Obtusin
Ukusetyenziswa kwe-Obtusin
I-Obtusin, evela kwimbewu ye-cassia, i-inhibitor ekhethiweyo kakhulu kwaye inokhuphiswano lomntu we-monoamine oxidase-A (hmao-a), kunye ne-IC50 ye-11.12 μ M. Ki yi-6.15.I-Obtusin idlala indima yokuthintela kwizifo ze-neurodeergenerative, ngakumbi ukuxhalaba kunye nokudakumba.
Igama lika-Obtusin
Igama lesiNgesi: Obtusin
I-Bioactivity ye-Obtusin
Inkcazo: i-obtusin ivela kwimbewu ye-cassia.I-inhibitor ekhethiweyo kakhulu kunye nokhuphiswano lwe-monoamine oxidase-A (hmao-a), kunye ne-IC50 ye-11.12 μ M. Ki yi-6.15.I-Obtusin idlala indima yokuthintela kwizifo ze-neurodeergenerative, ngakumbi ukuxhalaba kunye nokudakumba.
Iindidi ezinxulumeneyo: indlela yomqondiso > > indlela yomqondiso we-neural > > i-monoamine oxidase
Inkalo yophando > > izifo ze-neurological
Ithagethi: IC50: 11.12 μ M (hMAO-A)[1] Ki: 6.15 (hMAO-A)[1]
Iimbekiselo: [1] Paudel P, et al.Kwi-Vitro nakwi-Silico Human Monoamine Oxidase Inhibitory Potential of Anthraquinones, Naphthopyrones, kunye neNaphthalenic Lactones esuka kwiCassia obtusifolia Linn Seeds.ACS Omega.2019 Septemba 18;4(14):16139-16152.
Iimpawu zePhysicochemical of Obtusin
Ubuninzi: 1.4 ± 0.1 g / cm3
Indawo yokuBilisa: 614.9 ± 55.0 ° C kwi-760 mmHg
Ifomula yemolekyuli: c18h16o7
Ubunzima beMolekyuli: 344.315
Indawo edanyazayo: 227.0 ± 25.0 ° C
Ubunzima obuchanekileyo: 344.089600
PSA:102.29000
IlogP:4.10
Uxinzelelo lomphunga: 0.0 ± 1.8 mmHg ku-25 ° C
Refractive Index: 1.634
Ulwazi loKhuseleko lwe-Obtusin
Ikhowudi yeCustoms: 2914690090
Uncwadi: uCameron, uDonald W;Feutrill, uGeoffrey I.;Gamble, Glenn B.;Stavrakis, John Tetrahedron Iileta, 1986, vol.27, # 41 p.4999 - 5002
Obtusin Customs
Ikhowudi yeCustoms: 2914690090
Isishwankathelo saseTshayina: Isishwankathelo saseTshayina
Ushwankathelo:2914690090 ezinye iiquinones
Igama lesiNgesi leSiko
I-9,10-Anthracenedione, i-1,7-dihydroxy-2,3,8-trimethoxy-6-methyl-
I-1,7-dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione
I-1,7-Dihydroxy-2,3,8-trimethoxy-6-methyl-9,10-anthraquinone
Ulawulo loMgangatho weMveliso
1. Inkampani ithenge i-nuclear magnetic resonance (i-Bruker 400MHz) i-spectrometer, i-liquid phase mass spectrometer (LCMS), i-gas phase mass spectrometer (GCMs), i-mass spectrometer (amanzi SQD), iichromatographs ezizenzekelayo zolwelo olusebenza ngokuphindaphindiweyo, iichromatographs zolwelo olulungiselelayo, njl. .
2. Inkampani igcina intsebenziswano esondeleyo kunye noqhagamshelwano namaziko ophando lwezenzululwazi afana ne-Shanghai Institute yokulawula iziyobisi, iqonga lenkonzo yoluntu yaseNanjing biomedical kunye neziko lohlalutyo kunye novavanyo lwe-Shanghai Pharmaceutical Industry Research Institute.
3. Inkampani iqhuba ngokukhutheleyo isiqinisekiso sovavanyo lwelabhoratri yomntu wesithathu, kwaye kulindeleke ukuba ifumane iSatifikethi sokuVunywa kweLabhoratri ye-CNAs ngo-2021.
