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Oloa

Pachymic Acid

Fa'amatalaga Puupuu:

Igoa masani: pachymic acid

Numera CAS: 29070-92-6

Molecular Weight: 528.763

Malosi: 1.1 ± 0.1 g / cm3

Fa'apuna: 612.2 ± 55.0 ° C ile 760 mmHg

Fuafuaga mole: C33H52O5

Lisi Lisi: n / A

MSDS: N / A

Fa'asao: 184.7 ± 25.0 ° C


Fa'amatalaga Oloa

Faailoga o oloa

Fa'aaogāina ole Su'a Pachymic

Pachymic acid ose triterpenoid mai P. cocos.O le pachymic acid e taofia ai le Akt ma le ERK ala fa'ailoga.

Igoa ole Pachymic Acid

Igoa Saina: Poria acid

Igilisi Igoa: pachymic acid

Fa'aSaina igoa: Poria acid Fulvic acid

Bioactivity o Pachymic Acid

Fa'amatalaga:
pachymic acid o se triterpenoid mai le P. cocos.O le pachymic acid e taofia ai le Akt ma le ERK ala fa'ailoga.

Vaega Fa'atatau:
fanua su'esu'e > > kanesa
Oloa Faanatura > > terpenoids ma glycosides

Sini:
Akt
ERK

Su'esu'ega In Vitro:
pachymic acid (PA) e mafai ona taofia le tumorigenesis o le kanesa gallbladder e aofia ai le Akt ma le ERK ala faailoilo.O le togafitiga o le pachymic acid (PA) na matua taofia ai auala Rho a, Akt ma ERK i sela o le kanesa o le gallbladder.O togafitiga o le pachymic acid (PA) e mafai ona fa'alaloina le PCNA, ICAM-1, RhoA, p-Akt ma le pa'u ile fua fa'atatau.12 itula i le maeʻa ai o togafitiga, 10 μG / ml Poria acid (PA) faʻasaina le tuputupu aʻe o sela i se faʻatonuga o le 30 μG / ml faʻaititia atili ai le tuputupu aʻe o sela.Na taofia le tuputupu aʻe o sela i se taimi - ma faʻalagolago i fua.A maeʻa le 48 itula o togafitiga, o le faʻatonuga o le 10 μg / mL, 20 μG / ml ma le 30 μ Pachymic acid (PA) i le g / ml faʻalavelaveina le tuputupu aʻe o sela e tusa ma le 25%, 40% ma le 70%.O le pachymic acid (PA) e taofia foi le tuputupu aʻe o sela o le kanesa o le gallbladder i se taimi-faʻalagolago ma faʻalagolago i fua [1].

I Vivo Suesuega:
ina ia mafai ona iloilo le gaioiga antitumor o le pachymic acid (PA) i vivo, o le kanesa mama o le tagata nci-h23 tumo xenograft faʻataʻitaʻiga na faʻaaogaina.O le pachymic acid (PA) na matua faʻalavelaveina le tuputupu aʻe o le tuma i tui o le 30 ma le 60 mg / kg mo le 21 aso pe a faʻatusatusa i le vaega o loʻo pulea [2].

Su'ega Su'e:
kit faitau sela-8 (CCK-8) na faʻaaogaina e iloilo ai le faʻalavelave faʻateleina o le pachymic acid (PA) i luga o sela GBC-SD.I se faapuupuuga, a maeʻa togafitiga faʻapitoa, faʻaopoopo le 10 i pu taʻitasi μ Lcck-8 solution, ma a maeʻa le tasi faʻamaʻi, na fuaina le absorbance i le 450 nm e faʻaaoga ai le microplate reader [1].

Fa'ata'ita'i Manu:
isumu [2] fa'aaoga isumu tama'ita'i athymic nude e 4-5 vaiaso le matutua.O sela nci-h23 ua tupu tele (i le 100 μ 5 i LPBs × 106) ua tui i lalo i le itu taumatau o isumu taʻitasi.Tumor xenografts na tupu aʻe i le averesi tele o le 100-200mm 3 ma tuʻuina faʻafuaseʻi i vaega eseese o togafitiga e fa (6 isumu i vaega taʻitasi): (a) faʻatonutonu taavale (0.1% DMSO i le saline masani);(b)Pachymic acid(PA)10 mg/kg;(c)PA 30 mg/kg;(Dd)PA 60mg/kg. Na tu'uina atu isumu ile tui ile intraperitoneal (IP) mo le 3 vaiaso (5 aso/vaiaso).O le tele o le tuma sa fuaina i luga o matau e lua ma le fesoasoani a le vernier caliper, ma sa fuafuaina le maualuga o le tuma (mm3).

Fa'asinomaga:
[1].Chen Y, et al.Pachymic acid e taofia le tumorigenesis i sela o le gallbladder carcinoma.Int J Clin Exp Med.2015 Oketopa 15;8(10):17781-8.
[2].Ma J, et al.O le pachymic acid e fa'aosofia ai le apoptosis e ala i le fa'agaoioia o ala fa'amamafa JNK ma ER fa'alagolago i le ROS i sela o le kanesa mama.Cancer Cell Int.2015 Aug 5;15:78.

Meatotino Physicochemical O Pachymic Acid

Malosi: 1.1 ± 0.1 g / cm3

Fa'apuna: 612.2 ± 55.0 ° C ile 760 mmHg

Fuafuaga mole: C33H52O5

Molecular Weight: 528.763

Fa'asao: 184.7 ± 25.0 ° C

Misasa'o: 528.381470

PSA:83.83000

Fa'amaumauga:8.59

Fa'aaliga: Pa'epa'e pa'epa'e

O'omiga ausa: 0.0 ± 4.0 mmHg ile 25°C

Fa'asinomaga fa'asaga: 1.540

Fa'aigoa Igilisi ole Pachymic Acid

pachimic acid

Lanost-8-en-21-oic acid, 3-(acetyloxy)-16-hydroxy-24-methylene-, (3β,16α)-

3-O-Acetyltumulosic acid

3-ACETYLTUMULOSIC ACID

Lanost-8-en-21-oicacid,3-(acetyloxy)-16-hydroxy-24-methylene-,(3beta,16alpha)

(3β,16α)-3-Acetoxy-16-hydroxy-24-methylenelanost-8-en-21-oic acid

Lanost-8-en-21-oic acid,3-(acetyloxy)-16-hydroxy

Lanost-8-en-21-oic acid,3-(acetyloxy)-16-hydroxy


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