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Lihlahisoa

Tanshinone IIA

Tlhaloso e Khutšoanyane:

Lebitso le Tloaelehileng: tanshinone IIA

Lebitso la Senyesemane: tanshinone IIA

Nomoro ea CAS: 568-72-9

Boima ba 'mele: 294.344

Boima: 1.2 ± 0.1 g / cm3

Ntho e Belang: 480.7 ± 44.0 ° C ho 760 mmHg

Foromo ea molek'hule: c19h18o3

Sebaka se qhibilihang: 205-207 ºC

Sebaka se benyang: 236.4 ± 21.1 ° C


Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Mokhoa oa ho boloka

Tanshinone IIA (Tan IIA) ke e 'ngoe ea metsoako ea mantlha e qhibilihang ka mafura metsong ea motso o mofubelu Salvia miltiorrhiza.Tanshinone IIA e ka thibela angiogenesis ka ho lebisa protheine kinase domain ea VEGF / VEGFR2.

Lebitso la Tanshinone IIA

Lebitso la Senyesemane:tanshinone IIA
Lebitso la Sechaena:tanshinone |tanshinone IIA |tanshinone 2A |tanshinone IIA |tanshinone IIA ts'ebetso ea likokoana-hloko

Tlhaloso:
Tanshinone IIA (Tan IIA) ke e 'ngoe ea metsoako ea mantlha e qhibilihang ka mafura metsong ea motso o mofubelu Salvia miltiorrhiza.Tanshinone IIA e ka thibela angiogenesis ka ho lebisa protheine kinase domain ea VEGF / VEGFR2.

Lihlopha tse amehang:
Sebaka sa lipatlisiso > > lefu la pelo
Lihlahisoa tsa Tlhaho > > Quinones

Sepheo:
VEGF/VEGFR2[1]

Thuto ea In Vitro:Litlamorao tsa antitumor tsa tanshinone IIA li kenyelletsa ho thibela ho ata ha lisele tsa tumor, ho sitisa potoloho ea lisele tsa tumor, ho khothaletsa tumor cell apoptosis le ho thibela tlhaselo ea lisele tsa tumor le metastasis.Tanshinone IIA e ne e e-na le phello e khahlanong le ho ata ha lisele tsa A549: IC50 ea tanshinone IIA ka mor'a lihora tse 24, 48 le 72 e ne e le 145.3, 30.95 le 11.49, ka ho latellana μ M. CCK-8 assay e ne e sebelisetsoa ho hlahloba tanshinone IIA μ-80 μ-25 (25). Ts'ebetso e ntseng e eketseha ea lisele tsa A549 tse tšoaroang lihora tse 24, 48 le 72, ka ho latellana.Liphetho tsa CCK-8 li bontšitse hore tanshinone IIA e ka thibela haholo ho ata ha lisele tsa A549 ka mokhoa o itšetlehileng ka tekanyo le nako e itšetlehileng ka eona.Apoptosis ea bohlokoa le thibelo ea kholo ea lisele tsa lisele tsa A549 li ile tsa hlokomeloa lihora tse 48 ka mor'a phekolo ea lithethefatsi (mahloriso a sebelisitsoeng e ne e le ka boleng ba IC50: tanshinone iia31 ho A549) μ M) . μ M), ho theosa ho laola polelo ea protheine ea VEGF le VEGFR2 sehlopheng sa kalafo ea lithethefatsi le vector [1].Tanshinone IIA ke e 'ngoe ea likarolo tse ngata haholo tsa motso oa Salvia miltiorrhiza, o ka sireletsang lisele tsa H9c2 ho tloha ho apoptosis.Lisele tsa H9c2 tse tšoaroang ka tanshinone IIA li thibetse angiotensin II li kentse apoptosis ka ho laola polelo ea PTEN (phosphatase le tensin homologue).PTEN ke sehatelli sa tumor se bapalang karolo ea bohlokoa ho apoptosis.Tanshinone IIA e thibela angiotensin II (AngII) - e susumelitseng apoptosis ka ho theola ho laola polelo ea phosphatase le tensin homologue (PTEN) [2].Tanshinone IIA e fokotsa polelo ea protheine ea EGFR, 'me IGFR e thibela tsela ea PI3K / Akt / mTOR ho lisele tsa AGS tsa mofetše oa gastric [3].

