page_head_bg

Products

Short Lead Time for Cas No.6426-43-3 Taraxasteryl acetate - Cycloastragenol CAS No. 78574-94-4 – Yongjian

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

We know that we only thrive if we can easily guarantee our combined cost competiveness and high-quality advantageous at the same time for Cas No.68124-04-9 Chonglou saponin Ⅶ , Cas No.23513-15-7 10-Gingerol , Cas No.17650-84-9 , With a wide range, top quality, realistic costs and good company, we are going to be your most effective company partner. We welcome new and aged clients from all walks of daily life to call us for long term small business interactions and acquiring mutual achievements!
Short Lead Time for Cas No.6426-43-3 Taraxasteryl acetate - Cycloastragenol CAS No. 78574-94-4 – Yongjian Detail:

Product Specification

[name]: cycloastragalus alcohol

[alias]: triterpenoid cyclic flavonol

[English name]: cycloastragenol

[molecular formula]: C30H50O5

[molecular weight]: 490.71

[CAS No.]: 78574-94-4

[detection method]: HPLC ≥ 98%

[Specification]: 20mg 50mg 100mg 500mg 1g (can be packaged according to customer requirements)

[properties]: this product is colorless acicular crystal

[function and use]: This product is used for content determination, identification, pharmacological experiment, activity screening and other scientific research experiments. Such as cell administration, intragastric test, internal quality inspection of pharmaceutical factory, etc.Source: Astragalus membranaceus (Fisch.) Bge. Dried root extract

Storage Method

2-8 ° C, sealed from light and stored at low temperature.

Note

This product should be stored at low temperature. If it is exposed to air for a long time, the content will be reduced.

Chromatographic conditions} chromatographic column: Zorbax rx-c18 (4.6mm) × 150mm),5 μ m; Mobile phase: acetonitrile water (30:70); Flow rate: 1.0ml/min, column temperature: 35 ℃, ELSD parameters: drift tube temperature: 105 ℃, nitrogen flow rate: 2.70ml/min.

Physicochemical properties: density 1.20

Bioactivity of cycloastragenol

Cycloastragalol is a triterpene saponin compound, which is Astragalus membranaceus (Fisch.) The hydrolysate of the active ingredient in Bunge). Astramembrangenin has oral safety and has a wide range of pharmacological effects, including telomerase activation, telomere prolongation, anti-inflammatory and antioxidant properties. Astramembrangenin has anti-aging properties. CAG stimulates telomerase activity in human newborn keratinocytes and rat nerve cells and induces CREB activation. Astramembrangenin may have a new therapeutic effect in depression

Relevant Categories:
Signaling pathway > > apoptosis > > apoptosis
Research field > > inflammation / immunity
Research field > > neurological diseases

In Vitro Study:
Compared with the carrier control in HEK culture, star membrane protein (0-10 μ M; 3-6 days) increased cell growth [1]. Astramembrangenin(0.3 μ M; 5-90 minutes) induced CREB phosphorylation in primary cortical neurons, and the expression of total CREB in both cell types was not affected by CAG [1]. Star membrane protein (3) μ M; 6-48 hours) can promote in vivo signal transduction in neurons, increase TERT mRNA expression, and show increased bcl 2 mRNA expression [1]. Cell viability assay [1] cell line: HEK cell concentration: 1 μ M,3 μ M,10 μ M culture time: 3-6 days results: cell growth doubled at 6 days. Western blot analysis [1] cell line: neuron cell concentration: 0.3 μ M culture time: 5 minutes, 15 minutes, 30 minutes, 90 minutes. Results: CAG induced CREB activation in neurons. RT-PCR [1] cell line: neuron cell concentration: 3 μ M culture time: 6-48 hours results: the expression of TERT and Bcl 2 mRNA increased.

Reference:
[1]. Ip FC, et al. Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management. Neurosignals. 2014;22(1):52-63.
[2]. Yu Y, et al. Cycloastragenol: An exciting novel candidate for age-associated diseases. Exp Ther Med. 2018 Sep;16(3):2175-2182.
[3]. Sun C, et al. Cycloastragenol mediates activation and proliferation suppression in concanavalin A-induced mouse lymphocyte pan-activation model. Immunopharmacol Immunotoxicol. 2017 Jun;39(3):131-139.

Physicochemical Properties Of Cycloastragenol

Density: 1.2 ± 0.1 g / cm3

Boiling point: 617.2 ± 55.0 ° C at 760 mmHg

Melting point: 241.0 to 245.0 ° C

Molecular formula: c30h50o5

Molecular weight: 490.715

Flash point: 327.1 ± 31.5 ° C

Exact mass: 490.365814

PSA:  90.15000

LogP: 3.82

Steam pressure: 0.0 ± 4.0 mmHg at 25 ° C

Refractive index: 1.582

Cycloastragenol Safety Information

Transport code of dangerous goods: nonh for all modes of transport

RTECS number; GX8265000

Customs Code: 2942000000

Cycloastragalol Customs

Customs Code: 2942000000

Cycloastragalol Literature

Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management.

Neurosignals 22(1) , 52-63, (2014)
Cycloastragenol (CAG) is an aglycone of astragaloside IV. It was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. The present study de…
A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis.

PLoS ONE 8(3) , e58423, (2013)
The emergence of diseases associated with telomere dysfunction, including AIDS, aplastic anemia and pulmonary fibrosis, has bolstered interest in telomerase activators. We report identification of a n…
Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes.

J. Immunol. 181(10) , 7400-6, (2008)
Telomerase reverse transcribes telomere DNA onto the ends of linear chromosomes and retards cellular aging. In contrast to most normal somatic cells, which show little or no telomerase activity, immun…

English Alias of Cycloastragalol

9,19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24S)-

Astramembrangenin

(3β,6α,9β,16β,20R,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol

19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24R)-

(3β,6α,9β,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol

Cyclosieversigenin

Cyclogalegigenin


Product detail pictures:

Short Lead Time for Cas No.6426-43-3 Taraxasteryl acetate - Cycloastragenol CAS No. 78574-94-4 –  Yongjian detail pictures

Short Lead Time for Cas No.6426-43-3 Taraxasteryl acetate - Cycloastragenol CAS No. 78574-94-4 –  Yongjian detail pictures

Short Lead Time for Cas No.6426-43-3 Taraxasteryl acetate - Cycloastragenol CAS No. 78574-94-4 –  Yongjian detail pictures


Related Product Guide:

Always customer-oriented, and it's our ultimate goal to get not only by far the most reputable, trustable and honest supplier, but also the partner for our customers for Short Lead Time for Cas No.6426-43-3 Taraxasteryl acetate - Cycloastragenol CAS No. 78574-94-4 – Yongjian , The product will supply to all over the world, such as: Hanover, Pakistan, Netherlands, We have more than 200 staff including experienced managers, creative designers, sophisticated engineers and skilled workers. Through hard work of all employees for the past 20 years own company grew stronger and stronger. We always apply the "client first" principle. We also always fulfill all contracts to the point and therefore enjoy excellent reputation and trust among our customers. You are very welcome to personally visit our company.We hope to start a business partnership on the basis of mutual benefit and successful development . For more information please do no hesitate to contact us..
  • We are a small company that has just started, but we get the company leader's attention and gave us a lot of help. Hope we can make progress together!
    5 Stars By Klemen Hrovat from Lebanon - 2018.11.22 12:28
    The factory workers have rich industry knowledge and operational experience, we learned a lot in working with them,we are extremely grateful that we can encount a good company has excellent wokers.
    5 Stars By Pearl Permewan from Cairo - 2017.09.28 18:29
    Write your message here and send it to us