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Iimveliso

Naringenin Cas No. 480-41-1

Inkcazelo emfutshane:

I-Naringenin yi-organic compound yendalo kunye ne-molecular formula c15h12o5.Ngumgubo omthubi, onyibilika kwi-ethanol, ether kunye nebenzene.Idyasi yembewu isuka ikakhulu kwicashew nuts of lacqueraceae.Isetyenziselwa uhlalutyo lomgangatho kunye nobungakanani bamayeza emveli aseTshayina aqulethe i-naringin [1].Kwi-7 carbon position, yenza i-glycoside ene-neohesperidin, ebizwa ngokuba yi-naringin.Inencasa ekrakrayo.Xa iikhompawundi ze-dihydrochalcone zenziwe ngokuvulwa kweringi kunye ne-hydrogenation phantsi kweemeko ze-alkaline, i-sweetener enobumnandi obufikelela kuma-2000 amaxesha e-sucrose.I-Hesperidin ininzi kwi-orenji peel.Yenza i-glycoside kunye ne-rutin kwindawo ye-7 ye-carbon, ebizwa ngokuba yi-hesperidin, kwaye yenza i-glycoside kunye ne-rutin kwindawo ye-7 carbon β-Neohesperidin yi-glycoside ye-neohesperidin.


Iinkcukacha zeMveliso

Iithegi zeMveliso

Intshayelelo emfutshane

Inkqubo yokuvelisa:ikakhulu igqitywe ngokutsalwa kotywala, ukutsalwa, ukukrolwa kwechromatography, icrystallization kunye nezinye iinkqubo.

Inombolo yeCas.480-41-1

Isiqulatho senkcazo:98%

Indlela yovavanyo:HPLC

Ubume bemveliso:ikristale emhlophe ye-acicular, umgubo ocolekileyo.

Iimpawu zomzimba kunye neekhemikhali:Inyibilika kwi-acetone, i-ethanol, i-ether kunye ne-benzene, phantse ayinyibiliki emanzini.Ukusabela kwe-magnesium hydrochloride powder kwakuyi-cherry ebomvu, impendulo ye-sodium tetrahydroborate yayibomvu ebomvu, kwaye impendulo ye-molish yayingalunganga.

Beka ubomi kwishelufa:Iminyaka emi-2 (yethutyana)

Umthombo weMveliso

I-Amacardi um occidentale L. ingundoqo kunye neqokobhe leziqhamo, njl.Prunus yedoensis mats Bud, Mei P. mumesiebet Zucc Bud.

Isenzo se-Pharmacological

I-Naringin yi-aglycone ye-naringin kwaye yeye-dihydroflavonoids.Inemisebenzi ye-antibacterial, anti-inflammatory, free radical scavenging, i-antioxidant, ukukhohlela kunye ne-expectorant, ukunciphisa i-lipid yegazi, i-anti-cancer, i-anti-tumor, i-antispasmodic kunye ne-cholagogic, ukuthintela kunye nokunyangwa kwezifo zesibindi, inhibition ye-platelet coagulation, i-anti. i-atherosclerosis kunye nokunye.Ingasetyenziswa ngokubanzi kumayeza, ukutya kunye namanye amasimi.

I-antibacterial
Inefuthe elinamandla le-antibacterial kwi-Staphylococcus aureus, i-Escherichia coli, i-dysentery kunye ne-typhoid bacillus.I-Naringin nayo inefuthe kwifungi.Ukutshiza i-1000ppm kwirayisi kunokunciphisa usulelo lweMagnaporthe grisea ngama-40-90%, kwaye ayinayo ityhefu ebantwini nakwimfuyo.

I-Antiinflammatory
Iimpuku zazitofwe nge-intraperitoneally nge-20mg / kg yonke imihla, nto leyo eyathintela kakhulu inkqubo yokuvuvukala ebangelwa kukufakelwa kwebhola yoboya.Galati et al.Kwafunyaniswa ukuba iqela ngalinye ledosi ye-naringin linefuthe elichasayo ngokusetyenziswa kwe-tablet yendlebe ye-mouse, kunye ne-anti-inflammatory effect yanda ngokunyuka kwedosi.Izinga lokuthintela iqela le-dose ephezulu laliyi-30.67% kunye nokwahlukana kobunzima kunye ne-38% kunye nokwahlukana kwesisindo.[4] Feng Baomin et al.Isigaba se-3 se-dermatitis esibangelwa kwiimpuku ngendlela ye-DNFB, kwaye emva koko wanika i-naringin ngomlomo kwi-2 ~ 8 iintsuku zokujonga amazinga okuthintela kwisigaba esiphuthumayo (IPR), isigaba sasemva kwexesha (i-LPR) kunye ne-ultra late phase (VLPR).I-Naringin inokuthintela ngokufanelekileyo i-edema yendlebe ye-IPR kunye ne-VLPR, kwaye inexabiso elithile lophuhliso kwi-anti-inflammatory.

