IMethylophiopogonanone B
Ukusetyenziswa kweMethylophiopogonanone B
I-Methylophiopogonone B, i-isodihydroflavone ephezulu, ekhutshwe kwingcambu ye-Ophiopogon japonicus, inomthamo ophezulu we-antioxidant.I-Methylophiopogonone B inyusa i-GTP i-Rho kwaye isebenza nge-Rho indlela yokubonisa.I-Methylophiopogonone B yenza utshintsho lwe-cell morphological, kubandakanywa ukunyanzeliswa kwe-dendritic kunye noxinzelelo lwe-fiber formation, ngokuhlengahlengiswa kwe-actin cytoskeleton.
Igama leMethylophiopogonanone B
Igama lesiNgesi:
(3R) -5,7-Dihydroxy-3-(4-methoxybenzyl)-6,8-dimethyl-2,3-dihydro-4 H-chromen-4-enye
Umsebenzi webhayoloji weMethylophiopogonanone B
Inkcazo: i-methylophiopogonone B, i-isodihydroflavone ephezulu, ekhutshwe kwingcambu ye-Ophiopogon japonicus, inomthamo ophezulu we-antioxidant.I-Methylophiopogonone B inyusa i-GTP i-Rho kwaye isebenza nge-Rho indlela yokubonisa.I-Methylophiopogonone B yenza utshintsho lwe-cell morphological, kubandakanywa ukunyanzeliswa kwe-dendritic kunye noxinzelelo lwe-fiber formation, ngokuhlengahlengiswa kwe-actin cytoskeleton.
Iindidi ezinxulumeneyo: intsimi yophando > > enye
indlela yomqondiso > > Iprotheyini ye-G edityaniswe ne-receptor /
G protein > > RAS
Iimbekiselo: [1] Wang Y, et al.I-Homoisoflavonoids kunye ne-Antioxidant
Umsebenzi weOphiopogon japonicus Root.
Ito Y, et al.I-arhente yenoveli, i-methylophiopogonanone B,
ikhuthaza ukusebenza kwe-Rho kunye ne-tubulin depolymerization.IMol Cell Biochem.2007 Mar;297(1-2):121-9.Epub 2006 Oct 7.
Iimpawu zePhysicochemical zeMethylophiopogonanone B
Ubuninzi: 1.285
Indawo yokuBilisa: 554.5 ± 49.0 ° C kwi-760 mmHg
Ifomula yemolekyuli: C19H20O5
Ubunzima bemolekyuli: 328.359
Indawo edanyazayo: 201.5 ± 23.3 ° C
Ubunzima obuchanekileyo: 328.131073
PSA: 75.99000
IlogP: 5.22
Uxinzelelo lomphunga: 0.0 ± 1.6 mmHg ku-25 ° C
Isalathiso se-refractive: 1.617
Inkonzo Yongjian
Inkonzo eCwangcisiweyo yeZixhobo zeNgcaciso zeMichiza yezamayeza zesiNtu zamaTshayina
I-Jiangsu Yongjian Pharmaceutical Technology Co., Ltd. ibandakanyeka ikakhulu kuphando olusisiseko lwezinto ezisebenzayo zamayeza esintu amaTshayina ngaphezulu kweminyaka elishumi.Ukuza kuthi ga ngoku, inkampani yenze uphando olunzulu kwiintlobo ezingaphezu kwe-100 zamayeza esintu aqhelekileyo asetyenziswa eTshayina, kwaye yakhupha amawaka eekhemikhali.
Inkampani inabasebenzi abaphezulu be-R & D kunye novavanyo olugqibeleleyo kunye nezixhobo zokuhlalutya kushishino, kwaye ikhonze amakhulu amaziko ophando lwezenzululwazi.Inokukhawuleza kwaye ihlangabezane neemfuno zabathengi
Ukwahlulwa kokungcola kweziyobisi, ukuLungisa kunye neNkonzo yokuQinisekisa uLwakhiwo
Ukungcola kwiziyobisi kuhambelana ngokusondeleyo nomgangatho, ukhuseleko kunye nokuzinza kwamachiza.Ukulungiswa kunye nokuqinisekiswa kwesakhiwo sokungcola kwiziyobisi kunokusinceda siqonde iindlela zokungcola kunye nokubonelela ngesiseko sokuphucula inkqubo yokuvelisa.Ngoko ke, ukulungiswa kunye nokwahlula ukungcola kubaluleke kakhulu kuphando lweziyobisi kunye nophuhliso.
Nangona kunjalo, umxholo wokungcola kwiyeza liphantsi, umthombo ubanzi, kwaye isakhiwo sininzi sifana necandelo eliphambili.Yeyiphi itekhnoloji enokusetyenziswa ukwahlula kunye nokucoca bonke ukungcola kwichiza nganye nganye kwaye ngokukhawuleza?Zeziphi iindlela neendlela ezisetyenziswayo ukuqinisekisa ubume bobu kungcola?Obu bubunzima kunye nomngeni ojongene namacandelo amaninzi oxubo mayeza, ngakumbi amashishini axuba amayeza ezityalo kunye namayeza elungelo elilodwa lomenzi wechina.
Ngokusekwe kwiimfuno ezinjalo, inkampani iye yasungula ukwahlulwa kokungcola kweziyobisi kunye neenkonzo zokucoca.Ukuxhomekeka kwi-resonance yamagnetic yenyukliya, i-spectrometry yobunzima kunye nezinye izixhobo kunye nobuchwepheshe, inkampani inokuchonga ngokukhawuleza ukwakheka kweekhompawundi ezahluliweyo, ukuze ihlangabezane neemfuno zabathengi.
SPF Animal Experiment
Indawo yolwakhiwo yendawo yovavanyo lwezilwanyana yi-1500 square metres, kubandakanywa i-400 square metres yendawo yovavanyo yenqanaba le-SPF kunye ne-100 yeemitha zesikwere selebhu yenqanaba le-P2 yeseli.Ikhokelwe ngoosonzululwazi base China Pharmaceutical University, yenza iqela lobugcisa elingundoqo elinenani lababuyileyo.Ukubonelela ngeemodeli zezilwanyana ezikumgangatho ophezulu, uyilo lokulinga, iiprojekthi zizonke kunye nezinye iinkonzo zophando lwenzululwazi yebhayoloji, ukufundisa kunye nophuhliso lwemizimveliso.
Umda woShishino
1. Ukutyisa izilwanyana ezincinci
2. Imodeli yezifo zezilwanyana
3. Ukunikezelwa kweprojekthi yasekholejini
4. Uvavanyo lwe-Pharmacodynamic kwi-vivo
5. Uvavanyo lwe-Pharmacokinetic
6. Inkonzo yokulinga iseli yethumba
Amandla Ethu
1. Gxininisa kwimifuniselo yokwenyani
2. Qinisekisa ngokungqongqo inkqubo
3. Utyikitye ngokungqongqo isivumelwano semfihlo
4. Ilabhoratri yeyakho ngaphandle kwamakhonkco aphakathi
5. Iqela lobugcisa lobuchwephesha liqinisekisa umgangatho wokulinga
Imekobume yovavanyo ye-SPF, ukondla umntu owabelwe ngokukhethekileyo, ukulandelela ixesha lokwenyani inkqubela yovavanyo
