Isoliquiritin Apioside
Ohun elo ti Isoliquiritin Apioside
Isoliquiritin apioside, paati ti o ya sọtọ lati glycorrhizae redio rhome, ni pataki idinku PMA induced ilosoke ninu iṣẹ MMP9 ati idilọwọ PMA induced MAPK ati NF-κ B imuṣiṣẹ.Isoliquitin apioside ṣe idiwọ ikọlu ati angiogenesis ti awọn sẹẹli alakan ati awọn sẹẹli endothelial.
Orukọ Isoliquiritin Apioside
Orukọ Kannada:Isoliquiritin Apioside
Orukọ Gẹẹsi:(E) -3-[4-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R) -3,4-dihydroxy-4- (hydroxymethyl) oxolan-2-yl] oxy-4,5-dihydroxy-6- (hydroxymethyl) oxan-2-yl] oxyphenyl] -1- (2,4-dihydroxyphenyl) prop-2-en-1-ọkan
Bioactivity ti Isoliquiritin Apioside
Apejuwe:isoliquitin apioside, paati ti o ya sọtọ lati glycorrhizae redio rhome, ni pataki idinku PMA induced ilosoke ninu iṣẹ MMP9 ati idilọwọ PMA induced MAPK ati NF-κ B imuṣiṣẹ.Isoliquitin apioside ṣe idiwọ ikọlu ati angiogenesis ti awọn sẹẹli alakan ati awọn sẹẹli endothelial.
JẹmọCawọn ile-ẹkọ:aaye iwadi > > akàn
Ona ifihan agbara>> MAPK / Ona ifihan agbara ERK> p38 MAPK
Ona ifihan agbara>> enzymu ti iṣelọpọ / protease> MMP
Àfojúsùn:MMP9
NF-κB
p38 MAPK
Iwadi inu vitro:isorlicin le ṣe idiwọ iṣẹ ṣiṣe MMP-9 gelation ni imunadoko ti awọn sẹẹli HT1080 ti o fa PMA.Isoglycyrrhizin apigenin dinku ilosoke ti iṣelọpọ MMP-9 ninu awọn sẹẹli HT1080 ti o fa nipasẹ PMA, ni agbara ti anti metastasis ati anti angiogenesis ninu awọn sẹẹli tumo buburu ati awọn sẹẹli endothelial, ko si ni cytotoxicity [1].
Itọkasi:[1].Kim A1, et al.Isoliquiritin Apioside Npa in vitro Invasiveness ati Angiogenesis ti Awọn sẹẹli Akàn ati Awọn sẹẹli Endothelial.Pharmacol iwaju.Ọdun 2018 Oṣu kejila 10;9:1455.
Awọn ohun-ini kẹmika ti Isoliquiritin Apioside
iwuwo: 1.6 ± 0.1 g / cm3
Ojutu farabale: 901.0 ± 65.0 ° C ni 760 mmHg
Ilana molikula: c26h30o13
Molikula àdánù: 550.509
Aaye filasi: 301.9 ± 27.8 ° C
Iwọn deede: 550.168640
PSA: 215.83000
LogP: 1.96
Titẹ titẹ: 0.0 ± 0.3 mmHg ni 25 ° C
Refractive atọka: 1.709
English inagijẹ ti Isoliquiritin Apioside
2-Propen-1-ọkan,1- (2,4-dihydroxyphenyl) -3-[4-[[2-O-[(2S,3R,4R) -tetrahydro-3,4-dihydroxy-4- (hydroxymethyl). -2-furanyl] -β-D-glucopyranosyl] oxy] phenyl] -, (2E)
3- [(1E) -3- (2,4-Dihydroxyphenyl) -3-oxo-1-propen-1-yl] phenyl 2-O-[(2S,3R,4R) -3,4-dihydroxy-4 (hydroxymethyl) tetrahydro-2-furanyl]-β-D-glucopyranoside.
Neolicuroside
