Kayayyaki

Bayani:Danshensu wani abu ne mai tasiri na Salvia miltiorrhiza, wanda zai iya kunna hanyar siginar Nrf2 da kuma kare tsarin zuciya da jijiyoyin jini.
Rukunin alaƙa: Hanyar sigina > > autophagy > > autophagy
Hanyar sigina > > NF- κ hanyar siginar B > > keap1-nrf2
Filin bincike > > cututtukan zuciya
Samfuran Halitta > > benzoic acid

A cikin Nazarin Vitro:Danshensu (DSS) ya rage yawan matakan enzymes masu alama (creatine kinase da lactate dehydrogenase) na fitowar jijiyoyin jini da girman infarction na zuciya.Wannan na iya inganta mahimmancin farfadowa na aikin zuciya bayan rauni na I / R.Har ila yau, DSS yana da aikin ɓarna na ROS kuma yana haɓaka ayyukan antioxidants masu ƙarfi kamar SOD, cat, MDA, GSH-Px da HO-1 ta hanyar kunna hanyar siginar erythrocyte-2 mai alaƙa da nukiliya ta hanyar Akt da ERK1.2 a cikin bincike na Western blot [2].

A cikin Nazarin Vivo:m magani tare da kashi ɗaya na Danshensu bai canza plasma tHcy a cikin berayen tare da al'ada tHcy ba.Sabanin haka, Danshensu ya rage girman tHcy a cikin beraye tare da haɓakar tHcy.Ingantattun matakan cysteine ​​da glutathione bayan jiyya tare da Danshensu sun nuna cewa tasirinsa na rage thHcy shine ta hanyar haɓaka ayyukan hanyar vulcanization [1].

Gwajin Dabbobi:An narkar da duk sinadarai a cikin gishiri sai dai tolcapone da aka narkar da shi a cikin salin mai dauke da 20% (V / V) peg 200. A lokacin gwajin, an yi azumin berayen dare da rana kuma an ba da izini ga kungiyoyi daban-daban.Bayan ether anesthesia, game da 200 an cire daga orbital sinus μ L jini, sa'an nan da sauri kashe barasa da kuma danna da auduga.An tattara samfuran jini nan da nan a cikin bututun polypropylene mai ɗauke da sodium heparin kuma an sanya su a 5000 g a 5 ° C na mintuna 3.An adana samfuran plasma da aka shirya a -20 ℃ kuma an bincika cikin sa'o'i 48.

Magana:[1] YG Cao, et al.Tasirin amfani da danshensu, wani sashi mai aiki na Salvia miltiorrhiza, akan metabolism na homocysteine ​​​​ta hanyar trans-sulphuration a cikin berayen.Br J Pharmacol.2009 Juni;157 (3): 482-490.

[2].Yu J, et al.Danshensu yana kare keɓaɓɓen zuciya daga raunin ischemia reperfusion ta hanyar kunna siginar Akt/ERK1/2/Nrf2.Int J Clin Exp Med.2015 Satumba 15;8 (9): 14793-804.