Ulawulo lwamajoni omzimba
I-Naringin igcina ibhalansi efanelekileyo yoxinzelelo lwe-oxidative ngexesha elithile kunye nemimandla ethile ngokulawula ukuhamba kwee-electron kwi-mitochondria.Ke ngoko, umsebenzi we-immunomodulatory we-naringin wahlukile kwii-immune enhancers eziqhelekileyo okanye i-immunosuppressants.Uphawu lwayo kukuba inokubuyisela i-immune state state (i-pathological state) kwindawo ekufutshane ne-immune balance state (imeko ye-physiological), Esikhundleni sokuphucula unilaterally okanye ukuvimbela impendulo yokuzivikela.

Ummiselo wokuya exesheni kwabasetyhini
I-Naringin inomsebenzi ofanayo namachiza achasene nokudumba.Inokunciphisa i-synthesis ye-prostaglandin PGE2 ngokuvimbela i-cyclooxygenase Cox, kwaye idlale indima ye-antipyretic, i-analgesic kunye nokunciphisa ukuvuvukala.
Ngokusekwe kwi-estrogen efana nesiphumo se-naringin, i-naringin inokusetyenziselwa unyango lokubuyisela i-estrogen kubasetyhini abasemva kokuya exesheni ukunqanda ukuchaphazeleka okumandundu okubangelwa kukusetyenziswa kwexesha elide kwe-estrogen.

Iziphumo zokutyeba
I-Naringin inefuthe elicacileyo lonyango kwi-hyperlipidemia kunye nokutyeba.
I-Naringin inokuphucula kakhulu i-plasma ye-cholesterol concentration, i-TG (triglyceride) i-concentration kunye ne-free-fatty concentration ye-asidi kwiigundane ezigqithiseleyo.Kwafunyaniswa ukuba i-naringin inokunyusa ukulawula i-monocyte peroxisome proliferator esebenzayo i-receptor kwimodeli enamafutha aphezulu δ, Ukunciphisa izinga le-lipid yegazi.
Ngokusebenzisa izilingo zeklinikhi, kwafunyaniswa ukuba izigulane ezine-hypercholesterolemia zithatha i-capsule enye ene-400mg i-naringin yonke imihla kwiiveki ezisi-8.Uxinzelelo lwe-TC kunye ne-LDL ye-cholesterol kwi-plasma yehla, kodwa i-TG kunye ne-HDL ye-cholesterol ayizange itshintshe kakhulu.
Ekugqibeleni, i-naringin inokuphucula i-hyperlipidemia, eye yaqinisekiswa kakuhle kwiimvavanyo zezilwanyana kunye nezilingo zeklinikhi.

Ukukhupha ii-radicals zasimahla kunye ne-antioxidation
I-DPPH (i-dibenzo bitter acyl radical) yi-stable free radical.Ukukwazi ukukhupha iiradicals zasimahla kunokujongwa yi-517 nm absorbance attenuation.[6] I-Kroyer yafunda i-antioxidant effect ye-naringin ngokusebenzisa iimvavanyo kwaye yaqinisekisa ukuba i-naringin ine-antioxidant effect.[7] Zhang Haide et al.Uvavanye inkqubo ye-lipid peroxidation ye-LDL nge-colorimetry kunye nokukwazi ukuthintela ukuguqulwa kwe-oxidative ye-LDL.I-Naringin ikakhulu i-chelates i-Cu2 + ngokusebenzisa i-3-hydroxyl kunye ne-4-carbonyl amaqela, okanye ibonelela ngeproton kunye ne-radical neutralization yamahhala, okanye ikhusela i-LDL kwi-lipid peroxidation ngokusebenzisa i-self oxidation.U-Zhang Haide kunye nabanye bafumanisa ukuba i-naringin inefuthe elihle lokukhupha i-radical free ngendlela ye-DPPH.Isiphumo sasimahla se-radical scavenging sinokubonwa yi-hydrogen oxidation ye-naringin ngokwayo.[8] Peng Shuhui et al.Kusetyenziswe imodeli yokulinga yokukhanya kwe-riboflavin (IR) - i-nitrotetrazolium chloride (NBT) - i-spectrophotometry ukubonisa ukuba i-naringin inomphumo ocacileyo wokukhupha kwiintlobo ze-oksijini ezisebenzayo i-O2 -, enamandla kune-ascorbic acid ekulawuleni okulungileyo.Iziphumo zovavanyo lwezilwanyana zibonise ukuba i-naringin yayinempembelelo enamandla yokuthintela kwi-lipid peroxidation kwingqondo yempuku, intliziyo kunye nesibindi, kwaye inokuphucula kakhulu umsebenzi we-superoxide dismutase (SOD) kwigazi lempuku.

