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Iimveliso

Isoliquiritin Apioside

Inkcazelo emfutshane:

Igama eliqhelekileyo: apigenin isoglycyrrhizin

Igama lesiNgesi: i-isoliquitin apioside

Inombolo yeCAS: 120926-46-7

Ubunzima beMolekyuli: 550.509

Ubuninzi: 1.6 ± 0.1 g / cm3

Indawo yokuBilisa: 901.0 ± 65.0 ° C kwi-760 mmHg

Ifomula yemolekyuli: C26H30O13

Indawo ekunyibilika kuyo: N/ A

I-MSDS: N/A

Indawo edanyazayo: 301.9 ± 27.8 ° C


Iinkcukacha zeMveliso

Iithegi zeMveliso

Ukusetyenziswa kwe-Isoliquiritin Apioside

I-Isoliquiritin apioside, icandelo elihlukanisiweyo kwi-glycorrhizae radio rhome, yanciphisa kakhulu i-PMA eyenza ukunyuka komsebenzi we-MMP9 kwaye ivimbele i-PMA eyenza i-MAPK kunye ne-NF- κ B isebenze.I-Isoliquitin apioside inqanda ukuhlasela kunye ne-angiogenesis yeeseli zomhlaza kunye neeseli ze-endothelial.

Igama le-Isoliquiritin Apioside

Igama lesiTshayina:Isoliquiritin Apioside

Igama lesiNgesi:(E) -3- [4- [(2S,3R,4S,5S,6R)-3- [(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl] oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one

I-Bioactivity ye-Isoliquiritin Apioside

Inkcazo:i-isoliquitin apioside, inxalenye eyodwa kwi-glycorrhizae radio rhome, yanciphisa kakhulu ukunyuka kwe-PMA eyenziwa ngumsebenzi we-MMP9 kwaye ivimbele i-PMA eyenza i-MAPK kunye ne-NF- κ B isebenze.I-Isoliquitin apioside inqanda ukuhlasela kunye ne-angiogenesis yeeseli zomhlaza kunye neeseli ze-endothelial.

EzinxulumeneyoCiindidi:icandelo lophando > > umhlaza
Indlela yomqondiso > > I-MAPK / indlela yesignali ye-ERK > > p38 MAPK
Indlela yomqondiso > > i-enzyme ye-metabolic / iprotease > > i-MMP

Ekujoliswe kuko:MMP9
NF-kB
p38 MAPK

Isifundo se-in vitro:I-isorlicin inokuthintela ngokufanelekileyo umsebenzi we-gelation we-MMP-9 we-PMA eyenziwe ngeeseli ze-HT1080.I-Isoglycyrrhizin apigenin inciphisa ukwanda kwemveliso ye-MMP-9 kwiiseli ze-HT1080 ezenziwe yi-PMA, inamandla e-anti metastasis kunye ne-anti angiogenesis kwiiseli ezinobungozi kunye neeseli ze-endothelial, kwaye ayinayo i-cytotoxicity [1].

Isalathiso:[1].UKim A1, et al.Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells.Front Pharmacol.2018 Dec 10;9:1455.

Iimpawu zePhysicochemical ye-Isoliquiritin Apioside

Ubuninzi: 1.6 ± 0.1 g / cm3

Indawo yokubilisa: 901.0 ± 65.0 ° C kwi-760 mmHg

Ifomula yemolekyuli: c26h30o13

Ubunzima bemolekyuli: 550.509

Indawo edanyazayo: 301.9 ± 27.8 ° C

Ubunzima obuchanekileyo: 550.168640

PSA:215.83000

IlogP:1.96

Uxinzelelo lomphunga: 0.0 ± 0.3 mmHg ku-25 ° C

Isalathiso seRefractive: 1.709

Igama lesiNgesi le-Isoliquiritin Apioside

I-2-Propen-1-enye, 1- (2,4-dihydroxyphenyl) -3-[4-[[2-O-[(2S,3R,4R))-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl )-2-furanyl]-β-D-glucopyranosyl]oxy]phenyl]-, (2E)-

3-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl]phenyl 2-O-[(2S,3R,4R)-3,4-dihydroxy-4 -(hydroxymethyl)tetrahydro-2-furanyl]-β-D-glucopyranoside

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