Products

Ophiopogon Saponin D Name

English Name: (1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)]-6-deoxy-β-D-galactopyranoside

Bioactivity of Ophiopogon Japonicus Saponin D

Description: Ophiopogon D is a rare natural C29 steroidal glycoside isolated from the tuber of Ophiopogon japonicus. Ophiopogonin D is a CYP2J3 inducer that increases CYP2J2 / eets and PPAR in human umbilical vein endothelial cells (HUVECs) α The expression of Ang II significantly inhibited Ang II induced NF- κ B nuclear translocation, I κ B α Down regulation, intracellular Ca2 + overload and activation of proinflammatory cytokines. Ophiopogonin D has been used to treat inflammation and cardiovascular diseases for thousands of years.

Relevant Categories

Signaling pathway > > transmembrane transport > > calcium channel

Research field > > cardiovascular disease

Signaling pathway > > cell cycle / DNA damage > > PPAR

Research field > > inflammation / immunity

Target

PPARα

NF-κB

Ca2+

Reference Documents: [1]. Wang L , et al. Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogonjaponicus. Phytochemistry. 2017 Apr;136:125-132.

[2]. Huang X, et al. Ophiopogonin D and EETs ameliorate Ang II-induced inflammatory responses via activating PPARα in HUVECs. Biochem Biophys Res Commun. 2017 Aug 19;490(2):123-133.

English Alias of Ophiopogon saponin D

(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)]-6-deoxy-β-D-galactopyranoside β-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[β-D-xylopyranosyl-(1->3)]-6-deoxy-

(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-hydroxy-2-(((4R,5′R,6R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-4-hydroxy-5′,6a,8a,9-tetramethyl-1,3,3′,4,4′,5,5′,6,6a,6b,6′,7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2′-pyran]-6-yl)oxy)-6-methyl-4-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol

Ophiopogonin D

Deacetylophiopogonin C