera kuchuluka kwa ma cell mu kauntala ya Coulter pambuyo pa masiku a 2 akukulitsidwa mumlengalenga wonyowa (5% CO2 mumpweya) pa 37 ℃.Mtengo wa IC50 unawerengedwa kutengera mzere wodutsa mzere womwe umakhazikitsidwa pagawo lililonse loyesa [1].

Kuyesera kwa Zinyama:

Pofuna kuyambitsa atopic dermatitis (AD) - monga zizindikiro, makoswe [2] amagwiritsa ntchito 2,4-dinitrochlorobenzene (DNCB).Mwachidule, tsitsi la mbewa la mbewa linachotsedwa ndi lumo lamagetsi 2 masiku asanalandire chithandizo cha DNCB.Will 200 μ L wa 1% DNCB (mu acetone: mafuta a azitona = 4: 1) adagwiritsidwa ntchito pakhungu lakumbuyo lometedwa kuti lidziwitse.Kuwukira mobwerezabwereza kunachitika pamalo omwewo, 0.2% DNCB masiku atatu aliwonse kwa masabata a 2.Mbewa zinagawidwa m'magulu a 4 (n = 6 mu gulu lirilonse): (1) kuyendetsa galimoto, (2) DNCB kuthandizidwa kokha, (3) 1% Verbascoside (acetone: mafuta a azitona 4: 1) - mankhwala okha, ndi ( 4) DNCB + 1% gulu la Verbascoside [2].

Zolozera:

[1].Herbert JM, et al.Verbascoside yolekanitsidwa ndi Lantana camara, inhibitor ya protein kinase C. J Nat Prod.1991 Nov-Dec; 54 (6): 1595-600.

[2].Li Y, ndi al.Verbascoside Imachepetsa Zizindikiro za Atopic Dermatitis mu Mbewa kudzera pa Mphamvu Yake Yotsutsa-Kutupa.Int Arch Allergy Immunol.2018;175(4):220-230.

[3].Amin B, ndi al.Zotsatira za Verbascoside mu Neuropathic Pain Yoyambitsidwa ndi Chronic Constriction Injury mu Makoswe.Phytother Res.2016 Jan; 30 (1): 128-35.


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