factory customized Cirsiumaldehyde - Methylophiopogonanone A; Opogonanone A – Yongjian
factory customized Cirsiumaldehyde - Methylophiopogonanone A; Opogonanone A – Yongjian Detail:
Application of Methylophiopogonanone A
Methylophiopogonanone A is a flavonoid extracted from Ophiopogon japonicas, which has antioxidant and anti-inflammatory effects.
Name Of Methylophiopogonanone A
English Name:
(3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one
Chinese Alias:
Ophiopogon methyl flavanone a | methyl Ophiopogon dihydrohomoisoflavone a | methyl Ophiopogon flavanone a
Biological Activity Of Methylophiopogonanone A
Description: methylophiopogonanone A is a flavonoid extracted from Ophiopogon japonicas, which has
antioxidant and anti-inflammatory effects.
Related Categories: signal pathway > > apoptosis > > apoptosis
research field > > inflammation / immunity
In Vitro Study: methyl aspartate a (mo-a; 10 μ Mo (L / L) significantly decreased apoptosis and Caspase-3 expression, increased Bcl-2 / Bax ratio and restored no production. Methylaspartate a (mo-a) pretreatment
significantly enhanced the activation of PI3K / Akt / eNOS pathway in H9c2 cells under H / R, while the protective effect of mo-a was cancelled in the presence of PI3K inhibitor wortmannin (100 nmol / L) [1].
In Vivo Study: protective effect of methylaspartate a (mo-a; 10mg / kg / D, PO) on cardiac function after myocardial I / R injury [1].
References: [1] He F, et al. Methylophiopogonanone A suppresses ischemia/reperfusion-induced myocardial apoptosis in mice via activating PI3K/Akt/eNOS signaling pathway. Acta Pharmacol Sin. 2016 Jun; 37(6):763-71.
Physicochemical properties Of Methylophiopogonanone A
Density: 1.4 ± 0.1 g / cm3
Boiling Point: 580.1 ± 50.0 ° C at 760 mmHg
Molecular Formula: c19h18o6
Molecular Weight: 342.343
Flash Point: 212.9 ± 23.6 ° C
Exact Mass: 342.110352
PSA:85.22000
LogP:5.16
Steam Pressure: 0.0 ± 1.7 mmHg at 25 ° C
Refractive Index: 1.654
English Alias Of Methylophiopogonanone A
(1,3-Benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydro-4H-chromen-4-one
4H-1-Benzopyran-4-one, 3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-
N1002
Methylophiopogonanone A
Yongjian Service
Customized Service Of Chemical Reference Materials Of Traditional Chinese Medicine
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd. is mainly engaged in the basic research of active substances of traditional Chinese medicine for more than ten years. So far, the company has conducted in-depth research on more than 100 kinds of commonly used traditional Chinese medicine, and extracted thousands of chemical components.
The company has top R & D personnel and perfect testing and analysis equipment in the industry, and has served hundreds of scientific research institutions. It can quickly and efficiently meet the needs of customers
Drug Impurity Separation, Preparation and Structure Confirmation Service
Impurities in drugs are closely related to the quality, safety and stability of drugs. The preparation and structure confirmation of impurities in drugs can help us understand the ways of impurities and provide a basis for the improvement of production process. Therefore, the preparation and separation of impurities is of great significance to drug research and development.
However, the content of impurities in the drug is low, the source is wide, and the structure is mostly similar to the principal component. What technology can be used to separate and purify all impurities in the drug one by one and quickly? What techniques and methods are used to confirm the structure of these impurities? This is the difficulty and challenge faced by many pharmaceutical units, especially the pharmaceutical enterprises of plant medicine and Chinese patent medicine.
Based on such needs, the company has launched drug impurity separation and purification services. Relying on nuclear magnetic resonance, mass spectrometry and other equipment and technologies, the company can quickly identify the structure of the separated compounds, so as to meet the needs of customers.
SPF Animal Experiment
The construction area of the animal experimental area is 1500 square meters, including 400 square meters of SPF level experimental area and 100 square meters of P2 level cell laboratory. Led by scientists of China Pharmaceutical University, it forms a core technical team with a number of returnees. Provide high-quality animal models, experimental design, overall projects and other services for biomedical scientific research, teaching and industrial development.
Scope Of Business
1. Small animal feeding
2. Animal disease modeling
3. College project outsourcing
4. Pharmacodynamic evaluation in vivo
5. Pharmacokinetic evaluation
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Our Strengths
1. Focus on real experiments
2. Strictly standardize the process
3. Strictly sign confidentiality agreement
4. Own laboratory without intermediate links
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SPF experimental environment, specially assigned person feeding, real-time tracking experimental progress
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We stick to our enterprise spirit of "Quality, Performance, Innovation and Integrity". We purpose to create a lot more price for our prospects with our rich resources, innovative machinery, experienced workers and great products and services for factory customized Cirsiumaldehyde - Methylophiopogonanone A; Opogonanone A – Yongjian , The product will supply to all over the world, such as: Somalia, Portugal, Provence, We pay high attention to customer service, and cherish every customer. We've maintained a strong reputation in the industry for many years. We are honest and work on building a long-term relationship with our customers.
By Jamie from Thailand - 2018.12.05 13:53
It is not easy to find such a professional and responsible provider in today's time. Hope that we can maintain long-term cooperation.
By Sara from Portugal - 2017.11.12 12:31