Teko ea Cell:Lisele tsa A549 li ne li baloa karolong ea logarithmic le lisele tse 6000 (bolumo ea 90 μ L) ka poleiti ea seliba ea 96.Tla 10 μ L fapaneng concentrations tsa tanshinone IIA (concents ho qetela 80,60,40,30,20,15,10,5 le 2.5 μ M) Le ADM (concents ea ho qetela 8,4,2,1,0.5 le 0.25 μ M ) E ile ea eketsoa sehlopheng sa lithethefatsi, ha sehlopha sa taolo e mpe (sehlopha sa bajari) se ekelitsoe feela 10 μ Ldmso kapa saline e tloaelehileng ntle le tanshinone IIA kapa Adm Kopanya lisele le CCK-8 reagent (100 μ L / ml medium) bakeng sa lihora tse ling tsa 2, 'me ho monya ho ne ho baloa ho 450 nm ho sebelisa sebali sa microplate.Sekhahla sa thibelo ea ho ata ha lisele se baloa ho latela mokhoa o latelang: sekhahla sa thibelo ea ho ata (%) = 1 - [(A1-A4) / (A2-A3)] × 100, moo A1 e leng boleng ba OD ba sehlopha sa liteko tsa lithethefatsi, A2 ke boleng ba OD ba sehlopha sa taolo e se nang letho, A3 ke boleng ba OD ba RPMI1640 medium ntle le lisele, 'me A4 ke boleng ba OD ba lithethefatsi tse nang le mahloriso a tšoanang le A1 empa ntle le lisele.Boleng ba IC50 bo ne bo baloa ka tlhahlobo e sa tloaelehang ea ho fokotseha ho sebelisoa software ea graphpad prism [1], e emelang khatello ea lithethefatsi e bontšang 50% thibelo ea kholo ea lisele.

Referense:[1].Xie J, le ba bang.Phello ea antitumor ea tanshinone IIA ho anti-proliferation le ho fokotseha ha VEGF/VEGFR2 polelong ea mofets'e o seng o monyane oa mofetše oa matšoafo oa sele ea A549.Acta Pharm Sin B. 2015 Nov;5(6):554-63.
[2].Zhang Z, le ba bang.Tanshinone IIA e thibela apoptosis ka har'a myocardium ka ho susumetsa polelo ea microRNA-152-3p mme ka hona e theola PTEN.Ke J Transl Res.2016 Jul 15;8(7):3124-32.
[3].Su CC, le ba bang.Tanshinone IIA e fokotsa ponahatso ea protheine ea EGFR, le IGFR e thibelang tsela ea PI3K/Akt/mTOR ka har'a gastric carcinoma AGS cell in vitro and in vivo.Oncol Rep. 2016 Aug;36(2):1173-9.

Lintho tsa physicochemical tsa tanshinone IIA

Boima: 1.2 ± 0.1 g / cm3

Ntho e Belang: 480.7 ± 44.0 ° C ho 760 mmHg

Sebaka se qhibilihang: 205-207 ºC

Foromo ea molek'hule: c19h18o3

Boima ba 'mele: 294.344

Flash Point: 236.4 ± 21.1 ° C

'Misa Hantle: 294.125580

PSA: 47.28000

Lethathamo: 5.47

Ponahalo: Crystal

Khatello ea Mouoane: 0.0 ± 1.2 mmHg ho 25 ° C

Index ea Refractive: 1.588

Maemo a polokelo: 2-8 ° C

Tanshinone IIA Information Information Safety

Thepa ea Tšireletso ea Botho: litšiea tsa mahlo;Liatlana;mofuta oa N95 (US);mofuta oa P1 (EN143) filthara ea ho phefumoloha

Khoutu ea Lipalangoang ea Thepa e Kotsi: nonh bakeng sa mefuta eohle ea lipalangoang

Lingoliloeng tsa Tanshinone IIA

Meetlo Code: 2942000000

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Tanshinone IIA English Alias

Phenanthrop[1,2-b]furan-10,11-dione, 6,7,8,9-tetrahydro-1,6,6-trimethyl-

Tanshinone IIA

tanshinone II-A

Dan Shen Ketone

Tanshionesiia

Tanshine II

TANYA PE

1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione

MonateOrange

MFCD00238692

QS-D-77-4-2

TANSHINONE A

Tanshiones

Tanshinone II


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