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Description: monoammonium glycyrrhizinate hydrate has pharmacological activities such as anti-inflammatory, anti allergic, anti gastric ulcer and anti hepatitis.

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Research field > > inflammation / immunity

In Vivo Study: the increase of lung w / D weight ratio was significantly reduced by administration of high and medium doses of mag (10 and 30 mg / kg). Pretreatment with mag (10 and 30 mg / kg) effectively reduced TNF- α And IL-1 β Generation of. Mag (10,30 mg / kg) significantly reduced NF compared with LPS- κ Bp65 protein expression. In contrast, LPS significantly reduced I compared with the control group κ B- α Protein expression, while mag (10 and 30 mg / kg) significantly increased I κ B- α Expression [1]. Compared with RIF and INH groups, low-dose and high-dose MAG treatment significantly reduced ast, alt, TBIL and TBA levels at 14 and 21 days, indicating the protective effect of MAG on RIF - and INH -. Induce liver injury. MAG treatment group increased liver GSH level at 7, 14 and 21 days, and significantly decreased MDA level at 14 and 21 days in RIF and INH treated rats, indicating the protective effect of MAG in RIF - and. INH induced liver injury [2].

Animal Experiments: mice [1] in this study, BALB / c mice (male, 6-8 weeks old, 20-25g) were used. Mice were randomly divided into 5 groups: control group, LPS group and LPS + monoammonium glycyrrhizinate (Mag: 3,10 and 30mg / kg). Each group contained 8 mice. Mice were anesthetized with intraperitoneal injection of pentobarbital sodium (50 mg / kg). Mice were injected intraperitoneally with mag (3, 10 and 30 mg / kg) before inducing acute lung injury. After 1 hour, LPS (5 mg / kg) was injected intratracheal to induce acute lung injury. Normal mice were given PBS [1]. Rats [2] used male Wistar rats (180-220g). The rats were randomly divided into 4 groups: control group, RIF and INH group, MAG low-dose group and MAG high-dose group, with 15 rats in each group. Rats in RIF and INH groups were given RIF (60mg / kg) and INH (60mg / kg) by gavage once a day; Rats in MAG group were pretreated with MAG at the dose of 45 or 90 mg / kg, and RIF (60 mg / kg) and INH (60 mg / kg) were given 3 hours after MAG administration; The rats in the control group were treated with normal saline. In order to evaluate the dynamic effect of the drug, the rats in each group were killed 7, 14 and 21 days after administration [2].

Reference:1]. Huang X, et al. Anti-Inflammatory Effects of Monoammonium Glycyrrhizinate on Lipopolysaccharide-Induced Acute Lung Injury in Mice through Regulating Nuclear Factor-Kappa B Signaling Pathway. Evid Based Complement Alternat Med. 2015;2015:272474.
[2]. Zhou L, et al. Monoammonium glycyrrhizinate protects rifampicin- and isoniazid-induced hepatotoxicity via regulating the expression of transporter Mrp2, Ntcp, and Oatp1a4 in liver. Pharm Biol. 2016;54(6):931-7.