Isoliquiritin Apioside
Tšebeliso ea Isoliquiritin Apioside
Isoliquiritin apioside, e leng karolo e arohaneng le glycorrhizae radio rhome, e fokolitse haholo keketseho e bakiloeng ke PMA mosebetsing oa MMP9 le ho thibela PMA e entseng MAPK le NF- κ B activation.Isoliquitin apioside e thibela tlhaselo le angiogenesis ea lisele tsa mofetše le lisele tsa endothelial.
Lebitso la Isoliquiritin Apioside
Lebitso la Sechaena:Isoliquiritin Apioside
Lebitso la Senyesemane:(E) -3- [4- [(2S,3R,4S,5S,6R)-3- [(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl] oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
Bioactivity ea Isoliquiritin Apioside
Tlhaloso:isoliquitin apioside, e leng karolo e arohaneng le glycorrhizae radio rhome, e fokolitse haholo keketseho e bakiloeng ke PMA mosebetsing oa MMP9 le ho thibela PMA e kentse MAPK le NF- κ B activation.Isoliquitin apioside e thibela tlhaselo le angiogenesis ea lisele tsa mofetše le lisele tsa endothelial.
Tse amanangClihlopha:lefapha la lipatlisiso > > kankere
Tsela ea lipontšo>> MAPK / ERK tsela ea lets'oao>> p38 MAPK
Tsela ea lipontšo>> enzyme ea metabolism / protease>> MMP
Sepheo:MMP9
NF-κB
p38 MAPK
Thuto ea in vitro:Isorlicin e ka thibela ka nepo ts'ebetso ea gelation MMP-9 ea PMA e hlahisitsoeng ke lisele tsa HT1080.Isoglycyrrhizin apigenin e fokotsa keketseho ea tlhahiso ea MMP-9 liseleng tsa HT1080 tse susumetsoang ke PMA, e na le bokhoni ba anti metastasis le anti angiogenesis liseleng tse kotsi tsa hlahala le lisele tsa endothelial, 'me ha e na cytotoxicity [1].
Referense:[1].Kim A1, le ba bang.Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells.Front Pharmacol.2018 Dec 10;9:1455.
Lintho tsa physicochemical tsa Isoliquiritin Apioside
Boima: 1.6 ± 0.1 g / cm3
Sebaka se belang: 901.0 ± 65.0 ° C ho 760 mmHg
Foromo ea molek'hule: c26h30o13
Boima ba molek'hule: 550.509
Sebaka se benyang: 301.9 ± 27.8 ° C
Boima bo nepahetseng: 550.168640
PSA:215.83000
Lethathamo: 1.96
Khatello ea mouoane: 0.0 ± 0.3 mmHg ho 25 ° C
Lenane la refractive: 1.709
Lebitso la Senyesemane la Isoliquiritin Apioside
2-Propen-1-one,1-(2,4-dihydroxyphenyl) -3-[4-[[2-O-[(2S,3R,4R))-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl )-2-furanyl]-β-D-glucopyranosyl]oxy]phenyl]-, (2E)-
3-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl]phenyl 2-O-[(2S,3R,4R) -3,4-dihydroxy-4 -(hydroxymethyl)tetrahydro-2-furanyl]-β-D-glucopyranoside
Neolicuroside
