Use of Obtusin
Obtusin, from cassia seed, is a highly selective and competitive inhibitor of human monoamine oxidase-A (hmao-a), with an IC50 of 11.12 μ M. Ki is 6.15. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression.
Name of Obtusin
English Name: Obtusin
Bioactivity of Obtusin
Description: obtusin is from cassia seed. It is a highly selective and competitive inhibitor of human monoamine oxidase-A (hmao-a), with IC50 of 11.12 μ M. Ki is 6.15. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression.
Related Categories: signal pathway > > neural signal pathway > > monoamine oxidase
Research field > > neurological diseases
Target: IC50: 11.12 μ M (hMAO-A) Ki: 6.15 (hMAO-A)
References:  Paudel P, et al. In Vitro and in Silico Human Monoamine Oxidase Inhibitory Potential of Anthraquinones, Naphthopyrones, and Naphthalenic Lactones from Cassia obtusifolia Linn Seeds. ACS Omega. 2019 Sep 18; 4(14):16139-16152.
Physicochemical properties Of Obtusin
Density: 1.4 ± 0.1 g / cm3
Boiling Point: 614.9 ± 55.0 ° C at 760 mmHg
Molecular Formula: c18h16o7
Molecular Weight: 344.315
Flash Point: 227.0 ± 25.0 ° C
Exact Mass: 344.089600
Steam Pressure: 0.0 ± 1.8 mmHg at 25 ° C
Refractive Index: 1.634
Obtusin Safety Information
Customs Code: 2914690090
Literature: Cameron, Donald W; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 - 5002
Customs Code: 2914690090
Chinese Overview: Chinese overview
Summary:2914690090 other quinones。 Supervision conditions:None。 VAT:17.0%。 Tax rebate rate:9.0%。 MFN tariff:5.5%。 General tariff:30.0%
English Alias Of Customs
Product Quality Control
1. The company purchased nuclear magnetic resonance (Bruker 400MHz) spectrometer, liquid phase mass spectrometer (LCMS), gas phase mass spectrometer (GCMs), mass spectrometer (water SQD), multiple automatic analytical high performance liquid chromatographs, preparative liquid chromatographs, etc.
2. The company maintains close cooperation and contact with scientific research institutions such as Shanghai Institute for drug control, Nanjing biomedical public service platform and analysis and testing center of Shanghai Pharmaceutical Industry Research Institute.
3. The company is actively carrying out laboratory third-party testing certification, and is expected to obtain CNAs Laboratory Accreditation Certificate in 2021.