Salvianolic acid C
Morero
Salvianolic acid C ke inhibitor e seng tlhōlisano ea cytochrome p4502c8 (cyp2c8) le inhibitor e tsoakiloeng ea cytochrome P4502J2 (CYP2J2) e nang le matla a mahareng.Maemo a eona a Ki bakeng sa cyp2c8 le CYP2J2 ke 4.82 ka ho latellana μ M le 5.75 μ M
Lebitso la Senyesemane
(2R) -3-(3,4-Dihydroxyphenyl) -2-({(2E)-3-[2-(3,4-dihydroxyphenyl)- 7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy) propanoic acid
Senyesemane Alias
(2R) -3-(3,4-Dihydroxyphenyl) -2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2 -enoyl}oxy) propanoic acid
(2R) -3-(3,4-Dihydroxyphenyl) -2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy) propanoic acid
Benzenepropanoic acid, α--[[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3, 4-dihydroxy-, (αR)-
Salvianolic acid C
Lintho tsa Physicochemical tsa Salvianolic Acid C
Boima: 1.6 ± 0.1 g / cm3
Ntho e Belang: 844.2 ± 65.0 ° C ho 760 mmHg
Foromo ea molek'hule: C26H20O10
Boima ba 'mele: 492.431
Sebaka se phatsimang: 464.4 ± 34.3 ° C
'Misa Hantle: 492.105652
PSA: 177.89000
Tlhaloso: 3.12
Khatello ea Mouoane: 0.0 ± 3.3 mmHg ho 25 ° C
Lenane la refractive: 1.752
Bioactivity ea Salvianolic Acid C
Tlhaloso:
Salvianolic acid C ke inhibitor e seng tlhōlisano ea cytochrome p4502c8 (cyp2c8) le inhibitor e tsoakiloeng ea cytochrome P4502J2 (CYP2J2) e nang le matla a mahareng.Lipalo tsa eona tsa Ki bakeng sa cyp2c8 le CYP2J2 ke 4.82 ka ho latellana μ M le 5.75 μ M.
Lihlopha tse amehang:
Tsela ea lipontšo>> enzyme ea metabolic / protease>> cytochrome P450
Sebaka sa lipatlisiso> > kankere
Lihlahisoa tsa Tlhaho > > tse ling
Sepheo:
CYP2C8:4.82 μM (Ki)
CYP2J2:5.75 μM (Ki)
Thuto ea In Vitro:
Salvianolic acid C ke inhibitor e leka-lekaneng e tsoakiloeng ea cyp2c8 inhibitor e se nang tlhōlisano le CYP2J2.The KIS ea cyp2c8 le CYP2J2 ke 4.82 le 5.75 ka ho latellana μ M[1]。 1 le 5 μ M salvianolic acid C (SALC) e ka thibela haholo LPS e entseng hore ho se be le tlhahiso.Salvianolic acid C e fokolitse haholo polelo ea iNOS.Salvianolic acid C e thibela LPS e entsoeng TNF- α, IL-1 β, IL-6 le IL-10 e ne e hlahisoa ka bongata.Salvianolic acid C e thibela LPS e susumelitsoeng ke NF- κ B ts'ebetsong.Salvianolic acid C e boetse e ekelitse polelo ea Nrf2 le HO-1 ho BV2 microglia [2].
Lithutong tsa Vivo:
Kalafo ea Salvianolic acid C (20mg / kg) e fokolitse haholo nako ea ho baleha.Ntle le moo, kalafo ea SALC (10 le 20 mg / kg) e ekelitse palo ea lipallo tsa sethala ha e bapisoa le sehlopha sa mohlala oa LPS.Ha ho bapisoa le sehlopha sa mohlala, tsamaiso ea tsamaiso ea salvianolic acid C e theohile boko bo laoloang TNF- α, IL-1 β Le maemo a IL-6.Maemo a iNOS le COX-2 ka har'a cerebral cortex le hippocampus ea likhoto a ne a le holimo ho feta a sehlopha sa taolo, athe phekolo ea salvianolic acid C e ne e laola cortex le hippocampus haholo.Salvianolic acid C (5, 10 le 20 mg / kg) phekolo e eketsehile p-ampk, Nrf2, HO-1 le NQO1 maemong a rat cerebral cortex le hippocampus ka mokhoa o itšetlehileng ka lethal dose [2].
Referense:
[1].Xu MJ, le ba bang.Liphello tse thibelang tsa likarolo tsa Danshen ho CYP2C8 le CYP2J2.Tšebelisano ea Chem Biol.2018 Jun 1;289:15-22 .
[2].Sefela J, le ba bang.Ts'ebetso ea pontšo ea Nrf2 ka salvianolic acid C e thibela NF κ B karabelo ea ho ruruha lipakeng tsa vivo le in vitro.Ho ea ka Immunopharmacol.2018 Oct;63:299-310.
