Obtusin
Tšebeliso ea Obtusin
Obtusin, ho tloha peo ea cassia, ke inhibitor e khethollang haholo le e nang le tlhōlisano ea motho monoamine oxidase-A (hmao-a), e nang le IC50 ea 11.12 μ M. Ki ke 6.15.Obtusin e bapala karolo ea thibelo ho mafu a neurodegenerative, haholo-holo matšoenyeho le khatello ea maikutlo.
Lebitso la Obtusin
Lebitso la Senyesemane: Obtusin
Bioactivity ea Obtusin
Tlhaloso: obtusin e tsoa ho peo ea cassia.Ke inhibitor e khethollang haholo le e nang le tlhōlisano ea motho monoamine oxidase-A (hmao-a), e nang le IC50 ea 11.12 μ M. Ki ke 6.15.Obtusin e bapala karolo ea thibelo ho mafu a neurodegenerative, haholo-holo matšoenyeho le khatello ea maikutlo.
Mafapha a Amanang: tsela ya matshwao > > tsela ya letshwao la methapo > > monoamine oxidase
Sebaka sa lipatlisiso > > mafu a methapo ea kutlo
Sepheo: IC50: 11.12 μ M (hMAO-A)[1] Ki: 6.15 (hMAO-A)[1]
Litšupiso: [1] Paudel P, et al.In Vitro and in Silico Human Monoamine Oxidase Inhibitory Potential of Anthraquinones, Naphthopyrones, and Naphthalenic Lactones from Cassia obtusifolia Linn Seeds.ACS Omega.2019 Sep 18;4(14):16139-16152.
Lintho tsa Physicochemical Of Obtusin
Boima: 1.4 ± 0.1 g / cm3
Ntho e Belang: 614.9 ± 55.0 ° C ho 760 mmHg
Foromo ea molek'hule: c18h16o7
Boima ba 'mele: 344.315
Flash Point: 227.0 ± 25.0 ° C
'Misa Hantle: 344.089600
PSA:102.29000
LogP:4.10
Khatello ea Mouoane: 0.0 ± 1.8 mmHg ho 25 ° C
Index ea Refractive: 1.634
Lintlha tsa Ts'ireletso ea Obtusin
Melao ea Litloaelo: 2914690090
Lingoliloeng: Cameron, Donald W;Feutrill, Geoffrey I.;Gamble, Glenn B.;Stavrakis, John Tetrahedron Letters, 1986, vol.27, # 41 leq.4999 - 5002
Mekhoa ea Obtusin
Melao ea Litloaelo: 2914690090
Kakaretso ea Sechaena: Kakaretso ea Sechaena
Kakaretso:2914690090 li-quinone tse ling。 Maemo a tlhokomelo:Ha ho letho. VAT:17.0%.
Senyesemane Alias Of Customs
9,10-Anthracenedione, 1,7-dihydroxy-2,3,8-trimethoxy-6-methyl-
1,7-dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione
1,7-Dihydroxy-2,3,8-trimethoxy-6-methyl-9,10-anthraquinone
Taolo ea Boleng ba Sehlahisoa
1. Khamphani e rekile nuclear magnetic resonance (Bruker 400MHz) spectrometer, liquid phase mass spectrometer (LCMS), gas phase mass spectrometer (GCMs), mass spectrometer (water SQD), multiple analytical high performance liquid chromatographs, preparative liquid chromatographs, joalo-joalo. .
2. Khampani e boloka tšebelisano-'moho e haufi le ho kopana le mekhatlo ea lipatlisiso tsa saense e kang Shanghai Institute for control drug, Nanjing biomedical service public service and analysis and test center of Shanghai Pharmaceutical Industry Research Institute.
3. Khampani e ntse e tsoela pele ho etsa liteko tsa laboratori tsa mokha oa boraro, 'me e lebelletsoe ho fumana Setifikeiti sa Kamohelo sa CNAs Laboratory ka 2021.
