page_head_bg

Products

Special Design for Cas No.86849-77-6 - Jujuboside A CAS No. 55466-04-1 – Yongjian

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

Having a sound small business credit score, outstanding after-sales services and modern manufacturing facilities, we've got earned an fantastic reputation among our buyers across the globe for Cas No.6807-83-6 , Cas No.17650-84-9 , Cas No.7389-38-0 Cirsiumaldehyde , Standing still today and looking into the future, we sincerely welcome customers all over the world to cooperate with us.
Special Design for Cas No.86849-77-6 - Jujuboside A CAS No. 55466-04-1 – Yongjian Detail:

Essential Information

Chinese alias: jujube kernel saponin A, jujube kernel saponin A; Jujube kernel saponin A (standard)

English name: Jujuboside A

Plant source: it comes from the seeds of wild jujube, also known as jujube kernel and wild jujube core

Molecular formula: C58H94O26

Molecular weight: 1207.35

CAS No. 55466-04-1

Bioactivity of Jujuboside A

Target: GABA receptor, mTOR, PI3K, Akt [1] [2]

In vitro study: low dose 41 μ Jujuboside A of M (about 0.05 g / L) induced GABA (a) receptors during 24 and 72 h treatment α 1, α 5, β 2 subunit mRNA increased significantly. High dose 82 μ M (about 0.1 g / L) Jujuboside A significantly increased GABA (a) receptors at 24 h α 1, α 5 subunit mRNA levels and decreased β 2 subunit mRNA level and decreased GABA (a) receptor subunit α 1, β 2 mRNA expression was treated at 72 h [1]. Jujuboside A pretreatment can reverse the decrease of cell viability and better induce ISO induced H9c2 cell injury. Jujuboside A can accelerate the phosphorylation of PI3K, Akt and mTOR. Jujuboside A can significantly reduce the proportion of microtubule associated protein LC3-II / I in H9c2 cells [2]

In vivo study: during the day (9:00-15:00), jujubosides significantly increased total sleep and rapid eye movement (REM) sleep, but had no significant effect on non REM (NREM) sleep. At night (21:00-3:00), jujubosides significantly increased total sleep and NREM sleep, especially mild sleep, but had no significant effect on REM sleep and slow wave sleep (SWS) [3]. Intraventricular treatment with jjuboside a was significantly alleviated by a through Y-maze, active avoidance and Morris water maze measurements β 1-42 induced learning and memory impairment in mice. Intracerebroventricular injection of Jujuboside A decreased hippocampal a β 1-42 levels significantly inhibited the activities of acetylcholinesterase (AChE) and no, and decreased the increased content of malondialdehyde (MDA) in hippocampus and cerebral cortex of mice injected into lateral ventricle β 1-42[4]。

Cell experiment: after 7 days of culture in vitro, the cells were continuously exposed for 24 hours or 72 hours, and were not exposed to the medium containing Jujuboside A or diazepam or both. Vector was added to the control group; Diazepam group added 10 μ M diazepam; Jujuboside A82 μ M (about 0.1g / L) and 41 μ M (about 0.05 g / L) was added to jua-h (high dose Jujuboside A) and jua-l (low dose Jujuboside A) groups, respectively. Total RNA was isolated from cells for further analysis [1].

Animal experiment: mice: a was injected through ICV β 1-42 induced cognitive impairment in mice. Then, mice were injected with Jujuboside A (0.02 and 0.2 mg / kg) intraventricular (ICV) for 5 days. Y maze, active avoidance and Morris water maze tests were performed on mice [1].

English Alias of Jujuboside A

α-L-arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-

(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α -L-arabinopyranoside

jujuboside C

α-L-Arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]- β-D-glucopyranosyl-(1->3)]-

JujubosideA

(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α-L-arabinopyranoside


Product detail pictures:

Special Design for Cas No.86849-77-6 - Jujuboside A CAS No. 55466-04-1 –  Yongjian detail pictures

Special Design for Cas No.86849-77-6 - Jujuboside A CAS No. 55466-04-1 –  Yongjian detail pictures


Related Product Guide:

We have been ready to share our knowledge of advertising and marketing worldwide and recommend you suitable products and solutions at most competitive price ranges. So Profi Tools supply you best benefit of money and we're ready to create with each other with Special Design for Cas No.86849-77-6 - Jujuboside A CAS No. 55466-04-1 – Yongjian , The product will supply to all over the world, such as: Iraq, Angola, Iran, Our company promises: reasonable prices, short production time and satisfactory after-sales service, we also welcome you to visit our factory at any time you want. Wish we have a pleasant and long terms business together!!!
  • Product variety is complete, good quality and inexpensive, the delivery is fast and transport is security, very good, we are happy to cooperate with a reputable company!
    5 Stars By Julie from Manchester - 2018.09.12 17:18
    Customer service staff and sales man are very patience and they all good at English, product's arrival is also very timely, a good supplier.
    5 Stars By Helen from Kazakhstan - 2018.10.09 19:07
    Write your message here and send it to us