Iimveliso

I-Chlorogenic acid inoluhlu olubanzi lwezinto eziphilayo.Uphando malunga nemisebenzi yebhayoloji ye-chlorogenic acid kwisayensi yanamhlanje iye yangena nzulu kwiinkalo ezininzi, njengokutya, ukhathalelo lwempilo, amayeza, ishishini lemichiza yemihla ngemihla njalo njalo.I-Chlorogenic acid yinto ebalulekileyo ye-bioactive, enemisebenzi ye-antibacterial, i-antiviral, inyusa i-leukocyte, ikhusela isibindi kunye ne-gallbladder, i-anti-tumor, ihlisa uxinzelelo lwegazi, ihlisa i-lipid yegazi, ikhupha i-radicals yamahhala kunye neyona nto inomdla kwinkqubo ye-nervous central.

I-antibacterial kunye ne-antiviral
I-Eucommia ulmoides i-chlorogenic acid ineempembelelo ezinamandla zokulwa ne-antibacterial kunye ne-anti-inflammatory, i-aucubin kunye neepolymers zayo zineempembelelo ezicacileyo zokulwa ne-antibacterial, kwaye i-aucubin ineempembelelo ezithintelayo kwi-Gram-negative kunye neebhaktheriya ezilungileyo.I-Aucubin ineempembelelo ze-bacteriostatic kunye ne-diuretic, kwaye inokukhuthaza ukuphulukiswa kwesilonda;I-Aucubin kunye ne-glucoside inokuvelisa i-antiviral effect ecacileyo emva kwenkcubeko yangaphambili, kodwa ayinayo umsebenzi we-antiviral.I-Institute of aging Medical Sciences, i-Aichi Medical University, iqinisekisile ukuba i-alkaline substance ekhutshwe kwi-Eucommia ulmoides Oliv.Unamandla okutshabalalisa intsholongwane ye-immune system.Le nkunkuma ingasetyenziselwa ukuthintela kunye nokunyanga i-AIDS.

I-Antioxidation
I-Chlorogenic acid yi-phenolic antioxidant esebenzayo.Umthamo wayo we-antioxidant unamandla kune-caffeic acid, i-p-hydroxybenzoic acid, i-ferulic acid, i-syringic acid, i-butyl hydroxyanisole (BHA) kunye ne-tocopherol.I-Chlorogenic acid ine-antioxidant effect kuba iqulethe umlinganiselo othile we-R-OH radical, enokwenza i-hydrogen radical ene-antioxidant effect, ukuze kupheliswe umsebenzi we-hydroxyl radical, i-anion ye-superoxide kunye nezinye ii-radicals zamahhala, ukwenzela ukukhusela izicubu kwi-oxidative. umonakalo.

Ukugxothwa kwasimahla, ukuchasa ukuguga, ukuguga kwe-musculoskeletal
I-Chlorogenic acid kunye nezinto eziphuma kuyo zinempembelelo eyomeleleyo yokutshabalalisa i-radical yasimahla kune-ascorbic acid, i-caffeic acid kunye ne-tocopherol (ivithamin E), inokutshabalalisa ngokufanelekileyo i-DPPH yasimahla yeradical, i-hydroxyl yasimahla yeradical kunye ne-superoxide anion yasimahla, kwaye inokuthintela i-oxidation yoxinaniso oluphantsi. lipoprotein.I-Chlorogenic acid idlala indima ebalulekileyo ekukhupheni ngokufanelekileyo i-radicals yamahhala, ukugcina isakhiwo esiqhelekileyo kunye nomsebenzi weeseli zomzimba, ukuthintela kunye nokulibazisa ukwenzeka kwe-tumor mutation kunye nokuguga.I-Eucommia chlorogenic acid iqulethe icandelo elikhethekileyo elinokukhuthaza ukuhlanganiswa kunye nokubola kwe-collagen kwisikhumba somntu, ithambo kunye nemisipha.Inomsebenzi wokukhuthaza imetabolism kunye nokuthintela ukuhla.Ingasetyenziselwa ukuthintela ukuhla kwethambo kunye nezihlunu okubangelwa bubunzima besithuba.Kwangaxeshanye, kufunyaniswe ukuba i-Eucommia chlorogenic acid ineempembelelo ezicacileyo ezichasene ne-radical yasimahla zombini kwi-vivo nakwi-vitro.

