Neoisoliquiritin, Neoisoliquiritigenin
ʻO ka hoʻohana ʻana o Neoisoliquiritin
ʻO Neoisoliquiritin, i hoʻokaʻawale ʻia mai ka spatholobus suberectus, ua hui pū ʻia me GRP78 no ka hoʻoponopono ʻana i ke ala β-Catenin e kāohi ai i ka hoʻonui ʻana a hoʻoulu i ka apoptosis i nā maʻi kanesa o ka umauma.
ʻO ka inoa o Neoisoliquiritin
ʻO ka inoa Pelekane: Neoisoliquiritin
Bioactivity o Neoisoliquiritin
ʻO ka wehewehe: ua hoʻokaʻawale ʻia ʻo Neoisoliquiritin mai spatholobus suberectus.Hoʻopili pololei ʻia ʻo Neoisoliquiritin me GRP78 no ka hoʻoponopono ʻana i ke ala β-Catenin e kāohi ai i ka hoʻonui ʻana a hoʻoulu i ka apoptosis i loko o nā pūnaʻi maʻi maʻi umauma.
Nā ʻāpana pili: ke ala hōʻailona > > apoptosis > > apoptosis
Kahua noiʻi > > maʻi 'aʻai
kuhikuhi: [1].TangH,etal.ʻO ka Neoisoliquiritigenin ke kāohi i ka holomua ʻana o ka maʻi ma o ka hoʻopaʻa ʻana i ka hōʻailona GRP78-β-catenin i ka maʻi maʻi umauma.ʻO Curr Cancer Drug Targets.2018;18(4):390-399.
ʻO nā waiwai kino o ka Neoisoliquiritin
Mānoanoa: 1.528
Puni paila: 743.5 ± 60.0 ° C ma 760 mmHg
Ka helu hehee: 230-232 ℃
Ke Kumu Molekala: c21h22o9
Kaila Uila: 263.3 ± 26.4 ° C
Nuipa pololei: 418.126373
LogP:0.76
Pumi mahu: 0.0 ± 2.6 mmHg ma 25 ° C
Hōʻike Hōʻikeʻike: 1.707
ʻO ka inoa Pelekane o Neoisoliquiritin
2Y348H1V4W
2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-[4-(β-D-glucopyranosyloxy)phenyl]-, (2E)-
ʻO Isoliquiritin
MFCD00272145
2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-(4-(β-D-glucopyranosyloxy)phenyl)-, (2E)-
4-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl]phenyl β-D-glucopyranoside
ʻO Jiangsu Yongjian Pharmaceutical Technology Co., Ltd
ʻO Jiangsu Yongjian Pharmaceutical Technology Co., Ltd., i hoʻokumu ʻia ma Malaki 2012, he ʻoihana ʻenehana kiʻekiʻe e hoʻohui ana i ka R&D, ka hana a me ke kūʻai aku.Hoʻohana nui ʻia ia i ka hana ʻana, hana maʻamau a me ka hoʻomohala ʻana i ke kaʻina hana o nā mea ikaika o nā huahana kūlohelohe, nā mea kuhikuhi lāʻau lapaʻau Kina kuʻuna a me nā haumia lāʻau.Aia ka hui ma China Pharmaceutical City, Taizhou City, Jiangsu Province, me kahi kumu hana 5000 square meter a me kahi kumu 2000 square meter R & D.Hoʻohana nui ia i nā keʻena noiʻi ʻepekema nui, nā kulanui a me nā ʻoihana hana ʻāpana decoction a puni ka ʻāina.
I kēia manawa, ua hoʻomohala mākou ma mua o 1500 mau ʻano o nā reagents kūlohelohe, a hoʻohālikelike ʻia a hoʻohālikelike ʻia ma mua o 300 mau ʻano mea kuhikuhi, hiki ke hoʻokō piha i nā pono nānā i kēlā me kēia lā o nā keʻena noiʻi ʻepekema nui, nā hale hana kulanui a me nā ʻāpana decoction.
Ma muli o ke kumu o ka manaʻoʻiʻo maikaʻi, manaʻolana ka hui e hui pū me kā mākou mea kūʻai.ʻO kā mākou pahuhopu ka lawelawe ʻana i ka hana hou o ka lāʻau lapaʻau Kina.
ʻO ka pāʻoihana maikaʻi o ka ʻoihana:
1. R & D, hana a kūʻai aku i nā mea hoʻohālikelike kemika o ka lāʻau lapaʻau Kina;
2. Hoʻopilikino ʻia ka lāʻau lapaʻau Kina kuʻuna monomer e like me nā ʻano mea kūʻai aku
3. E noiʻi e pili ana i ke kūlana maikaʻi a me ka hoʻomohala ʻana o ka lāʻau lapaʻau Kina (mea kanu).
4. Hoʻohui ʻenehana, hoʻololi a me ka noiʻi a me ka hoʻomohala lāʻau hou.
