Isoliquiritin Apioside
Codsiga Isoliquiritin Apioside
Isoliquiritin apioside, oo ah qayb ka go'an glycorrhizae radio rhome, ayaa si weyn hoos ugu dhigtay kororka PMA ee dhaqdhaqaaqa MMP9 waxayna joojisay PMA-ga MAPK iyo NF-κ B.Isoliquitin apioside waxay joojisaa duulaanka iyo angiogenesis ee unugyada kansarka iyo unugyada endothelial.
Magaca Isoliquiritin Apioside
Magaca Shiinaha:Isoliquiritin Apioside
Magaca Ingiriisiga:(E)-3-[4-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl] oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1- (2,4-dihydroxyphenyl) prop-2-en-1-one
Bioactivity ee Isoliquiritin Apioside
Sharaxaad:isoliquitin apioside, qayb ka go'an glycorrhizae radio rhome, ayaa si weyn hoos u dhigtay kororka PMA ee dhaqdhaqaaqa MMP9 waxayna joojisay PMA-ga MAPK iyo NF-κ B.Isoliquitin apioside waxay joojisaa duulaanka iyo angiogenesis ee unugyada kansarka iyo unugyada endothelial.
la xidhiidhaCmawduucyada:goobta cilmi-baarista > > kansarka
Jidka ishaarada>> Waddada calaamadda MAPK / ERK>> p38 MAPK
Dariiqa calaamadaynta > > dheef-shiid kiimikaadka enzyme / protease >> MMP
Bartilmaameedka:MMP9
NF-κB
p38 MAPK
Barashada vitro:isorlicin waxay si wax ku ool ah u joojin kartaa gelation MMP-9 ee PMA ay keentay unugyada HT1080.Isoglycyrrhizin apigenin waxay yaraynaysaa kororka wax soo saarka MMP-9 ee unugyada HT1080 ee ay keentay PMA, waxay leedahay awooda anti metastasis iyo anti angiogenesis ee unugyada burooyinka malignantiga ah iyo unugyada endothelial, oo aan lahayn cytotoxicity [1].
Tixraac:[1]Kim A1, iyo al.Isoliquiritin Apioside waxay xakameysaa in vitro Invasiveness iyo Angiogenesis ee Unugyada Kansarka iyo Unugyada Endothelial. Farmashiyaha hore.2018 Diseembar 10;9:1455.
Astaamaha physicochemical ee Isoliquiritin Apioside
Cufnaanta: 1.6 ± 0.1 g / cm3
Barta karkarinta: 901.0 ± 65.0 ° C at 760 mmHg
Qaaciddada molecular: c26h30o13
Miisaanka molecular: 550.509
Barta iftiimaya: 301.9 ± 27.8 ° C
Tirada saxda ah: 550.168640
PSA:215.83000
LogP:1.96
Cadaadiska uumiga: 0.0 ± 0.3 mmHg at 25 ° C
Tusmada dib-u-celinta: 1.709
Magaca Ingiriisiga ee Isoliquiritin Apioside
2-Propen-1-hal,1- (2,4-dihydroxyphenyl) -3-[4-[[2-O-[(2S,3R,4R) -tetrahydro-3,4-dihydroxy-4- (hydroxymethyl). -2-furanyl]-β-D-glucopyranosyl]oxy] phenyl] -, (2E)
3-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl] phenyl 2-O-[(2S,3R,4R)-3,4-dihydroxy-4 (hydroxymethyl) tetrahydro-2-furanyl]-β-D-glucopyranoside
Neolicuroside
