OEM Customized Comuside - Dimethylfraxetin ;6,7,8-Trimethoxycoumarin – Yongjian
OEM Customized Comuside - Dimethylfraxetin ;6,7,8-Trimethoxycoumarin – Yongjian Detail:
Product Specification
Common Name: ash tree element
CAS No.: 6035-49-0
Density: 1.2 ± 0.1 g / cm3
Molecular Formula: C12H12O5
MSDS: N / A
English Name: dimethylfraxetin
Molecular Weight: 236.221
Boiling Point: 408.0 ± 45.0 ° C at 760 mmHg
Melting Point: 104-105 º C
Flash Point: 184.3 ± 28.8 ° C
Biological activity of dimethylfraxetin
Description: dimethylfraxetin is a carbonic anhydrase inhibitor with a Ki value of 0.0097 μ M。
Related Categories:
signal pathway > > metabolic enzyme / protease > > carbonic anhydrase
Research field > > cancer
Natural Products > > benzoic acids
Target: ki: 0.0097 μ M (Carbonic anhydrase)[1]
In vitro study: in CA I, one prominent compound is dimethylfluoxetine (compound 17), a nanomolar CA I inhibitor. This trimethoxycoumarin is the most effective of any NP coumarin among the six CA isozymes in this study [1].
Kinase: before determination, the inhibitor (including dimethylerythromycin) and the enzyme solution were pre incubated at room temperature for 6 hours to allow the formation of enzyme inhibitor complex [1]
References: [1] Davis RA, et al. Natural product coumarins that inhibit human carbonic anhydrases. Bioorg Med Chem. 2013 Mar 15; 21(6):1539-43.
Dimethylfraxetin
Density: 1.2 ± 0.1 g / cm3
Boiling Point: 408.0 ± 45.0 ° C at 760 mmHg
Melting Point: 104-105 º C
Molecular Formula: c12h12o5
Molecular Weight: 236.221
Flash Point: 184.3 ± 28.8 ° C
Accurate Mass: 236.068466
PSA：57.90000
LogP：1.75
Steam Pressure: 0.0 ± 1.0 mmHg at 25 ° C
Refractive index: 1.545
Dimethylfraxetin Safety Information
Risk statement (Europe): 22
Safety statement (Europe): 22-45
Customs Code: 293220990
Dimethylfraxetin Upstream And Downstream Products
DDimethylfraxetin Upstream Products
CAS 186581-53-3 Diazomethane
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CAS No. 77-78-1 Dimethyl sulfate
DDimethylfraxetin Downstream Products
CAS No.72023-44-0 2,3,4,5-tetrame…
Dimethylfraxetin Customs
Customs Code: 293220990
Chinese overview: 293220990 Other lactones VAT rate: 17.0% Tax rebate rate: 13.0% Regulatory conditions: none MFN tariff: 6.5% General tariff: 20.0%
Declaration elements: product name, composition, content and purpose
Summary：2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
English Alias Of Dimethylfraxetin
6,7,8-trimethoxychromen-2-one
6,7,8-Trimethoxy-2H-chromen-2-one
2H-1-Benzopyran-2-one, 6,7,8-trimethoxy-
Product detail pictures:
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