Ophiopogonin D Cas No.945619-74-9
Ophiopogon Saponin D Name
Orukọ Gẹẹsi:(1β,3β,25R) -3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl- (1-> 2)-[β-D-xylopyranosyl- (1-> 3)] -6-deoxy-β-D-galactopyranoside
Bioactivity ti Ophiopogon Japonicus Saponin D
Apejuwe:Ophiopogon D jẹ adayeba toje C29 sitẹriọdu glycoside ti o ya sọtọ lati isu ti Ophiopogon japonicus.Ophiopogonin D jẹ olupilẹṣẹ CYP2J3 ti o mu ki CYP2J2 / eets ati PPAR pọ si ninu awọn sẹẹli endothelial iṣọn iṣọn eniyan (HUVECs) α Ifihan ti Ang II ṣe idiwọ Ang II ti o fa NF-κ B iyipada iparun, I κ B α Down ilana, + intracellular apọju ati imuṣiṣẹ ti awọn cytokines proinflammatory.A ti lo Ophiopogonin D lati tọju iredodo ati awọn arun inu ọkan ati ẹjẹ fun ẹgbẹẹgbẹrun ọdun.
Awọn ẹka ti o yẹ
Ona ifihan agbara > > gbigbe transmembrane > > ikanni kalisiomu
Aaye iwadi > > Arun inu ọkan ati ẹjẹ
Ona ifihan agbara > > Yiyipo sẹẹli / ibajẹ DNA> PPAR
Aaye iwadi > > igbona / ajesara
Àfojúsùn
PPARA
NF-κB
Ca2+
Awọn iwe Itọkasi:[1].Wang L, et al.Homo-aro-cholestane, furostane ati spirostane saponins lati awọn isu ti Ophiopogonjaponicus.Phytochemistry.Ọdun 2017 Oṣu Kẹrin; 136: 125-132.
[2].Huang X, et al.Ophiopogonin D ati EETs ṣe atunṣe awọn idahun iredodo ti Ang II ṣe nipasẹ ṣiṣiṣẹ PPARA ni awọn HUVECs.Biochem Biophys Res Commun.2017 Oṣu Kẹjọ 19; 490 (2): 123-133.
English Alias of Ophiopogon saponin D
(1β,3β,25R) -3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl- (1-> 2)-[β-D-xylopyranosyl- (1-> 3)] -6-deoxy-β-D-galactopyranoside β-D-Galactopyranoside, (1β,3β,25R) -3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[β-D-xylopyranosyl-(1->3)]-6-deoxy-
(2S,3R,4R,5R,6S)-2-((2R,3R,4S,5S,6R)-5-hydroxy-2-(((4R,5'R,6R,6aR,6bS,8aS ,8bR,9S,10R,11aS,12aS,12bS)-4-hydroxy-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a, 6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2 '-pyran] -6-yl) oxy) -6-methyl-4-((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy) tetrahydro- 2H-pyran-3-yl) oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
Ophiopogonin D
Deacetylophiopogonin C
