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Awọn ọja

Pachymic Acid

Apejuwe kukuru:

Orukọ ti o wọpọ: pachymic acid

CAS No.: 29070-92-6

Iwọn Molikula: 528.763

iwuwo: 1.1 ± 0.1 g / cm3

Ojuami Sise: 612.2 ± 55.0 ° C ni 760 mmHg

Ilana molikula: C33H52O5

Oju Iyọ: n / A

MSDS: N/A

Ojuami Filasi: 184.7 ± 25.0 ° C


Alaye ọja

ọja Tags

Ohun elo ti Pachymic Acid

Pachymic acid jẹ triterpenoid lati P. cocos.Pachymic acid ṣe idiwọ awọn ipa ọna ifihan Akt ati ERK.

Orukọ Pachymic Acid

Orukọ Kannada: Poria acid

Orukọ Gẹẹsi: pachymic acid

Chinese inagijẹ: Poria acid Fulvic acid

Bioactivity ti Pachymic Acid

Apejuwe:
pachymic acid jẹ triterpenoid lati P. cocos.Pachymic acid ṣe idiwọ awọn ipa ọna ifihan Akt ati ERK.

Awọn ẹka ti o jọmọ:
aaye iwadi > > akàn
Awọn ọja Adayeba > > terpenoids ati glycosides

Àfojúsùn:
Akt
ERK

Ninu Ikẹkọ Vitro:
pachymic acid (PA) le ṣe idiwọ tumorigenesis ti akàn gallbladder ti o kan Akt ati awọn ipa ọna ifihan ERK.Itọju Pachymic acid (PA) ṣe idiwọ ni pataki Rho a, Akt ati awọn ipa ọna ERK ni awọn sẹẹli alakan gallbladder.Itọju Pachymic acid (PA) le dinku PCNA, ICAM-1, RhoA, p-Akt ati perk ni ọna ti o gbẹkẹle iwọn lilo.Awọn wakati 12 lẹhin itọju, 10 μ G / milimita Poria acid (PA) ṣe idiwọ idagbasoke sẹẹli ni ifọkansi ti 30 μ G / milimita siwaju dinku idagbasoke sẹẹli.Idagba sẹẹli jẹ idinamọ ni akoko kan - ati ọna ti o gbẹkẹle iwọn lilo.Lẹhin awọn wakati 48 ti itọju, ifọkansi jẹ 10 μ g / mL, 20 μ G / milimita ati 30 μ Pachymic acid (PA) ni g / milimita ṣe idiwọ idagbasoke sẹẹli nipasẹ 25%, 40% ati 70%.Pachymic acid (PA) tun ṣe idiwọ idagba awọn sẹẹli alakan gallbladder ni akoko ti o gbẹkẹle ati ọna ti o gbẹkẹle iwọn lilo [1].

Ninu Ikẹkọ Vivo:
lati le ṣe iṣiro iṣẹ antitumor ti pachymic acid (PA) ni vivo, akàn ẹdọfóró eniyan nci-h23 tumor xenograft awoṣe ti lo.Pachymic acid (PA) ṣe idiwọ idagbasoke tumo ni pataki ni awọn iwọn 30 ati 60 mg / kg fun awọn ọjọ 21 ni akawe pẹlu ẹgbẹ iṣakoso [2].

Idanwo sẹẹli:
ohun elo kika sẹẹli-8 (CCK-8) ni a lo lati ṣe iṣiro ipa ilodisi ti pachymic acid (PA) lori awọn sẹẹli GBC-SD.Ni kukuru, lẹhin itọju kan pato, ṣafikun 10 si iho kọọkan μ Lcck-8 ojutu, ati lẹhin idabobo kan, a ṣe iwọn gbigba ni 450 nm nipa lilo oluka microplate [1].

Idanwo eranko:
eku [2] lo awọn eku ihoho abo athymic ti ọjọ ori 4-5 ọsẹ.Awọn sẹẹli nci-h23 ti o dagba ni pataki (ni 100 μ 5 ni LPBs × 106) itasi abẹlẹ ni apa ọtun ti asin kọọkan.Tumor xenografts ti dagba si iwọn apapọ ti 100-200mm 3 ati laileto sọtọ si awọn ẹgbẹ itọju mẹrin ti o yatọ (6 eku ni ẹgbẹ kọọkan): (a) iṣakoso ọkọ (0.1% DMSO ni saline deede);(b) Pachymic acid (PA) 10 mg / kg;(c) PA 30 mg / kg;(Dd) PA 60mg / kg.Iwọn tumo ni a wọn lori awọn aake meji pẹlu iranlọwọ ti vernier caliper, ati iwọn didun tumo (mm3) ti ṣe iṣiro.

Itọkasi:
[1].Chen Y, et al.Pachymic acid ṣe idiwọ tumorigenesis ninu awọn sẹẹli carcinoma gallbladder.Int J Clin Exp Med.2015 Oṣu Kẹwa 15; 8 (10): 17781-8.
[2].Ma J, et al.Pachymic acid nfa apoptosis ṣiṣẹ nipasẹ ṣiṣe ROS-ti o gbẹkẹle JNK ati awọn ipa ọna aapọn ER ni awọn sẹẹli akàn ẹdọfóró.Akàn Ẹjẹ Int.Ọdun 2015 Oṣu Kẹjọ 5;15:78.

Awọn ohun-ini Kemikali ti Pachymic Acid

iwuwo: 1.1 ± 0.1 g / cm3

Ojuami Sise: 612.2 ± 55.0 ° C ni 760 mmHg

Ilana molikula: C33H52O5

Iwọn Molikula: 528.763

Ojuami Filasi: 184.7 ± 25.0 ° C

Gangan Ibi: 528.381470

PSA: 83.83000

Wọle: 8.59

Irisi: funfun lulú

Titẹ Nya si: 0.0 ± 4.0 mmHg ni 25 ° C

Atọka itọka: 1.540

English inagijẹ Pachymic Acid

pachimic acid

Lanost-8-en-21-oic acid, 3- (acetyloxy) -16-hydroxy-24-methylene-, (3β,16α)

3-O-Acetyltumulosic acid

3-ACETYLTUMULOSIC ACID

Lanost-8-en-21-oicacid,3- (acetyloxy)-16-hydroxy-24-methylene-,(3beta,16alpha)

(3β,16α)-3-Acetoxy-16-hydroxy-24-methylenelanost-8-en-21-oic acid

Lanost-8-en-21-oic acid,3- (acetyloxy) -16-hydroxy

Lanost-8-en-21-oic acid,3- (acetyloxy) -16-hydroxy


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