Methylophiopogonanone B
Codsiga Methylophiopogonanone B
Methylophiopogonone B, isodihydroflavone sare, oo laga soo saaro xididka Ophiopogon japonicus, ayaa leh awood sare oo antioxidant ah.Methylophiopogonone B waxay kordhisaa GTP Rho waxayna ku dhaqantaa jidka calaamadaynta Rho.Methylophiopogonone B waxay keentaa isbeddellada qaabdhismeedka unugyada, oo ay ku jiraan foosha dendritic iyo samaynta fiber-ka walbahaarka, iyada oo loo marayo dib-u-habaynta cytoskeleton actin.
Magaca Methylophiopogonanone B
Magaca Ingiriisiga:
(3R) -5,7-Dihydroxy-3- (4-methoxybenzyl) -6,8-dimethyl-2,3-dihydro-4 H-chromen-4-hal
Dhaqdhaqaaqa noole ee Methylophiopogonanone B
Sharaxaada: methylophiopogonone B, isodihydroflavone sare, oo laga soo saaray xididka Ophiopogon japonicus, ayaa leh awood sare oo antioxidant.Methylophiopogonone B waxay kordhisaa GTP Rho waxayna ku dhaqantaa jidka calaamadaynta Rho.Methylophiopogonone B waxay keentaa isbeddellada qaabdhismeedka unugyada, oo ay ku jiraan foosha dendritic iyo samaynta fiber-ka walbahaarka, iyada oo loo marayo dib-u-habaynta cytoskeleton actin.
Qaybaha la xidhiidha: goobta cilmi-baarista > > kale
dariiqa calaamadaynta >> G borotiinka isku-xidhka soo-dhoweeyaha /
G borotiinka >> RAS
Tixraacyada: [1] Wang Y, iyo al.Homoisoflavonoids iyo Antioxidant
Dhaqdhaqaaqa Ophiopogon japonicus Root.
Ito Y, iyo al.Wakiilka cusub, methylophiopogonanone B,
Waxay kor u qaadaa kicinta Rho iyo depolymerization tubulin.Mol Cell Biochem.2007 Mar;297 (1-2): 121-9.Epub 2006 Oct 7.
Sifooyinka kiimikaad ee Methylophiopogonanone B
Cufnaanta: 1.285
Barta karkarinta: 554.5 ± 49.0 ° C at 760 mmHg
Qaacidada molecular: C19H20O5
Miisaanka molecular: 328.359
Barta iftiimaya: 201.5 ± 23.3 ° C
Tirada saxda ah: 328.131073
PSA: 75.99000
LogP: 5.22
Cadaadiska uumiga: 0.0 ± 1.6 mmHg at 25 ° C
Tusmada dib-u-celinta: 1.617
Adeegga Yongjian
Adeegga Habboon ee Qalabka Tixraaca Kiimikada ee Daawada Dhaqanka ee Shiinaha
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd. ayaa inta badan ku hawlan cilmi-baarista aasaasiga ah ee walxaha firfircoon ee daawada dhaqameed ee Shiinaha in ka badan toban sano.Ilaa hadda, shirkaddu waxay cilmi-baadhis qoto-dheer ku samaysay in ka badan 100 nooc oo ah dawo-dhaqameedka Shiinaha ee inta badan la isticmaalo, waxaanay soo saartay kumannaan qaybood oo kiimiko ah.
Shirkaddu waxay leedahay shaqaale sare oo R & D ah iyo qalab tijaabo iyo falanqayn sax ah oo ku jira warshadaha, waxayna u adeegtay boqolaal machadyo cilmi baaris cilmiyeed.Waxay si dhakhso ah oo hufan u dabooli kartaa baahida macaamiisha
Kala-saar Xumo-xumo Daroogada, Diyaarinta iyo Adeegga Xaqiijinta Qaab-dhismeedka
Wasakhda daroogooyinka waxay si dhow ula xiriiraan tayada, badbaadada iyo xasiloonida daroogada.Xaqiijinta diyaarinta iyo qaab dhismeedka wasakhda daroogooyinka waxay naga caawin kartaa inaan fahamno hababka wasakhda iyo bixinta aasaaska hagaajinta habka wax soo saarka.Sidaa darteed, diyaarinta iyo kala-soocidda wasakhdu waxay muhiimad weyn u leedahay cilmi-baarista iyo horumarinta daroogada.
Si kastaba ha ahaatee, waxa ku jira wasakhda daawadu way yar tahay, isha waa ballaadhan tahay, qaab-dhismeedkuna inta badan wuxuu la mid yahay qaybta ugu muhiimsan.Tignoolajiyada noocee ah ayaa loo isticmaali karaa in lagu kala saaro oo lagu nadiifiyo dhammaan wasakhda daawada mid mid iyo si degdeg ah?Waa maxay farsamooyinka iyo hababka loo isticmaalo si loo xaqiijiyo dhismaha wasakhdaas?Tani waa dhibka iyo caqabada ay la kulmaan qaybo badan oo dawooyin ah, gaar ahaan shirkadaha dawooyinka ee dawooyinka dhirta iyo daawaynta patent-ka Shiinaha.
Iyada oo ku saleysan baahiyaha noocaas ah, shirkaddu waxay bilawday adeegyada kala soocida wasakhda iyo nadiifinta daroogada.Ku tiirsanaanta nukliyeerka magnetic nukliyeerka, spectrometry mass iyo qalabka kale iyo teknoolajiyada, shirkaddu waxay si dhakhso ah u aqoonsan kartaa qaab-dhismeedka xeryahooda kala go'ay, si loo daboolo baahiyaha macaamiisha.
Tijaabada Xayawaanka ee SPF
Bedka dhismaha ee goobta tijaabada xayawaanku waa 1500 mitir oo laba jibbaaran, oo ay ku jiraan 400 mitir oo laba jibbaaran oo aag tijaabo ah oo heerka SPF ah iyo 100 mitir oo laba jibbaaran oo ah shaybaadhka unugyada heerka P2.Oo ay hogaaminayaan saynisyahano ka tirsan Jaamacadda Pharmaceutical ee Shiinaha, waxay samaysaa koox farsamo oo xudun u ah tiro dad ah oo soo noqday.Bixi noocyo xayawaan oo tayo sare leh, naqshadeynta tijaabada, mashaariicda guud iyo adeegyada kale ee cilmi-baarista cilmiga noolaha, barida iyo horumarinta warshadaha.
Baaxadda Ganacsiga
1. quudinta xoolaha yar
2. Qaabaynta cudurada xoolaha
3. Dib-u-soo-saarka mashruuca kulliyadda
4. Qiimaynta Pharmacodynamic in vivo
5. Qiimaynta farmashiyaha
6. Adeegga tijaabada unugyada burada
Awoodeena
1. Diirada saar tijaabooyinka dhabta ah
2. Si adag u habeeyaan habka
3. Si adag u saxiix heshiiska sirta
4. Shaybaadh u gaar ah oo aan lahayn xiriiriye dhexdhexaad ah
5. Kooxda farsamada ee xirfadlayaasha ah ayaa dammaanad qaadaya tayada tijaabada ah
Deegaanka tijaabada SPF, quudinta qofka si gaar ah loo xilsaaray, la socodka wakhtiga dhabta ah ee horumarka tijaabada ah
