Products

Application of Esculetin

[purpose I]

Used as pharmaceutical intermediate

Name Of Esculetin

Chinese Name: 6,7-dihydroxycoumarin

English Name: esculetin

Chinesea Alias: Aesculetin, Aesculetin, Aesculetin B, Aesculetin a; Aescin; Horse millet bark glycoside; Aesculin, chestnut bark, Aesculetin B, 6,7-dihydroxylavender

Bioactivity Of Esculetin

Description: esculetin is an active ingredient mainly extracted from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF) – induced phenotypic transformation of airway smooth muscle cells (ASMCs) by inhibiting PI3K / Akt pathway. Esculetin has antioxidant, anti-inflammatory and anti-tumor effects.

Related categories: research field > > cancer

Signal pathway > > PI3K / Akt / mTOR signal pathway > > PI3K

Signal pathway > > PI3K / Akt / mTOR signal pathway > > Akt

Target: PI3K Akt

References: [1] Xie C, et al. Esculetin regulates the phenotype switching of airway smooth muscle cells. Phytother Res. 2019 Aug 21.

Physicochemical Properties of Esculetin

Density: 1.6 ± 0.1 g / cm³

Boiling Point: 469.7 ± 45.0 ° C at 760 mmHg

Melting Point: 271-273 ° C (lit.)

Molecular Formula: c9h6o4

Molecular Weight: 178.141

Flash Point: flash point

Accurate Mass: 178.026611

PSA:70.67000

LogP:0.98

Appearance: yellow crystalline powder

Steam Pressure: 0.0 ± 1.2 mmHg at 25 ° C

Refractive Index: 1.689

Storage Conditions: 2-8 ° C

Stability

1 It exists in flue-cured tobacco and Burley tobacco.

2. It is used in the color filter to absorb ultraviolet light.

Water solubility: slightly soluble

Molecular Structure

1. Molar refractive index: 43.52

2. Molar volume (cm3 / mol): 113.9

3. Isotonic specific volume (90.2k): 336.0

4. Surface tension (dyne / cm): 75.6

5. Polarizability (10-24cm3): 17.25

Toxicological Data Of Esculetin

Toxicological data:

Acute toxicity: not available.

Aesculetin ecological data:

Ecological data:

Other harmful effects: the substance may be harmful to the environment, so special attention should be paid to the water body.

 Esculetin Safety Information

Hazard statement: h315-h319-h335

Warning Statement: p261-p305 + P351 + P338

Personal Protective Equipment: dust mask type N95 (US); Eyeshields; Gloves

Hazard Code (Europe): Xi: iritant

Risk Statement (Europe): R36 / 37 / 38

Safety Statement (Europe): s26-s36-s37 / 39

Transport Code Of Dangerous Goods: nonh for all modes of transport

Wgk Germany: 3

RTECS No.: gn6382500

Packing Grade: I; II; III

Customs Code: 293220990

Preparation Of Esculetin

1.It is obtained by acylation and cyclization of benzoquinone.

2.Obtained by hydrolysis of aescin or cichorin. 

Esculetin Customs

Customs Code: 293220990

Chinese overview: 293220990 Other lactones VAT rate: 17.0% Tax rebate rate: 13.0% Regulatory conditions: none MFN tariff: 6.5% General tariff: 20.0%]

Declaration Elements: product name, composition, content and purpose

Summary:2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Esculetin Literature

Coumarins as new matrices for matrix-assisted laser-desorption/ionization Fourier transform ion cyclotron resonance mass spectrometric analysis of hydrophobic compounds.

Anal. Chim. Acta 882 , 49-57, (2015)

Hydrophobic compounds with hydroxyl, aldehyde or ketone groups are generally difficult to detect using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), because these compounds…

The influence of chronic eicosanoid biosynthesis inhibition on life history of the greater waxmoth, Galleria mellonella and its ectoparasitoid, Bracon hebetor.

J. Insect Physiol. 57(4) , 501-7, (2011)

Eicosanoids are oxygenated metabolites of three C20 polyunsaturated fatty acids, mainly arachidonic acid (AA; 20:4n-6), but also 20:3n-6 and 20:5n-3. Aside from their importance in biomedicine, eicosa…

Zinc oxide nanoparticles induce lipoxygenase-mediated apoptosis and necrosis in human neuroblastoma SH-SY5Y cells.

Neurochem. Int. 90 , 204-14, (2015)

Zinc oxide nanoparticles (ZnO NPs) are known to induce oxidative stress and modulate an inflammatory process in various cell types. Although the cytotoxic effects of ZnO NPs in various cell types have…

 English Alias Of Esculetin

Aesculetin

Cryptotanshinone

ESCULETOL

CICHERINGENIN

Cichorigenin

Asculetine

Esculatin

6,7-Dihydroxycoumarin

Esculetin

2H-1-Benzopyran-2-one, 6,7-dihydroxy-

6,7-dihydroxy-2H-1-benzopyran-2-one

Coumarin, 6,7-dihydroxy-

MFCD00006874

EINECS 206-161-5