Salvianolic acid C
Faamoemoega
O le Salvianolic acid C ose fa'atosina e le fa'atauva'a o le cytochrome p4502c8 (cyp2c8) ma le fa'afefiloi fa'afefiloi o le cytochrome P4502J2 (CYP2J2) fa'atasi ma le malosi.O lona Ki tau mo cyp2c8 ma CYP2J2 e 4.82 μ M ma le 5.75 μ M.
Igoa Igilisi
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)- 7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy)propanoic acid
Fa'aigoa Igilisi
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2 -enoyl}oxy)propanoic acid
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy)propanoic acid
Benzenepropanoic acid, α-[[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3, 4-dihydroxy-, (αR)-
Salvianolic acid C
Tulaga Fa'aletino ole Salvianolic Acid C
Malosi: 1.6 ± 0.1 g / cm3
Fa'apuna: 844.2 ± 65.0 ° C ile 760 mmHg
Fuafuaga mole: C26H20O10
Molecular Weight: 492.431
Tulaga emo: 464.4 ± 34.3 ° C
Misasa'o: 492.105652
PSA:177.89000
LogP: 3.12
O'omiga ausa: 0.0 ± 3.3 mmHg ile 25°C
Fa'ailoga fa'atusa: 1.752
Bioactivity ole Salvianolic Acid C
Fa'amatalaga:
O le Salvianolic acid C ose fa'atosina e le fa'atauva'a o le cytochrome p4502c8 (cyp2c8) ma le fa'afefiloi fa'afefiloi o le cytochrome P4502J2 (CYP2J2) fa'atasi ma le malosi.O lona Ki tau mo cyp2c8 ma CYP2J2 e 4.82 μM ma le 5.75 μM.
Vaega talafeagai:
Ala fa'ailoga > > metabolic enzyme / protease > > cytochrome P450
Su'esu'ega > > kanesa
Oloa Faanatura > > isi
Sini:
CYP2C8:4.82 μM (Ki)
CYP2J2:5.75 μM (Ki)
Su'esu'ega In Vitro:
Salvianolic acid C ose fa'afefiloi fefiloi fa'atauva'a ole fa'atauvaga cyp2c8 inhibitor ma CYP2J2.O le KIS o le cyp2c8 ma le CYP2J2 o le 4.82 ma le 5.75 i le faasologa μ M[1]. 1 ma le 5 μM salvianolic acid C (SALC) e mafai ona matua fa'alavelaveina le LPS fa'aosoina leai se gaosiga.O le Salvianolic acid C na matua faʻaitiitia ai le faʻaalia o le iNOS.O le Salvianolic acid C e taofia ai le fa'aosoina o le LPS o le TNF-α, IL-1 β, IL-6 ma le IL-10 ua ova le gaosiga.O le Salvianolic acid C e taofia ai le fa'agaioiina o le NF-κ B fa'aosoina o le LPS.Salvianolic acid C na faʻateleina foi le faʻamatalaga o le Nrf2 ma le HO-1 i le BV2 microglia [2].
I Vivo Studies:
O le salviolic acid C (20mg/kg) togafitiga na matua fa'aitiitia ai le fa'aletonu o le sola.E le gata i lea, o le SALC (10 ma le 20 mg / kg) togafitiga na matua faʻateleina ai le numera o faʻasalalauga faʻavae pe a faʻatusatusa i le LPS faʻataʻitaʻiga vaega.Fa'atusatusa i le fa'ata'ita'iga fa'ata'ita'iga, fa'atonuga o le salvianolic acid C lalo fa'atonutonu fai'ai TNF-α， IL-1 β Ma IL-6 maualuga.O le maualuga o le iNOS ma le COX-2 i le cerebral cortex ma le hippocampus o isumu na maualuga atu nai lo i latou o loʻo i totonu o le vaega e pulea, ae o le salvianolic acid C togafitiga na matua faʻatonutonuina le cortex ma le hippocampus.Salvianolic acid C (5, 10 ma 20 mg / kg) togafitiga faʻateleina p-ampk, Nrf2, HO-1 ma NQO1 maualuga i rat cerebral cortex ma hippocampus i se fua faʻalagolago [2].
Fa'asinomaga:
[1].Xu MJ, et al.Aafiaga faʻalavelave o vaega Danshen ile CYP2C8 ma le CYP2J2.Chem Biol Interact.2018 Iuni 1;289:15-22.
[2].Pese J, et al.O le faʻaosoina o le Nrf2 faʻailoga e le salvianolic acid C e faʻaitiitia ai le NF κ B faʻasalalau tali faʻamaʻi i vivo ma in vitro.Int Immunopharmacol.2018 Oke;63:299-310.
