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Imikhiqizo

i-methyl rosmarinate

Incazelo emfushane:

Igama Elivamile: i-methyl rosmarinate

Inombolo ye-CAS: 99353-00-1

Isisindo se-Molecular: 374.341

Ukuminyana: 1.5 ± 0.1 g / cm3

Indawo yokubilisa: 655.4 ± 55.0 ° C ku-760 mmHg

I-Molecular Formula: C19H18O8

I-Melting Point: n / A

I-MSDS: N/A

I-Flash Point: 236.5 ± 25.0 ° C


Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Ukusetshenziswa kweMethyl Rosmarinate

I-Methyl rosmarinate iyi-tyrosinase inhibitor engancintisani ehlukanisiwe ne-Rabdosia serra.Ivelu yayo ye-IC50 ye-mushroom tyrosinase ingu-0.28 mm, futhi ingavimbela i-a-glucosidase [1].

Igama likaMethyl Rosmarinate

Igama lesiShayina: Methyl rosmarinate

Umsebenzi Webhayoloji We-Methyl Rosmarinate

Incazelo:

I-Methyl rosmarinate iyi-tyrosinase inhibitor engancintisani ehlukanisiwe ne-Rabdosia serra.Ivelu yayo ye-IC50 ye-mushroom tyrosinase ingu-0.28 mm, futhi ingavimbela i-a-glucosidase [1]

Izigaba Ezihlobene: inkundla yocwaningo > > okunye

indlela yokubonisa > > i-enzyme ye-metabolic / i-protease

>> tyrosinase

Ithagethi: IC50: 0.28 mM (mushroom tyrosinase), a -glucosidase[1]

Inkomba:[1].Lin L, nabanye.Ukuhlolwa okuqhathaniswayo kwe-rosmarinic acid, i-methyl rosmarinate ne-pedalitin ehlukanisiwe ne-Rabdosia serra (MAXIM.) HARA njengama-inhibitors e-tyrosinase ne-α-glucosidase.Ukudla Chem.2011 Dec 1;129(3):884-9.

Izakhiwo zePhysicochemical zeMethyl Rosmarinate

Ukuminyana: 1.5 ± 0.1 g / cm3

Indawo yokubilisa: 655.4 ± 55.0 ° C ku-760 mmHg

I-Molecular Formula: c19h18o8

Isisindo se-Molecular: 374.341

I-Flash Point: 236.5 ± 25.0 ° C

IMisa Eliqondile: 374.100159

I-PSA: 133.52000

I-logP:2.12

I-Steam Pressure: 0.0 ± 2.0 mmHg ku-25 ° C

Inkomba ye-Refractive: 1.668

I-Alias ​​yesiNgisi Yezakhiwo ze-Methyl Rosmarinate

(2R)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate

(2R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxo-2-propanyl (2E)-3-(3,4-dihydroxyphenyl)acrylate

I-Benzenepropanoic acid, α--[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-, i-methyl ester, (αR)-

Isevisi ye-Yongjian

Isevisi Eyenziwe Ngezifiso Yezikhombo Zezinto Zemithi Yendabuko YamaShayina
I-Jiangsu Yongjian Pharmaceutical Technology Co., Ltd. ibambe iqhaza kakhulu ocwaningweni oluyisisekelo lwezinto ezisebenzayo zemithi yendabuko yamaShayina iminyaka engaphezu kweyishumi.Kuze kube manje, inkampani yenze ucwaningo olunzulu ngezinhlobo ezingaphezu kwe-100 zemithi yendabuko yaseShayina evame ukusetshenziswa, futhi yakhipha izinkulungwane zezingxenye zamakhemikhali.

Inkampani inabasebenzi abaphezulu be-R & D kanye nemishini yokuhlola nokuhlaziya ephelele embonini, futhi isize amakhulu ezikhungo zocwaningo lwesayensi.Ingakwazi ukuhlangabezana nezidingo zamakhasimende ngokushesha nangempumelelo

Ukwehlukaniswa Kokungcola Kwezidakamizwa, Isevisi Yokulungiselela kanye Nesakhiwo Sokuqinisekisa
Ukungcola kwezidakamizwa kuhlobene kakhulu nekhwalithi, ukuphepha kanye nokuzinza kwezidakamizwa.Ukulungiswa nokuqinisekiswa kwesakhiwo sokungcola emithini kungasisiza siqonde izindlela zokungcola futhi kunikeze isisekelo sokuthuthukisa inqubo yokukhiqiza.Ngakho-ke, ukulungiswa nokuhlukaniswa kokungcola kubaluleke kakhulu ocwaningweni nasekuthuthukisweni kwezidakamizwa.

Kodwa-ke, okuqukethwe kokungcola emthini kuphansi, umthombo ubanzi, futhi isakhiwo sifana kakhulu nengxenye eyinhloko.Yibuphi ubuchwepheshe obungasetshenziswa ukuhlukanisa nokuhlanza konke ukungcola emthini ngamunye ngamunye futhi ngokushesha?Yiziphi izindlela nezindlela ezisetshenziswayo ukuze kuqinisekiswe ukwakheka kwalokhu kungcola?Lobu ubunzima kanye nenselelo ebhekene namayunithi amaningi emithi, ikakhulukazi amabhizinisi emithi yezitshalo kanye nemithi yobunikazi yamaShayina.

Ngokusekelwe ezidingweni ezinjalo, inkampani yethule izinsiza zokuhlukanisa ukungcola kwezidakamizwa kanye nezinsizakalo zokuhlanza.Ngokuthembela ku-nuclear magnetic resonance, i-mass spectrometry nezinye izinto zokusebenza nobuchwepheshe, inkampani ingakwazi ukubona ngokushesha ukwakheka kwezinhlanganisela ezihlukanisiwe, ukuze ihlangabezane nezidingo zamakhasimende.

I-SPF Animal Experiment
Indawo yokwakhiwa kwendawo yokuhlolwa kwezilwane ingamamitha-skwele ayi-1500, okuhlanganisa namamitha-skwele angama-400 wendawo yokuhlola yezinga le-SPF kanye namamitha-skwele ayi-100 welebhu yeseli yezinga le-P2.Iholwa ososayensi base-China Pharmaceutical University, yakha ithimba lezobuchwepheshe elibalulekile elinenani labantu ababuyayo.Nikeza amamodeli ezilwane ekhwalithi ephezulu, idizayini yokuhlola, amaphrojekthi aphelele kanye nezinye izinsizakalo zocwaningo lwesayensi ye-biomedical, ukufundisa nokuthuthukiswa kwezimboni.

Ububanzi Bebhizinisi

1. Ukuphakelwa kwezilwane ezincane

2. Ukumodela izifo zezilwane

3. Ukunikezwa kwephrojekthi yasekolishi

4. Ukuhlolwa kwe-Pharmacodynamic ku-vivo

5. Ukuhlolwa kwe-Pharmacokinetic

6. Isevisi yokuhlola iseli yesimila

Amandla Ethu

1. Gxila ekuhloleni kwangempela

2. Qinisekisa ngokuqinile inqubo

3. Sayina ngokuqinile isivumelwano sobumfihlo

4. Ilabhorethri Yakho ngaphandle kwezixhumanisi eziphakathi nendawo

5. Ithimba lochwepheshe bezobuchwepheshe liqinisekisa ikhwalithi yokuhlola

Indawo yokuhlola ye-SPF, ukuphakelwa komuntu okwabelwe ngokukhethekile, inqubekelaphambili yokuhlola yokulandelela ngesikhathi sangempela


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