Ukuthintela utshintsho kunye ne-antitumor
Imifuniselo yanamhlanje ye-pharmacological ibonise ukuba i-Eucommia ulmoides i-chlorogenic acid ineempembelelo zokuchasana nomhlaza kunye nokuchasana nomhlaza.Abaphengululi Japanese baye bafunda antimutagenicity of Eucommia ulmoides chlorogenic acid waza wafumanisa ukuba esi siphumo inxulumene amacandelo anti mutagenic ezifana chlorogenic acid, eveza ukubaluleka okubalulekileyo chlorogenic acid kuthintelo ithumba.
Iipolyphenols kwimifuno kunye neziqhamo, ezifana ne-chlorogenic acid kunye ne-caffeic acid, inokuthintela i-mutagenicity ye-carcinogens i-aflatoxin B1 kunye ne-benzo [a] - i-pyrene ngokuvimbela i-enzymes esebenzayo;I-Chlorogenic acid inokuphinda ifikelele kwi-anti-cancer kunye ne-anti-cancer imiphumo ngokunciphisa ukusetyenziswa kwe-carcinogens kunye nokuthutha kwabo esibindi.I-Chlorogenic acid ineempembelelo ezibalulekileyo zokuthintela umhlaza we-colorectal, umhlaza wesibindi kunye nomhlaza we-laryngeal.Kuthathwa njengento esebenzayo yokukhusela ikhemikhali kumhlaza.

Impembelelo yokukhusela kwi-cardiovascular system
Njenge-scavenger ye-radical yasimahla kunye ne-antioxidant, i-chlorogenic acid ibonakaliswe linani elikhulu leemvavanyo.Lo msebenzi webhayoloji we-chlorogenic acid unokukhusela inkqubo ye-cardiovascular system.I-Isochlorogenic acid B inefuthe elinamandla ekukhuthazeni ukukhululwa kwe-prostacyclin (PGI2) kunye ne-anti platelet aggregation kumagundane;Izinga lothintelo lokukhutshwa kwe-SRS-A olubangelwa li-antibody kwi-guinea pig lung debris kwimiphunga yayingama-62.3%.I-Isochlorogenic acid C nayo yakhuthaza ukukhululwa kwePGI2.Ukongezelela, i-isochlorogenic acid B inempembelelo enamandla yokuthintela kwiplatelet thromboxane biosynthesis kunye nokulimala kwe-endothelin okubangelwa yi-hydrogen peroxide.

Isiphumo se-Hypotensive
Kungqinwe iminyaka emininzi yolingo lwezonyango ukuba i-Eucommia chlorogenic acid inesiphumo esicacileyo se-antihypertensive, isiphumo esizinzileyo sokunyanga, esingenabungozi kwaye akukho ziphumo bezingalindelekanga.IYunivesithi yaseWisconsin yafumanisa ukuba amacandelo asebenzayo Eucommia ulmoides eluhlaza ukunciphisa uxinzelelo lwegazi terpineol diglucoside, aucubin, chlorogenic acid, kunye Eucommia ulmoides chlorogenic acid polysaccharides.[5]

Eminye imisebenzi yebhayoloji
Ngenxa yokuba i-chlorogenic acid inempembelelo ekhethekileyo yokuthintela kwi-hyaluronic acid (HAase) kunye ne-glucose-6-phosphatase (gl-6-pase), i-chlorogenic acid inefuthe elithile ekuphulukiseni amanxeba, impilo yesikhumba kunye nokumanzisa, ukuthambisa amalungu, ukuthintela ukudumba kunye nokuvuvukala. ibhalansi yokulawula iswekile yegazi emzimbeni.I-Chlorogenic acid ine-inhibitory enamandla kunye nemiphumo yokubulala kwiintlobo zezifo kunye neentsholongwane.I-Chlorogenic acid ineempembelelo ze-pharmacological zokunciphisa uxinzelelo lwegazi, i-antibacterial, i-antiviral, i-anti-inflammatory, ukwandisa iiseli zegazi ezimhlophe, ukuthintela isifo seswekile, ukwandisa ukuhamba kwesisu kunye nokukhuthaza ukukhutshwa kwesisu.Uphononongo lubonise ukuba i-chlorogenic acid yomlomo inokuvuselela kakhulu ukukhutshwa kwe-bile kwaye inefuthe lokuzuza i-gallbladder kunye nokukhusela isibindi;Kwakhona kunokuthintela ngokufanelekileyo i-hemolysis ye-rat erythrocytes ebangelwa yi-H2O2.