Ukukhuselwa kwentliziyo
I-Naringin kunye ne-naringin inokunyusa imisebenzi ye-acetaldehyde reductase (ADH) kunye ne-acetaldehyde dehydrogenase (ALDH), ukunciphisa imixholo ye-triglycerides kwisibindi kunye ne-cholesterol epheleleyo egazini kunye nesibindi, ukwandisa umxholo we-high density lipoprotein cholesterol (HDLC), ukwandisa umlinganiselo. ye-HDLC kwi-cholesterol epheleleyo, kunye nokunciphisa i-atherogenic index ngexesha elifanayo, i-Naringin inokukhuthaza ukuthuthwa kwe-cholesterol kwi-plasma ukuya kwisibindi, i-bile secretion kunye ne-excretion, kwaye inqanda ukuguqulwa kwe-HDL kwi-VLDL okanye i-LDL.Ngoko ke, i-naringin inokunciphisa umngcipheko we-arteriosclerosis kunye nesifo senhliziyo.I-Naringin inokunciphisa umxholo we-cholesterol epheleleyo kwi-plasma kwaye yomeleze imetabolism yayo.

Isiphumo se-Hypolipidemic
UZhang Haide et al.Uvavanyo lwe-serum cholesterol (TC), i-low density lipoprotein cholesterol (LDL-C), i-plasma high density lipoprotein cholesterol (HDL-C), triglyceride (TG) kunye nezinye izinto zeegundane emva kokulawulwa kwe-intravenous ngokusebenzisa iimvavanyo zezilwanyanaIziphumo zibonise ukuba i-naringin inokunciphisa kakhulu. i-serum TC, TG kunye ne-LDL-C kunye nokwandisa i-serum HDL-C kwi-dose ethile, ebonisa ukuba i-naringin ibe nefuthe lokunciphisa i-lipid yegazi kwiimpuku.[

Umsebenzi we-Antitumor
I-Naringin inokulawula ukusebenza komzimba kunye nokuthintela ukukhula kwe-tumor.I-Naringin inomsebenzi kwi-rat leukemia L1210 kunye ne-sarcoma.Iziphumo zibonise ukuba umlinganiselo we-thymus / wobunzima bomzimba weempuku unyukile emva kokulawulwa komlomo we-naringin, nto leyo ebonisa ukuba i-naringin inokuphucula ukusebenza komzimba.I-Naringin inokulawula inqanaba le-T lymphocytes, ilungise ukusilela komzimba okwesibini okubangelwa lithumba okanye iradiotherapy kunye nechemotherapy, kunye nokuphucula isiphumo sokubulala iiseli zomhlaza.Kuxelwe ukuba i-naringin inokonyusa ubunzima be-thymus kwi-ascites ezinomhlaza eziphethe iimpuku, icebisa ukuba inokuphucula ukusebenza kwamajoni omzimba kwaye ihlanganise amandla ayo angaphakathi okuchasana nomhlaza.Kwafunyaniswa ukuba i-pomelo peel extract ine-inhibitory effect kwi-S180 sarcoma, kunye ne-tumor inhibition rate yi-29.7%.

Antispasmodic kunye cholagogic
Inefuthe elinamandla kwi-flavonoids.I-Naringin nayo inefuthe elinamandla ekwandiseni i-bile secretion yezilwanyana zokulinga.

I-Antitussive kunye ne-Expectorant Effect
Ukusebenzisa i-phenol ebomvu njengesalathisi sokuphelisa isifo, uvavanyo lubonisa ukuba i-naringin inokhohlokhohlo olunamandla kunye nesiphumo se-expectorant.

Isicelo seKlinikhi
Isetyenziselwa ukunyanga usulelo lwebhaktiriya, i-sedative kunye ne-anticancer.
Ifomu yedosi yesicelo: i-suppository, i-lotion, inaliti, ithebhulethi, i-capsule, njl.


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